Patents by Inventor John A. Lowe, III

John A. Lowe, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinuclidine therapeutic agents
    Patent number: 5162339
    Abstract: A series of cis-3-[(cyclic)methylamino]-2-[(.alpha.-substituted)arylmethyl]quinuclidin es, 3-[(cyclic)methylimino]-2-[(.alpha.-substituted)-arylmethyl]quinuclidines and cis-3-[(cyclic)-methyleneamino]-2-[(.alpha.-substituted)arylmethyl]-quinuc lidines, including their pharmaceutically acceptable salts, are disclosed. These particular compounds are found to be useful as substance P antagonists and therefore, are of value in treating gastrointestinal disorders, central nervous system disorders, inflammatory diseases and pain or migraine. Preferred member compounds include cis-3-[(2-chlorophenyl)methylamino]-2-benzhydryl-quinuclidine, cis-3-[(2-trifluorophenyl)methylamino]2-benzhydrylquinuclidine and cis-[(2-methoxyphenyl)methylamino]-2-benzhydrylquinuclidine. Methods for preparing these compounds from known starting materials are provided.
    Type: Grant
    Filed: July 20, 1990
    Date of Patent: November 10, 1992
    Assignee: Pfizer Inc.
    Inventor: John A. Lowe, III
  • Heterocycylic-substituted quinoline-carboxylic acids
    Patent number: 5037834
    Abstract: 1-Substituted-6-fluoro-7-heterocyclic-1,4-dihydroquino-1-(or dihydronaphthyridin)-4-one carboxylic acids have antibacterial properties. The 7-heterocyclic group is a bicyclic group, one of the rings of which is saturated and the other ring of which is unsaturated.
    Type: Grant
    Filed: August 1, 1989
    Date of Patent: August 6, 1991
    Assignee: Pfizer Inc.
    Inventors: Katherine E. Brighty, John A. Lowe, III, Paul R. McGuirk
  • Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds
    Patent number: 4891375
    Abstract: Arylpiperazinyl-alkylenephenyl-p-heterocyclic compounds, and the pharmaceutically acceptable acid addition salts thereof are neuroleptic agents. They are useful in the treatment of psychotic disorders.
    Type: Grant
    Filed: January 13, 1988
    Date of Patent: January 2, 1990
    Assignee: Pfizer Inc.
    Inventor: John A. Lowe, III
  • Piperazinyl-heterocyclic compounds
    Patent number: 4883795
    Abstract: Arylpiperazinyl-ethyl (or butyl)-heterocyclic compounds and their pharmaceutically acceptable acid addition salts are neuroleptic agents. They are useful in the treatment of psychotic disorders.
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: November 28, 1989
    Assignee: Pfizer Inc.
    Inventors: John A. Lowe, III, Arthur A. Nagel
  • Quinazolinediones and pyridopyrimidinediones
    Patent number: 4880810
    Abstract: 1-Phenylquinazoline-1H,3H-2,4-diones and 1-phenylpyrido-[2,3d]-pyrimidine-1H,3H-2,4-diones, their esters and acid addition salts, and pharmaceutical compositions containing such compounds have antidepressant, anti-inflammatory and analgesic activity.
    Type: Grant
    Filed: January 3, 1989
    Date of Patent: November 14, 1989
    Assignee: Pfizer Inc.
    Inventor: John A. Lowe, III
  • Aryl piperazinyl-(C.sub.2 or C.sub.4) alkylene heterocyclic compounds having neuroleptic activity
    Patent number: 4831031
    Abstract: Arylpiperazinyl-ethyl(or butyl)-heterocyclic compounds and their pharmaceutically acceptable acid addition salts are neuroleptic agents. They are useful in the treatment of psychotic disorders.
    Type: Grant
    Filed: January 22, 1988
    Date of Patent: May 16, 1989
    Assignee: Pfizer Inc.
    Inventors: John A. Lowe, III, Arthur A. Nagel
  • Quinazolinediones and pyridopyrimidinediones
    Patent number: 4797403
    Abstract: 1-Phenylquinazoline-1H,3H-2,4-diones and 1-phenylpyrido-[2,3d]-pyrimidine-1H,3H-2,4-diones, their esters and acid addition salts, and pharmaceutical compositions containing such compounds have antidepressant, anti-inflammatory and analgesic activity.
    Type: Grant
    Filed: July 23, 1987
    Date of Patent: January 10, 1989
    Assignee: Pfizer Inc.
    Inventor: John A. Lowe, III
  • Process for (1H)-isoindolin-1-one-3-carboxylic acid
    Patent number: 4730056
    Abstract: A process for preparing [1H]-isoindolin-1-one-3-carboxylic acid comprising the steps of (1) reacting phthalaldehydic acid in an alkanol with ammonia, (2) contacting the resulting solution with an alkali metal cyanide, (3) removing the alkanol, (4) adjusting the pH to 1.0, (5) heating the resulting reaction mixture until product formation is substantially complete and isolating the product.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: March 8, 1988
    Assignee: Pfizer Inc.
    Inventor: John A. Lowe, III