Patents by Inventor John A. Lowe

John A. Lowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrugs of secondary amine compounds
    Patent number: 8969337
    Abstract: The present invention relates to compounds of Formula I:
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: March 3, 2015
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Laura Cook Blumberg, John A. Lowe, Orn Almarsson, Juan Alvarez, Tarek A. Zeidan
  • Bicyclic [3.1.0] derivatives as glycine transporter inhibitors
    Patent number: 7473787
    Abstract: The present invention relates to a series of substituted bicyclic[3.1.0]amines of the Formula I: wherein A, B, D, Q, V, W, X, Y, Z, R2, R3, R4, R5, R14, R15, R30. o, p, s,t and q are as defined in the specification, their pharmaceutically acceptable salts, pharmaceutical compositions thereof, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other psychoses in mammals, including humans.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: January 6, 2009
    Assignee: Pfizer Inc
    Inventors: Stanton McHardy, John A. Lowe
  • Method and system for providing service request notifications related to a communications network
    Patent number: 7336639
    Abstract: A trunk-group request tool automates the process of manually receiving and analyzing trunk-group circuits pertaining to switch circuits located within a switch facility of a communications network. An embodiment of the computer-implemented method includes receiving a switch or vendor identifier from a data structure, presenting records of information of one or more trunk groups associated with the identifier(s), receiving one or more trunk-group attributes from one or more entry fields, populating a data structure by aggregating one or more records of information of a data structure of the switch and vendor identifier with one or more trunk-group attributes, providing an input field for receiving additional data to supplement one or more records of information or one or more trunk-group attributes, and presenting a report adhering to a predefined format using the information of the data structure.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: February 26, 2008
    Assignee: Embarq Holdings Company, LLC
    Inventors: Zyad Ahmad Dwekat, Jeffrey M. Fries, Farooq Ijaz Cheema, John A. Lowe
  • 2-amino-6-(2,4,5-substituted-phenyl)-pyridines
    Publication number: 20040077853
    Abstract: The invention provides compounds of formula VI 1
    Type: Application
    Filed: February 18, 2003
    Publication date: April 22, 2004
    Applicant: Pfizer Inc.
    Inventors: John A. Lowe, Robert A. Volkmann
  • Combination treatment for depression and anxiety
    Publication number: 20040006135
    Abstract: The present invention relates to a method of treating depression or anxiety in a mammal, including a human, by administering to the mammal a CNS-penetrant NK-1 receptor antagonist (e.g., a substance P receptor antagonist) in combination with an NK-3 antagonist agent. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier, a CNS-penetrant NK-1 receptor antagonist and an NK-3 antagonist.
    Type: Application
    Filed: March 12, 2003
    Publication date: January 8, 2004
    Applicant: Pfizer Inc.
    Inventors: Susan B. Sobolov-Jaynes, John A. Lowe, Stafford McLean
  • Pharmaceutical combinations comprising a NOS inhibitor and an NMDA receptor antagonist
    Publication number: 20030232739
    Abstract: This invention relates to methods of treating neurodegenerative diseases and inhibiting neurological damage, comprising administering to a patient in need of such treatment an N-NOS inhibitor in combination with an NMDA receptor antagonist.
    Type: Application
    Filed: February 18, 2003
    Publication date: December 18, 2003
    Applicant: Pfizer Inc.
    Inventors: John A. Lowe, Robert A. Volkman
  • Substituted aromatic ethers as inhibitors of glycine transport
    Publication number: 20030208081
    Abstract: This invention relates to a series of substituted aromatic ethers of the formula I 1
    Type: Application
    Filed: April 16, 2003
    Publication date: November 6, 2003
    Applicant: Pfizer Inc.
    Inventor: John A. Lowe
  • 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines
    Publication number: 20030162765
    Abstract: This present invention relates to compounds of the formula 1
    Type: Application
    Filed: February 20, 2003
    Publication date: August 28, 2003
    Applicant: Pfizer Inc.
    Inventors: Robert A. Volkmann, John A. Lowe, Jolanta Nowakowski
  • 2-Amino-6-(2,4,5-substituted-phenyl)-pyridines
    Publication number: 20030087891
    Abstract: The present invention relates to the compounds 6-[4-(N-methyl-3-azetidinoxy)-5-ethyl-2-methoxy-phenyl]-pyridin-2-ylamine, 6-[4-(N,N-dimethylaminomethyl)-5-ethyl-2-methoxy-phenyl]-pyridin-2-ylamine, 6-[4-(N-methylaminomethyl)-5-ethyl-2-methoxy-phenyl]-pyridin-2-ylamine and 6-[4-(3-azetidinoxy)-5-ethyl-2-methoxy-phenyl]-pyridin-2-ylamine, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing such compounds and to the use of such compounds in the treatment and prevention of central nervous system and other disorders.
