Abstract: Provided herein are drug delivery devices, comprising a scaffold comprising one or more biocompatible materials, one or more chambers containing a plurality of cells, one or more membranes, and one or more nutrient supplementation systems. Also provided are methods of treating or preventing diseases and disorders in a subject in need thereof, comprising administering to the subject the drug delivery devices disclosed herein, and methods of making the drug delivery devices disclosed herein.

Abstract: Disclosed herein are buccal implant devices comprising a body having a non-cylindrical geometry, the body adapted to be disposed within the oral cavity of a patient (e.g., the oral mucosa of a patient), and one or more pharmaceutically active ingredients. Also disclosed are methods of using the buccal implant devices in treating or preventing medical conditions.

Abstract: Embodiments include a lighting assembly includes an elongate gasket body formed of a resilient, optically transmissive material. The gasket body includes a light source cavity at least partially defined by a light transmission portion and an attachment channel configured to attach the gasket body to a mount. A light source is disposed in the light source cavity. Other embodiments include securement ring including a clamp portion and a lighting assembly portion. The clamp portion includes first and second segments, each being semiannular in shape and curving between first and second ends, the first end of the first segment coupled to the second end of the second segment and the second end of the first segment coupled to the first end of the second segment to collectively form an aperture. The lighting assembly portion includes a first and second segments, each being semiannular in shape and including a light source.

Abstract: Knuckle joint assembly for a medical device support system. The knuckle joint assembly includes a cartridge assembly that includes a cartridge housing and a rotary bearing. The cartridge housing includes a bore having a central axis and a bearing mount in the bore. The rotary bearing is press fitted in the bearing mount and configured to receive axially therethrough a spindle to rotatably support the spindle about the central axis. The knuckle joint assembly includes a retaining clip and a retaining pin. The retaining clip is selectively movable to disengage and engage a groove in a spindle to respectively support or release the spindle along a central axis. The retaining pin is movable between a first position to allow movement of the retaining clip between positions but prevent removal of the retaining clip, and a second position to block movement of the retaining clip from the engaged position.

Abstract: This disclosure is related to the use of a peptide with antimicrobial properties. The peptide is administered topically via nasal or pulmonary delivery to prevent or treat respiratory diseases caused by viruses. A variety of formulations and uses are described as well as methods of manufacture thereof. The formulations are safe and useful in patients—both humans and animals—for the delivery of appropriate bioactive substance(s) to the respiratory system.

Abstract: A medical device suspension system includes a spindle extending along a longitudinal axis and a cable management cover surrounding the spindle. A gap is formed between the cable management cover and the spindle. A hub is rotatably mounted to the spindle and includes a housing. A top hub cover is disposed along the longitudinal axis between the hub and the cable management cover and defines an end of the gap, the top hub cover including a passage in fluid communication with an internal volume of the housing. The top hub cover is rotatable with respect to the spindle about the longitudinal axis. A cable is provided within the gap, the cable entering the gap at a fixed location about the longitudinal axis and passing into the housing through the passage. Rotation of the top hub cover about the longitudinal axis causes the passage to rotate about the longitudinal axis.

Abstract: Knuckle joint assembly for a medical device support system. The knuckle joint assembly includes a cartridge assembly that includes a cartridge housing and a rotary bearing. The cartridge housing includes a bore having a central axis and a bearing mount in the bore. The rotary bearing is press fitted in the bearing mount and configured to receive axially therethrough a spindle to rotatably support the spindle about the central axis. The knuckle joint assembly includes a retaining clip and a retaining pin. The retaining clip is selectively movable to disengage and engage a groove in a spindle to respectively support or release the spindle along a central axis. The retaining pin is movable between a first position to allow movement of the retaining clip between positions but prevent removal of the retaining clip, and a second position to block movement of the retaining clip from the engaged position.

Abstract: This disclosure relates to the use of an implantable device to deliver biologically active compounds at a controlled rate for an extended period of time and methods of manufactures thereof. The device is biocompatible and biostable, and is useful as an implant in patients (humans and animals) for the delivery of appropriate bioactive substances to tissues or organs.

Abstract: Knuckle joint assembly for a medical device support system. The knuckle joint assembly includes a cartridge assembly that includes a cartridge housing and a rotary bearing. The cartridge housing includes a bore having a central axis and a bearing mount in the bore. The rotary bearing is press fitted in the bearing mount and configured to receive axially therethrough a spindle to rotatably support the spindle about the central axis. The knuckle joint assembly includes a retaining clip and a retaining pin. The retaining clip is selectively movable to disengage and engage a groove in a spindle to respectively support or release the spindle along a central axis. The retaining pin is movable between a first position to allow movement of the retaining clip between positions but prevent removal of the retaining clip, and a second position to block movement of the retaining clip from the engaged position.

Abstract: Embodiments include a lighting assembly includes an elongate gasket body formed of a resilient, optically transmissive material. The gasket body includes a light source cavity at least partially defined by a light transmission portion and an attachment channel configured to attach the gasket body to a mount. A light source is disposed in the light source cavity. Other embodiments include securement ring including a clamp portion and a lighting assembly portion. The clamp portion includes first and second segments, each being semiannular in shape and curving between first and second ends, the first end of the first segment coupled to the second end of the second segment and the second end of the first segment coupled to the first end of the second segment to collectively form an aperture. The lighting assembly portion includes a first and second segments, each being semiannular in shape and including a light source.

