Abstract: A coupling shell including a top wall, a shell wall, a front aperture in the top wall, a dispensing opening in the top wall, and a neck fitment projecting into the shell interior of the shell wall. The coupling shell can provide for a connection between a container and a dispensing system.

Abstract: For a communication channel having a first endpoint in a customer on-premise network and a second endpoint on a primary host machine in a cloud service provider infrastructure, the primary host machine determines a change in a state information of the communication channel and identifies a backup host machine for the communication channel. The primary host machine causes the change in the state information to be replicated to the backup host machine, wherein the replicated state information stored by the backup host machine is usable by the backup host machine after a failover causes the backup host machine to become the second endpoint of the communication channel.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods for generating a video of a user-defined virtual reality scene are disclosed. Exemplary implementations may: obtain a scene definition; obtain camera information for multiple virtual cameras to be used in generating a two-dimensional presentation of the virtual reality scene; execute a simulation of the virtual reality scene from the scene definition for at least a portion of the scene duration; obtain camera timing instructions specifying which of the virtual cameras should be used to generate the two-dimensional presentation of the virtual reality scene as a function of progress through the scene duration; generate the two-dimensional presentation of the virtual reality scene in accordance with the camera timing instructions and the camera information.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: A glass container for storing pharmaceutical formulations may include a glass body formed from a Type IA or Type IB glass composition according to ASTM Standard E438-92(2011). The glass body may include a wall portion with an inner surface and an outer surface, a heel portion and a floor portion, wherein the inner surface of the glass container is formed by the inner surface of the glass body. The glass body may include at least a class A2 base resistance or better according to ISO 695, at least a type HGB2 hydrolytic resistance or better according to ISO 719 and Type 1 chemical durability according to USP <660>. The glass container does not comprise a boron-rich layer on the inner surface of the glass body in as formed condition.

Abstract: A valve actuation system comprises a first arm having a first arm contact surface and operatively connected to a valve actuation motion. A second arm having a second arm contact surface is operatively connected to the at least one engine valve. A discrete lost motion device is provided that is controllable between a first, motion conveying state and a second, motion absorbing state. The discrete lost motion devices comprises a plunger contact surface and a housing contact surface. The housing contact surface is configured to engage one of the first or second arm contact surfaces, and the plunger contact surface is configured to engage another of the first and the second arm contact surfaces. The first and second arm contact surfaces, the housing contact surface and the first plunger contact surface are configured to support the discrete lost motion device between the first arm and the second arm.

Abstract: Disclosed are methods for coating aluminum alloy heat exchangers that include the use of a waterborne top coating. By using a waterborne top coating, relative to a solvent borne, useful advantages can be achieved, such as improved penetration depth of the top coating. An example method includes cleaning a surface of a heat exchanger; contacting the surface of the heat exchanger with a first mixture to provide a passivation layer on the surface of the heat exchanger; contacting the passivation layer with a second mixture in a bath and applying a positive charge to the bath to provide an electro-coating on a surface of the passivation layer; and contacting the electro-coating with a third mixture, the third mixture including water and a polymer resin having anti-corrosion and ultraviolet protection properties, to provide a top coating including the polymer resin on a surface of the electro-coating.

Abstract: An approach for facilitating mechanical and electrical connection of electric machines and electrical components in an electrical system using connectors with quick connect/disconnect electrical connectors is disclosed. Each quick connect/disconnect electrical connector can be placed on the end of an electrical power distribution cable that connects with an electric machine or electrical component. The electric machines and electrical components and the electrical power distribution cables can have hollow coolant passages formed therein to receive cooling fluid from a cooling device for direct cooling of the electric machines, electrical components and the electrical power distribution cables.

Abstract: A discrete lost motion device for use in a valve train of an internal combustion engine comprises a housing having a housing bore extending longitudinally into the housing and a second end having a housing contact surface configured to engage a corresponding contact surface of a first valve train component. A plunger slidably is disposed in the housing bore is controllable between a first state in which the plunger rigidly extends out of the housing bore and a second state in which the plunger is permitted to reciprocate within the housing bore, the plunger further comprising an end having a plunger contact surface configured to engage a corresponding contact surface of a second valve train component. The housing contact surface and the plunger contact surface are configured to support the discrete lost motion device between the first and second valve train components.

