Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A computer implemented method, comprising: receiving a first audio signal; identifying one or more portions of the first audio signal as corresponding to one or more pre-determined text sequences; identifying one or more portions of the first audio signal as corresponding to one or more new text sequences; performing a voice authentication on a first portion of the first audio signal identified as corresponding to a first pre-determined text sequence and performing a separate voice authentication on a second portion of the first audio signal identified as corresponding to a new text sequence.

Abstract: An authentication method, comprising: obtaining a string; receiving an audio signal; performing speech recognition on the audio signal to extract text; and performing authentication of a user, the authentication comprising: comparing the extracted text and the string; and performing voice authentication of the user based on the audio signal.

Abstract: The present invention provides an expandable fusion device capable of being installed inside an intervertebral disc space to maintain normal disc spacing and restore spinal stability, thereby facilitating an intervertebral fusion. In one embodiment, the fusion device includes a body portion, a first endplate, and a second endplate, the first and second endplates capable of being moved in a direction away from the body portion into an expanded configuration or capable of being moved towards the body portion into an unexpanded configuration. The fusion device is capable of being deployed and installed in both configurations.

Abstract: A pressure pulse system includes a stator, a rotor rotatably positioned in the stator, and a valve assembly configured to induce a pressure pulse in response to rotation of the rotor within the stator, wherein the valve assembly includes a first valve plate coupled to one of the stator and the rotor and including a flow passage, and a second valve plate coupled to the other of the stator or the rotor to which the first valve plate is not coupled and comprising a first flow passage and a second flow passage that is spaced from the first flow passage, wherein the valve assembly provides a first flowpath and a second flowpath between the flow passage of the first valve plate and the second flow passage of the second valve plate.

Abstract: A secondary battery is provided for cycling between a charged and a discharged state, the secondary battery including a battery enclosure, an electrode assembly, carrier ions, a non-aqueous liquid electrolyte within the battery enclosure, and a set of electrode constraints. The set of electrode constraints includes a primary constraint system having first and second primary growth constraints and at least one primary connecting member, the first and second primary growth constraints separated from each other in the longitudinal direction, wherein the primary constraint array restrains growth of the electrode assembly in the longitudinal direction such that any increase in the Feret diameter of the electrode assembly in the longitudinal direction over 20 consecutive cycles of the secondary battery is less than 20%.

Abstract: Presented herein are techniques for indexing of nucleic acid, e.g., for use in conjunction with sequencing. The techniques include generating indexed nucleic acid fragments from an individual sample, whereby the index sequence incorporated into each index site of the nucleic acid fragment is selected from a plurality of distinguishable of index sequences and such that the population of generated nucleic acid fragments represents each index sequence from the plurality. In this manner, the generated indexed nucleic acid fragments from a single sample are indexed with a diverse mix of index sequences that reduce misassignment due to index read errors associated with low sequence diversity.

Abstract: Systems and methods for personalizing medicine utilizing the true state of the patient are provided. A number of medical records for a patient are subjected to predictive modeling for various conditions (known as patient ‘true state’). The patient personal information, previous care, and true state may be provided into a state machine in order to determine the resources needed for the patient. The medical resources may be any of laboratory services, diagnostics, therapies and medications. Using the true state information, and number of activities may be performed for the patient based upon the patient's needs. These activities include scheduling lab or diagnostic procedures in advance of an appointment, filling in documentation gaps, identifying items that require additional documentation using the true state, and tracking follow-up. It may also be beneficial to validate the true state.

Abstract: A stator vane includes a platform that defines an opening. The stator vane further includes an airfoil that has a leading edge, a trailing edge, a suction side wall, and a pressure side wall. The airfoil extends radially between a base and a tip. At least one of the base or the tip includes a protrusion. The protrusion extends into the opening of the platform such that the platform surrounds the protrusion of the airfoil. The stator vane further includes a braze joint disposed between and fixedly coupling the platform and the protrusion of the airfoil. The stator vane further includes a cooling circuit defined in at least one of the protrusion or the platform to cool the braze joint.

Abstract: The present invention relates to processes for producing fermentation products from starch-containing material, wherein a thermostable alpha-amylase and optionally a thermostable protease are present and/or added during liquefaction. The invention also relates to a composition suitable for use in a process of the invention.