Abstract: Embodiments include a lighting assembly includes an elongate gasket body formed of a resilient, optically transmissive material. The gasket body includes a light source cavity at least partially defined by a light transmission portion and an attachment channel configured to attach the gasket body to a mount. A light source is disposed in the light source cavity. Other embodiments include securement ring including a clamp portion and a lighting assembly portion. The clamp portion includes first and second segments, each being semi-annular in shape and curving between first and second ends, the first end of the first segment coupled to the second end of the second segment and the second end of the first segment coupled to the first end of the second segment to collectively form an aperture. The lighting assembly portion includes a first and second segments, each being semi-annular in shape and including a light source.

Abstract: Embodiments include a lighting assembly includes an elongate gasket body formed of a resilient, optically transmissive material. The gasket body includes a light source cavity at least partially defined by a light transmission portion and an attachment channel configured to attach the gasket body to a mount. A light source is disposed in the light source cavity. Other embodiments include securement ring including a clamp portion and a lighting assembly portion. The clamp portion includes first and second segments, each being semi-annular in shape and curving between first and second ends, the first end of the first segment coupled to the second end of the second segment and the second end of the first segment coupled to the first end of the second segment to collectively form an aperture. The lighting assembly portion includes a first and second segments, each being semi-annular in shape and including a light source.

Abstract: A medical device suspension system includes a spindle extending along a longitudinal axis and a cable management cover surrounding the spindle. A gap is formed between the cable management cover and the spindle. A hub is rotatably mounted to the spindle and includes a housing. A top hub cover is disposed along the longitudinal axis between the hub and the cable management cover and defines an end of the gap, the top hub cover including a passage in fluid communication with an internal volume of the housing. The top hub cover is rotatable with respect to the spindle about the longitudinal axis. A cable is provided within the gap, the cable entering the gap at a fixed location about the longitudinal axis and passing into the housing through the passage. Rotation of the top hub cover about the longitudinal axis causes the passage to rotate about the longitudinal axis.

Abstract: Knuckle joint assembly for a medical device support system. The knuckle joint assembly includes a cartridge assembly that includes a cartridge housing and a rotary bearing. The cartridge housing includes a bore having a central axis and a bearing mount in the bore. The rotary bearing is press fitted in the bearing mount and configured to receive axially therethrough a spindle to rotatably support the spindle about the central axis. The knuckle joint assembly includes a retaining clip and a retaining pin. The retaining clip is selectively movable to disengage and engage a groove in a spindle to respectively support or release the spindle along a central axis. The retaining pin is movable between a first position to allow movement of the retaining clip between positions but prevent removal of the retaining clip, and a second position to block movement of the retaining clip from the engaged position.

Abstract: The present invention provides for a drug delivery device. The device can comprise at least one core with a first active pharmaceutical ingredient (API), coated with a first layer that is permeable or semi-permeable to the API, coated with a second layer that is impermeable to the API and having a delivery window to allow passage of the API through the device and into body fluids or tissues. The device can also have a wicking material to modify the rate of transport of the API into the body fluid or tissues.

Abstract: A brake screw for use with a surgical lighting system. The brake screw includes a screw member retained within a threaded aperture of a mounting hub of a spindle of an arm used with the lighting system. The screw member is rotationally adjusted to enable displacement in an axial direction. A brake member is in axial alignment with the screw member and disposed for movement in the axial direction against a mounting tube retained within the mounting hub upon rotational adjustment of the screw member. A rivet section is integrally formed with the brake member and has a distal end retained within an axial recess formed within the screw member, allowing movement of the brake member in the axial direction within the screw member. A bias member is disposed between the screw member and the brake member to create a biasing force that urges apart the screw member and the brake member along the axial direction.

Abstract: The present invention provides for a drug delivery device. The device can comprise at least one core with a first active pharmaceutical ingredient (API), coated with a first layer that is permeable or semi-permeable to the API, coated with a second layer that is impermeable to the API, and having a delivery window to allow passage of the API through the device and into body fluids or tissues. The device can also have a wicking material to modify the rate of transport of the API into the body fluid or tissues.

Abstract: A brake screw for use with a surgical lighting system. The brake screw includes a screw member retained within a threaded aperture of a mounting hub of a spindle of an arm used with the lighting system. The screw member is rotationally adjusted to enable displacement in an axial direction. A brake member is in axial alignment with the screw member and disposed for movement in the axial direction against a mounting tube retained within the mounting hub upon rotational adjustment of the screw member. A rivet section is integrally formed with the brake member and has a distal end retained within an axial recess formed within the screw member, allowing movement of the brake member in the axial direction within the screw member. A bias member is disposed between the screw member and the brake member to create a biasing force that urges apart the screw member and the brake member along the axial direction.

Abstract: The present invention provides for a drug delivery device. The device can comprise at least one core with a first active pharmaceutical ingredient (API), coated with a first layer that is permeable or semi-permeable to the API, coated with a second layer that is impermeable to the API, and having a delivery window to allow passage of the API through the device and into body fluids or tissues. The device can also have a wicking material to modify the rate of transport of the API into the body fluid or tissues.

Abstract: The present invention provides for a drug delivery device. The device can comprise at least one core with a first active pharmaceutical ingredient (API), coated with a first layer that is permeable or semi-permeable to the API, coated with a second layer that is impermeable to the API, and having a delivery window to allow passage of the API through the device and into body fluids or tissues. The device can also have a wicking material to modify the rate of transport of the API into the body fluid or tissues.