Abstract: An apparatus for at least one of diagnosing or treating an eye condition can include a goggle enclosure, sized and shaped to be seated on an eye socket of an eye to provide one or more cavities within the enclosure that extend about an entire exposed anterior portion of the eye, a pump, in fluidic communication with the one or more cavities to apply a fluid pressure to the one or more cavities, the pump configured to adjust a fluid pressure within the one or more cavities of the goggle enclosure, and a control circuit, including a data interface to receive data directly or indirectly indicating at least one of an intraorbital pressure, ICP, IOP, or a relationship between ICP and IOP, and based on processing the received data as a feedback control variable, controlling the pump to adjust the fluid pressure within the one or more cavities, the controlling including using further monitoring of the received data to control the pump.

Abstract: A materialization configuration request is received via a programmatic interface from a client of a journal-based multi-data-store database. The request indicates a partitioning rule to be used to select, for respective writes indicated in committed transaction entries of a journal, the materialization node at which the writes are to be stored. A control plane component of the database verifies that a set of materialization nodes corresponding to the partitioning rule has been established, and initiates the propagation of writes from the journal to the materialization nodes by respective write appliers.

Abstract: Disclosed is a method for controlling the speed of a vehicle, the method comprising: determining a speed limit; determining an offset value based on (i) the speed limit, and (ii) a speed map, the speed map comprising a plurality of entries, each entry associating one of the offset values with a respective speed limit; and setting the speed of the vehicle according to the speed limit and the determined offset value.

Abstract: An apparatus is provided to test valves. The apparatus includes an actuation mechanism having an actuator that seals a valve of a combustion chamber of an engine. The apparatus further includes a flow control device that controls a flow of a pressurized fluid to the combustion chamber. The apparatus further includes a plurality of sensors having a first sensor and a second sensor. The first sensor is disposed in an inlet port of the combustion chamber to detect a first flow rate of the pressurized fluid in the inlet port. The second sensor is disposed in an exhaust port of the combustion chamber to detect a second flow rate of the pressurized fluid in the exhaust port. The apparatus further includes a notification device configured to generate an alert based on the detected first flow rate and the detected second flow rate.

Abstract: A user equipment (UE) is described. Higher layer circuitry is configured to receive information on a sidelink bandwidth part and a resource pool for sidelink within the sidelink bandwidth part. Transmitting circuitry is configured to transmit one or more blocks. Each block includes a primary sidelink synchronization signal (PSSS), a secondary sidelink synchronization signal(SSSS), a physical sidelink broadcast channel (PSBCH) and a demodulation reference signal (DMRS) associated with the PSBCH within the resource pool. A sequence of the PSSS is generated by using a synchronization source identity (ID) or a part of the synchronization source ID. A sequence of the SSSS is generated by using the synchronization source ID or a part of the synchronization source ID. The PSBCH includes a parameter related to an index of the block and the parameter is associated with a slot index.

Abstract: A system and method automatically models online job applications provides assistance to job applicants completing the job applications. Initially, as job applicants complete online job applications, their previously collected personal profile is concurrently displayed for those job applicants to select data fields from that personal profile for use in filling out specific data fields in the job applications. This selection and use of personal profile information for completing the job applications is monitored and data points are generated and stored documenting the data fields the job applicants selected from the personal profiles and the associated data fields where those selected personal profile data fields are utilized to complete job applications. Data points are generated and stored documenting the data field associations, the data points are utilized to identify associations, and the associations are stored as models to be utilized to provide assistance to other job applicants.

Abstract: One example method of operation may include identifying a call originated from a caller entity destined for a called entity at a call content server, identifying a called number associated with the called entity and a caller number associated with the caller entity, comparing a telephone number prefix associated with the called number with a number of enhanced call content data elements to identify a match, selecting one or more of the enhanced call content data elements to pair with the called number based on the match, and forwarding the selected enhanced call content data elements to the called entity.

Abstract: The present disclosure relates to methods and systems for automatically providing a suggestion to delay sending a message that is being composed by a user to send to a chat participant using a chat feature of an application. The suggestion is sent in response to determining that one or more trigger conditions occurred. The suggestion includes a scheduled time to send the message. The methods and systems send the delayed message at the scheduled time.