    Type: Application
    Filed: October 8, 2002
    Publication date: May 8, 2003
    Applicant: Pfizer Inc.
    Inventors: John A. Lowe, Robert A. Volkmann
  • Pharmaceutical combinations for the treatment of neurodegenerative diseases
    Publication number: 20030045449
    Abstract: This invention relates to methods of treating neurodegenerative diseases, comprising administering to a patient in need of such treatment an N-NOS inhibitor in combination with either: (a) NMDA receptor antagonist; (b) a sodium channel antagonist; (c) an acetylcholine esterase inhibitor; (d) a dopamine agonist; (e) a potassium channel opener; (f) an AMPA/kainate receptor antagonist; (g) a calcium channel antagonist; (h) a GABA-A receptor modulator (e.g., a GABA-A receptor agonist); (i) TPA (j) matrix-metalloprotease inhibitor or (k) L-Dopa. The pharmaceutical compounds are also disclosed.
    Type: Application
    Filed: May 1, 2002
    Publication date: March 6, 2003
    Applicant: Pfizer, Inc.
    Inventors: John A. Lowe, Robert A. Volkmann
  • Substituted aromatic ethers as inhibitors of glycine transport
    Publication number: 20030013887
    Abstract: This invention relates to a series of substituted aromatic ethers of the formula I 1
    Type: Application
    Filed: February 28, 2002
    Publication date: January 16, 2003
    Applicant: Pfizer Inc.
    Inventor: John A. Lowe
  • PHARMACEUTICAL USES FOR NOS INHIBITORS
    Publication number: 20020151572
    Abstract: The present invention relates to new pharmaceutical uses for compounds that exhibit activity as nitric oxide synthase (NOS) inhibitors. Specifically, it relates to the use of NOS inhibitors, particularly selective neuronal NOS (N-NOS) inhibitors: (a) alone or in combination with another active agent for the treatment of psoriasis; (b) in combination with an antiinflammatory agent for the treatment of inflammatory disorders; (c) in combination with a narcotic analgesic (e.g., opiates such as morphine or demerol) for the treatment of pain; (d) alone or in combination with other active agents for the enhancement of cognition; and (e) alone or in combination with other active agents for the treatment of sleep disorders such as apnea, narcolepsy and insomnia.
    Type: Application
    Filed: August 11, 1999
    Publication date: October 17, 2002
    Inventor: JOHN A. LOWE
  • 6-Phenylpyridyl-2-amine derivatives useful as NOS inhibitors
    Publication number: 20020103227
    Abstract: The present invention relates to 6-phenyl-pyridin-2-ylamine derivatives of the formula 1
    Type: Application
    Filed: September 27, 2001
    Publication date: August 1, 2002
    Inventor: John A. Lowe
  • Benzophenones and sulfones as inhibitors of glycine uptake
    Publication number: 20020052401
    Abstract: This invention relates to a series of substituted benzophenone and sulfone compounds of the formula I 1
    Type: Application
    Filed: July 2, 2001
    Publication date: May 2, 2002
    Applicant: Pfizer Inc.
    Inventor: John A. Lowe
  • 6-phenylpyridyl-2-amine derivatives useful as NOS inhibitors
    Publication number: 20020032191
    Abstract: The present invention relates to 6-phenyl-pyridin-2-ylamine derivatives of the formula 1
    Type: Application
    Filed: March 8, 2001
    Publication date: March 14, 2002
    Inventor: John A. Lowe
  • 6-phenylpyridyl-2-amine derivatives
    Publication number: 20010034348
    Abstract: The present invention relates to certain 6-phenyi-pyridin-2-ylamine derivatives that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system disorders.
    Type: Application
    Filed: April 4, 2001
    Publication date: October 25, 2001
    Inventors: John A. Lowe, Peter J. Whittle
  • 2-aminopyridines containing fused ring substituents
    Publication number: 20010014689
    Abstract: The present invention relates to 2-aminopyridine derivatives of the formula I: 1
    Type: Application
    Filed: February 8, 2001
    Publication date: August 16, 2001
    Inventor: John A. Lowe
  • 2-AMINO-6-(2-SUBSTITUTED-4-PHENOXY)-SUBSTITUTED-PYRIDINES
    Publication number: 20010007873
    Abstract: This present invention relates to compounds of the formula 1
    Type: Application
    Filed: July 31, 1998
    Publication date: July 12, 2001
    Inventors: ROBERT A. VOLKMANN, JOHN A. LOWE, JOLANTA NOWAKOWSKI