Abstract: A fuel tank comprises an interior wall, a sump, and a baffle that comprises a center fitting, a full-length containment petal, a partial-length containment petal, a dump tube. The full-length containment petal comprises a full-length side edge, extending radially outward from the center fitting. The partial-length containment petal comprises a partial-length side edge, extending radially outward from the center fitting. The dump tube is connected to the sump. The full-length side edge of the full-length containment petal is longer than the partial-length side edge of the partial-length containment petal. All of the partial-length side edge of the partial-length containment petal is attached to a linear portion of the full-length side edge of the full-length containment petal.

Abstract: Presented herein are techniques to shield transmissions from being received and the information contained in them recovered by unwanted devices. Multi-user multiple-input multiple-output (MU-MIMO) techniques are employed, and in particular the spatial dimension aspects of those techniques. Shield nodes are controlled to transmit in a way to obscure the downlink streams transmitted by a wireless access point that are intended for a particular client device to anything outside of the shielded area, and also to obscure uplink streams from one or more client devices to the wireless access point to anything outside of the shielded area but allowing the uplink streams to be well received by the wireless access point.

Abstract: An expandable intervertebral implant having an upper body portion, a lower body portion opposite the upper body portion. a wedge member connecting the upper body portion to the lower body portion, a nose member having a tapered distal end and a proximal end opposite the distal end, and an actuator disposed between the nose member and the wedge member, for translation of the wedge member along a longitudinal axis of the implant. A pin disposed in a center of the nose member connects to the actuator for centering the nose member with the actuator. Translation of the wedge member along the longitudinal axis of the implant displaces the upper body portion and the lower body portion away from each other, thereby expanding the intervertebral implant.

Abstract: A transfer key system for a vehicle may include a key receptacle configured to detect the presence of a transfer key, and a controller configured to receive key status signals from the key receptacle, and activate the transfer key as an active transfer key in response to the status signal indicating a removal of the transfer key from the key receptacle and receiving an authentication signal from a user.

Abstract: Various embodiments are disclosed for improved and structurally optimized transistors, such as RF power amplifier transistors. A transistor may include a drain metal portion raised from a surface of a substrate, a drain metal having a notched region, a gate manifold body with angled gate tabs extending from the gate manifold, and/or a source-connected shielding. The transistor may include a high-electron-mobility transistor (HEMT), a gallium nitride (GaN)-on-silicon transistor, a GaN-on-silicon-carbide transistor, or other type of transistor.

Abstract: Systems and methods for targeted advertising to specific consumers are disclosed. A system may include a memory storing instructions; and at least one processor configured to execute the instructions to: receive, over a network, consumer data from a client device; identify a plurality of client-provided consumers from the consumer data; obtain a plurality of unique consumer identifiers corresponding to the plurality of client-provided consumers; and identify at least one first overlapping unique consumer identifier by matching at least one of the plurality of client-provided consumers with at least one publisher-provided consumer provided by a first publisher device of a plurality of publisher devices, the first publisher device having a highest priority among the plurality of publisher devices.

Abstract: An expandable screw for orthopedic insertion and expansion between a collapsed state and an expanded state. The screw has an upper externally-threaded body segment, a lower externally-threaded body segment opposite the upper external thread segments, and an expansion member extending along a longitudinal axis thereof. The expansion member connecting the upper externally-threaded body segment to the lower externally-threaded body segment, and configured during the expansion between the collapsed state and the expanded state to separate the upper externally-threaded body segment from the lower externally-threaded body segment.

Abstract: Disclosed herein are methods, systems, and processes to detect rogue wireless access points and determine their approximate location in a geospatial location. Wireless access point data collected from wireless access points by fixed sensor nodes and agent-based sensor nodes in a geospatial location is received. A wireless site survey is performed at the geospatial location based on the wireless access point data. Based on the wireless site survey, an approximate location of a rogue wireless access point at the geospatial location is determined.

Abstract: Motion and video data from vehicle sensors and camera arrays attached to a vehicle collect video and sensor data along a path driven by the vehicle. A system processes such data to produce high-accuracy structured map data, as might be used to precisely locate a moving vehicle in its environment. Positions are calculated from the sensor data. The positions are updated based on the video data. Positions of features in the video are used to create or update structured map data.