Abstract: Disclosed herein are non-human animals (e.g., rodents, e.g., mice or rats) genetically engineered to express a humanized or human T cell receptor (TCR) comprising a variable domain encoded by (a) at least one human TCR variable region ? gene segment and a (human) TCR ? constant region gene sequence and/or (b) or at least one human TCR variable region ? gene segment and a (human) TCR ? constant region gene sequence. Also provided are embryos, tissues, and cells expressing the same. Methods for making a genetically engineered animal that expresses the humanized or human ? and/or ? TCR are also provided. Methods for using the genetically engineered animals that mount a substantially humanized T cell immune response for developing human therapeutics are also provided.

Abstract: Methods are provided herein for assembling at least two nucleic acids using a sequence specific nuclease agent (e.g., a gRNA-Cas complex) to create end sequences having complementarity and subsequently assembling the overlapping complementary sequences. The nuclease agent (e.g., a gRNA-Cas complex) can create double strand breaks in dsDNA in order to create overlapping end sequences or can create nicks on each strand to produce complementary overhanging end sequences. Assembly using the method described herein can assemble any nucleic acids having overlapping sequences or can use a joiner oligo to assemble sequences without complementary ends.

Abstract: The present invention relates to shaker doors with solid cores and methods for making the same. The shaker doors contain different core materials at the recessed panel than the raise peripheral region to provide dimensional stability and reduced distortion when the doors are exposed to high humidity. The devices and methods also provide for easy assembly of solid core shaker doors, including fire rated doors.

Abstract: Provided herein are methods and compositions related to mice that express human or humanized Foot receptors (FcaR) from an FcaR locus positioned in the mouse leukocyte receptor complex (LRC). In certain embodiments, such mice are useful for in vivo testing of therapeutic agents comprising a human IgA Fc (e.g., the testing of the pharmacokinetic and/or pharmacodynamic properties of such therapeutic agents and dosing regimens). Also provided herein are methods of using such mice, cells from such mice, methods of making such mice, and ES cells comprising the same genetic modifications as such mice. Provided herein are methods and compositions related to mice that express human or humanized Foot receptors (FcaR) from an FcaR locus positioned in the mouse leukocyte receptor complex (LRC). In certain embodiments, such mice are useful for in vivo testing of therapeutic agents comprising a human IgA Fc (e.g.

Abstract: Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human VH gene segment, a plurality of human DH gene segments and a plurality of human JH gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.

Abstract: Systems and methods are provided to enable a partial migration of applications from one database system to another without modifying the applications. In embodiments, a proxy server is configured to monitor the application's usage of a current database, and generate a migration plan to partially migrate database objects used by the application to a different type of database. An object may be selected for migration based on its usage level or its portability. After the partial migration, the proxy server may remain in place as a request router to route the application's requests to the two databases. In embodiments, the migration system may forward queries to both databases and compare the query results received from the two. Based on the comparison results, the migration system may programmatically determine adjustments to its query handling configuration settings.

Abstract: An optical apparatus (10) for routing an optical signal (12) comprises a body (14) comprising a material. A waveguide (16) is formed in the body (14) by laser modification of the material. The optical apparatus (10) further comprises a region (18) comprising a lower refractive index than the material of the body (14) and defines an interface (24) between the region (18) and the waveguide (16). The waveguide (16) and the interface (24) are aligned relative to each other for routing the optical signal (12) therebetween and reflecting the optical signal (12) at the interface (24).

Abstract: An atmospheric greenhouse gas reduction system that includes greenhouse gas reduction particles having carbon dioxide conversion material that is capable of converting carbon dioxide in atmosphere into simple carbohydrates. The greenhouse gas reduction particles have a size of up to about 1,000 nanometers.

Abstract: A wireless charging system is configured to charge one or more receiver devices simultaneously. The wireless charging system includes multiple coils that may be driven independently based on a feedback system with one or more feedback channels. Each coil is driven by a coil driving signal selected based on a set of target characteristics. A coil drive circuit receives an input of a pulse width modulation (PWM) signal and outputs the coil driving signal to a corresponding coil.

Abstract: A method for monitoring a rotor assembly of a wind turbine includes receiving, via an imaging analytics module of a controller, thermal imaging data of the rotor assembly. The thermal imaging data includes a plurality of image frames. The method also includes automatically identifying, via a first machine learning model of the imaging analytics module, a plurality of sections of a rotor blade of the rotor assembly within the plurality of image frames until all sections of the rotor blade are identified. Further, the method includes selecting, via a function of the imaging analytics module, a subset of image frames from the plurality of image frames, the subset of image frames comprising a minimum number of the plurality of image frames required to represent all sections of the rotor blade. Moreover, the method includes generating, via a visualization module of the controller, an image of the rotor assembly using the subset of image frames.

Abstract: A system such as a service of a computing resource service provider includes executable code that, if executed by one or more processors, causes the one or more processors to identify a set of resources associated with a first database system, determine, based at least in part on the set of resources, an expected outcome of an operation of a second database system, and generate, executable code that, if executed, verifies an actual outcome of the operation of the second database system against the expected outcome. The system may be utilized as part of a database migration process where data from a first database system is transferred to a second database system.

