Patents by Inventor John A. Lowe, III

John A. Lowe, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11912702
    Abstract: Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g,. HDAC2).
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: February 27, 2024
    Assignee: Alkermes, Inc.
    Inventors: Nathan Oliver Fuller, John A. Lowe, III
  • Patent number: 11858939
    Abstract: This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.
    Type: Grant
    Filed: December 28, 2020
    Date of Patent: January 2, 2024
    Assignee: Alkermes, Inc.
    Inventors: Martin R. Jefson, John A. Lowe, III, Fabian Dey, Andreas Bergmann, Andreas Schoop, Nathan Oliver Fuller
  • Publication number: 20220340558
    Abstract: Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2).
    Type: Application
    Filed: December 22, 2021
    Publication date: October 27, 2022
    Inventors: Nathan Oliver Fuller, John A. Lowe, III
  • Publication number: 20220340560
    Abstract: Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g,. HDAC2).
    Type: Application
    Filed: December 22, 2021
    Publication date: October 27, 2022
    Inventors: Nathan Oliver Fuller, John A. Lowe, III
  • Publication number: 20220151992
    Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
    Type: Application
    Filed: June 24, 2021
    Publication date: May 19, 2022
    Inventors: John A. Lowe, III, M. Amin Khan
  • Patent number: 11286256
    Abstract: Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g,. HDAC2).
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: March 29, 2022
    Assignee: Alkermes, Inc.
    Inventors: Nathan Oliver Fuller, John A. Lowe, III
  • Patent number: 11225475
    Abstract: Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2).
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: January 18, 2022
    Assignee: Alkermes, Inc.
    Inventors: Nathan Oliver Fuller, John A. Lowe, III
  • Patent number: 11225490
    Abstract: The present invention relates to compounds of Formula I:
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: January 18, 2022
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Laura Cook Blumberg, John A. Lowe, III, Orn Almarsson, Juan C. Alvarez, Tarek A. Zeidan
  • Patent number: 11225479
    Abstract: Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2).
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: January 18, 2022
    Assignee: Alkermes, Inc.
    Inventors: Nathan Oliver Fuller, John A. Lowe, III
  • Publication number: 20210276977
    Abstract: Provided herein are compounds of Formula I and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with histone deacetylases (HDAC).
    Type: Application
    Filed: July 12, 2019
    Publication date: September 9, 2021
    Inventors: Nathan Oliver Fuller, John A. Lowe, III
  • Publication number: 20210277007
    Abstract: This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.
    Type: Application
    Filed: December 28, 2020
    Publication date: September 9, 2021
    Inventors: Martin R. Jefson, John A. Lowe, III, Fabian Dey, Andreas Bergmann, Andreas Schoop, Nathan Oliver Fuller
  • Publication number: 20210276978
    Abstract: Provided herein are compounds of the Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with histone deacetylases (HDAC).
    Type: Application
    Filed: July 12, 2019
    Publication date: September 9, 2021
    Inventors: Nathan Oliver Fuller, John A. Lowe, III
  • Patent number: 11077094
    Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: August 3, 2021
    Assignee: Aptinyx Inc.
    Inventors: John A. Lowe, III, M. Amin Khan
  • Publication number: 20210155632
    Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
    Type: Application
    Filed: July 2, 2020
    Publication date: May 27, 2021
    Inventors: John A. Lowe, III, M. Amin Khan
  • Publication number: 20210147410
    Abstract: Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g. HDAC2).
    Type: Application
    Filed: August 7, 2018
    Publication date: May 20, 2021
    Inventors: Nathan Oliver Fuller, John A. Lowe, III
  • Publication number: 20210122748
    Abstract: Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2).
    Type: Application
    Filed: August 31, 2020
    Publication date: April 29, 2021
    Inventors: Nathan Oliver Fuller, John A. Lowe, III
  • Patent number: 10954250
    Abstract: The present invention relates to compounds of Formula I:
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: March 23, 2021
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Laura Cook Blumberg, John A. Lowe, III, Orn Almarsson, Juan Alvarez, Tarek A. Zeidan
  • Publication number: 20210053964
    Abstract: Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2).
    Type: Application
    Filed: May 21, 2020
    Publication date: February 25, 2021
    Inventors: Nathan Oliver Fuller, John A. Lowe, III
  • Patent number: 10919902
    Abstract: This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: February 16, 2021
    Assignee: Alkermes, Inc.
    Inventors: Martin R. Jefson, John A. Lowe, III, Fabian Dey, Andreas Bergmann, Andreas Schoop, Nathan Oliver Fuller
  • Patent number: 10793567
    Abstract: Provided are compounds of the formula and pharmaceutically acceptable salts and composition thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g. HDAC2).
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: October 6, 2020
    Assignee: Rodin Therapeutics, Inc.
    Inventors: Nathan Oliver Fuller, John A. Lowe, III