Abstract: A casting mould comprising: an inorganic or refractory mould, wherein the mould is configured to receive feedstock; wherein the feedstock is configured to be heated in situ. A reusable mould, reusable susceptor, and/or release agent may be incorporated. Method of manufacturing a mould, and casting a part employing 5 in situ heating, are also provided.

Abstract: The present invention relates to efficient synthetic processes useful in the preparation of uridine, which is useful in the production of nucleosides and nucleotides that may be active as antiviral agents, as well as compositions and methods thereof.

Abstract: The present invention relates to efficient synthetic processes useful in the preparation of antiviral nucleosides, particularly uridine 4-oxime 5?-(2-methylpropanoate) {(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl]oxolan-2-yl}methyl 2-methylpropanoate and pharmaceutically acceptable salts, derivatives, tautomers, isomers, and prodrugs of, which may be active as antiviral agents, as well as compositions and methods thereof. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

Abstract: The present disclosure provides MTR kinase polypeptides having improved properties as compared to a naturally occurring wild-type MTR kinase polypeptide including the capability of phosphorylating D-ribose and 5?-D-isobutyrylribose to give alpha-D-ribose-1-phosphate and alpha 5?-D-isobutyrylribose-1-phosphate. Also provided are polynucleotides encoding the MTR kinase polypeptides, host cells capable of expressing the MTR kinase polypeptides, and methods of using the MTR kinase polypeptides to synthesize alpha-D-ribose-1-phosphate and alpha 5?-D-isobutyrylribose-1-phosphate.

Abstract: The disclosure provides a novel process and synthetic intermediates for making belzutifan, a HIF-2a inhibitor, useful for the treatment of certain VHL-related indications and cancer.

Abstract: The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing N-(7-((2S,4R,5R)-4-fluoro-3,3-dihydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[3,2-d]pyrimidin-2-yl)isobutyramide. Also provided are polynucleotides encoding the ketoreductase enzymes, host cells capable of expressing the ketoreductase enzymes, and methods of using the ketoreductase enzymes to synthesize N-(9-((2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide.

Abstract: A fluid removal system for removing fluid from a product stream is described herein. The fluid removal system comprises a table, a permeable conveyor to transport the product stream across a top surface of the table and a plenum disposed below the permeable conveyor to draw the fluid from the product stream through the permeable conveyor. At least one vibration inducing mechanism is mounted to the table to provide vibratory motion directly to the table and indirectly to the conveyor. The table is supported by oscillating mounts that provide oscillatory motion to the table.

Abstract: Password Hidden Characters is a security method which creates characters which are invisible. It is a method comprising steps used to insert time intervals between specific password characters, or to replace characters which have been withdrawn from the password or message, with the objective being to disguise a true password or message meant to be secret, and by so doing to create an invisible code. The invisible code allows messages which are supposed to be secret to remain that way. This protection evolves from the withdrawal of any six characters out of a total of 26 available, and the number of permutations created when this is done.

Abstract: Password Hidden Characters is a security method which creates characters which are invisible. It is a method comprising steps used to insert time intervals between specific password characters, or to replace characters which have been withdrawn from the password or message, with the objective being to disguise a true password or message meant to be secret, and by so doing to create an invisible code. The invisible code allows messages which are supposed to be secret to remain that way. This protection evolves from the withdrawal of any six characters out of a total of 26 available, and the number of permutations created when this is done.

Abstract: A fluid removal system for removing fluid from a product stream is described herein. The fluid removal system comprises a table, a permeable conveyor to transport the product stream across a top surface of the table and a plenum disposed below the permeable conveyor to draw the fluid from the product stream through the permeable conveyor. At least one vibration inducing mechanism is mounted to the table to provide vibratory motion directly to the table and indirectly to the conveyor. The table is supported by oscillating mounts that provide oscillatory motion to the table.

Abstract: The disclosure generally relates to the fields of synthetic organic chemistry. In particular, the present disclosure relates to methods and systems for the imidation of sulfides.

Abstract: A fluid removal system for removing fluid from a product stream is described herein. The fluid removal system comprises a table, a permeable conveyor to transport the product stream across a top surface of the table and a plenum disposed below the permeable conveyor to draw the fluid from the product stream through the permeable conveyor. At least one vibration inducing mechanism is mounted to the table to provide vibratory motion directly to the table and indirectly to the conveyor. The table is supported by oscillating mounts that provide oscillatory motion to the table.

Abstract: The present invention provides methods by which trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine and related cyclopropane compounds are prepared using synthetic strategies that include a biocatalytic cyclopropanation step.

Abstract: The disclosure generally relates to the fields of synthetic organic chemistry. In particular, the present disclosure relates to methods and systems for the imidation of sulfides.

Abstract: The disclosure generally relates to the fields of synthetic organic chemistry. In particular, the present disclosure relates to methods and systems for the imidation of sulfides.

Abstract: The disclosure generally relates to the fields of synthetic organic chemistry. In particular, the present disclosure relates to methods and systems for the imidation of sulfides.

Abstract: The invention relates to a coal dewatering system, method and apparatus. The dewatering system includes a preheater vessel (82) having a chamber (101) for heating coal, an inlet (84) to permit the passage of coal into the chamber (101), and an outlet (86) for permitting the passage of coal from the chamber (101). The dewatering vessel also includes a heating mechanism (98) associated with the preheater vessel (82) to heat coal contained in the chamber (101) and a non-return valve (92) to substantially prevent heated coal removed from the preheater chamber (101) via the outlet (86) from re-entering the preheater vessel (82) via the outlet (86). The dewatering system further includes a dewatering unit (60) adapted to receive the heated coal from the outlet (86) via the non-return valve (92) and to thereby dewater the coal.

Abstract: A golf club head has two metal outer ends to and a mid-section composed of multiple side-by-side, polymeric laminations (14) directed substantially transversely to the club face (4). In one version the threaded rod (12) joins the ends compressing the laminations. The laminations allow bands of color or opacity to create a distinctive appearance. In another version the laminations are replaced by a moulded block of polymer (24).

Abstract: A system (10) for monitoring and controlling a fabrication process includes at least a first subsystem (12), a crystallographic analysis subsystem (14), and a second subsystem (16), wherein the first subsystem and second subsystem perform respective fabrication steps on a workpiece. The crystallographic analysis subsystem may be coupled to both the first subsystem and second subsystem. The analysis subsystem acquires crystallographic information from the workpiece after the workpiece undergoes a fabrication step by the first subsystem and then provides information, based on the crystallographic information acquired, for modifying parameters associated with the respective fabrication steps. The system may also include neural networks (24, 28) to adaptively modify, based on historical process data (32), parameters provided to the respective fabrication steps. The analysis subsystem may include a electromagnetic source (61), a detector (66), a processor (67), a controller (68) and a scanning actuator (65).

Abstract: The invention relates to a coal dewatering system, method and apparatus. The dewatering system includes a preheater vessel (82) comprising a chamber (101) for heating coal, an inlet means (84) to permit the passage of coal into the chamber (101), and an outlet means (86) for permitting the passage of coal from the chamber (101). The dewatering vessel also includes a heating means (98) associated with the preheater vessel (82) to heat coal contained in the chamber (101) and a non-return valve means (92) to substantially prevent heated coal removed from the preheater chamber (101) via the outlet means (86) from re-entering the preheater vessel (82) via the outlet means (86). The dewatering system further including a dewatering unit (60) adapted to receive the heated coal from the outlet means (86) via the non-return valve means (92) and to thereby dewater the coal.