Abstract: A wireless charging system is configured to charge one or more receiver devices simultaneously. The wireless charging system includes multiple coils that may be driven independently based on a feedback system with one or more feedback channels. One of the feedback channels may be demodulated communication signals from the one or more receiver devices. The demodulation may be performed by a communication demodulation circuit with configurable gain. The demodulated communication signals are processed for error correction at a bit level and a packet level, which improves accuracy despite presence of multiple receiver devices and noisy conditions.

Abstract: A wireless charging system is configured to charge one or more receiver devices simultaneously. The wireless charging system includes multiple coils that may be driven independently based on a feedback system with one or more feedback channels. One of the feedback channels may be a voltage and/or current measurement of coil driving signals from the coils that are indicative of receiver device presences on the wireless charging system. A coil driving signal may be sampled and processed using discrete Fourier transform to determine amplitude and phase information of the signal.

Abstract: The subject matter discussed herein relates to multi-modal image alignment to facilitate biopsy procedures and post-biopsy procedures. In one such example, prostate structures (or other suitable anatomic features or structures) are automatically segmented in pre-biopsy MR and pre-biopsy ultrasound images. Thereafter, pre-biopsy MR and pre-biopsy ultrasound contours are aligned. To account for non-linear deformation of the imaged anatomic structure, a patient-specific transformation model is trained via deep learning based at least in part on the pre-biopsy ultrasound images. The pre-biopsy ultrasound images that are overlaid with the pre-biopsy MR contours and based off the deformable transformation model are then aligned with the biopsy ultrasound images. Such real-time alignment using multi-modality imaging techniques provides guidance during the biopsy and post-biopsy system.

Abstract: An image inspection computing device is provided. The device includes a memory device and at least one processor. The at least one processor is configured to receive at least one sample image of a first component, wherein the at least one sample image of the first component does not include defects, store, in the memory, the at least one sample image, and receive an input image of a second component. The at least one processor is also configured to generate an encoded array based on the input image of the second component, perform a stochastic data sampling process on the encoded array, generate a decoded array, and generate a reconstructed image of the second component, derived from the stochastic data sampling process and the decoded array. The at least one processor is further configured to produce a residual image, and identify defects in the second component.

Abstract: There is disclosed a dispenser 10 for dispensing product objects, comprising: a main chamber 20 for storing product objects; and a portion dispensing mechanism for dispensing a portion comprising a plurality of project objects 40. The portion dispensing mechanism comprises a gate arrangement 36 and a collection chamber 24 which are configured for relative linear movement between a loading configuration and a dispensing configuration. In the loading configuration a plurality of product objects 40 within the main chamber 20 collect within the collection chamber 24 and the gate arrangement 36 prevents product objects 40 from being dispensed from the collection chamber 24. In the dispensing configuration the gate arrangement 36 prevents product objects within the main chamber 20 from entering the collection chamber 24 and a plurality of product objects are dispensed from the collection chamber.

Abstract: A system includes a computing platform having processing hardware, and a system memory storing a software code. The processing hardware is configured to execute the software code to identify a file transfer protocol among multiple file transfer protocols for transferring one or more file(s), to determine, using a test data sample and the file transfer protocol, one or more parameter(s) correlated with a time required for transferring the file(s) using the file transfer protocol, and to provide, based on the parameter(s), an algorithm for transferring the file(s) using the file transfer protocol. The processing hardware is further configured to perform, using the algorithm, a file transfer simulation of the file(s) using the file transfer protocol, to provide, using the file transfer simulation, data pooling parameters for transferring the file(s), and to estimate, based on the file transfer simulation and the data pooling parameters, an elapsed time for transferring the file(s).

Abstract: Data is migrated between a source database and a target database. The source database management system (“DBMS”) remains operational during the migration. A user selects the source DBMS and target DBMS, provides connection information used to connect to the database management systems and selects a virtual machine instance to perform the migration in conjunction with a database migration service. After the setup is complete, the virtual machine instance in conjunction with the database migration service performs data type transformations, and other operations, without user intervention. The database migration service also converts, without user intervention, the source schema and code to a format compatible with the target DBMS. Any code that is not converted is marked to assist the user of the database migration service identify where manual re-coding is required. The database migration service can also provide recommendations as to a target DBMS that is a suitable target DBMS.

Abstract: Provided are antibodies, or an antigen-binding fragment thereof, that binds human IL-21, These antibodies are useful in immunoassays of IL-21 levels, and/or in vivo, ex vivo or in vitro immunochemical and other imaging methods for determining the presence of IL-21 and/or quantifying IL-21 levels, and for diagnostic, prognostic and predictive purpose, and or optimizing therapeutic regimens in patients in which IL-21 signaling is implicated in pathogenesis.

Abstract: A system and method of braze resistance spot welding of an aluminum component to a galvanized steel component involve providing an aluminum-side electrode having a first tip defining a rounded shape, providing a galvanized steel-side electrode having a second tip defining a flat shape, depositing a braze filler material between the aluminum and galvanized steel components at a desired location for a spot weld, performing a pre-heat including providing a first current across the electrodes for a first period such that the braze filler melts and removes a portion of a zinc coating from the galvanized steel component, and after performing the pre-heat, performing a spot weld between the aluminum and galvanized steel components by providing a second current across the electrodes for a second period such that the aluminum melts and the galvanized steel does not melt, wherein the second current is greater than the first current.