Abstract: Provided herein are drug delivery devices, comprising a scaffold comprising one or more biocompatible materials, one or more chambers containing a plurality of cells, one or more membranes, and one or more nutrient supplementation systems. Also provided are methods of treating or preventing diseases and disorders in a subject in need thereof, comprising administering to the subject the drug delivery devices disclosed herein, and methods of making the drug delivery devices disclosed herein.

Abstract: Disclosed herein are buccal implant devices comprising a body having a non-cylindrical geometry, the body adapted to be disposed within the oral cavity of a patient (e.g., the oral mucosa of a patient), and one or more pharmaceutically active ingredients. Also disclosed are methods of using the buccal implant devices in treating or preventing medical conditions.

Abstract: This disclosure is related to the use of a peptide with antimicrobial properties. The peptide is administered topically via nasal or pulmonary delivery to prevent or treat respiratory diseases caused by viruses. A variety of formulations and uses are described as well as methods of manufacture thereof. The formulations are safe and useful in patients—both humans and animals—for the delivery of appropriate bioactive substance(s) to the respiratory system.

Abstract: This disclosure relates to the use of an implantable device to deliver biologically active compounds at a controlled rate for an extended period of time and methods of manufactures thereof. The device is biocompatible and biostable, and is useful as an implant in patients (humans and animals) for the delivery of appropriate bioactive substances to tissues or organs.

Abstract: The present invention provides for a drug delivery device. The device can comprise at least one core with a first active pharmaceutical ingredient (API), coated with a first layer that is permeable or semi-permeable to the API, coated with a second layer that is impermeable to the API and having a delivery window to allow passage of the API through the device and into body fluids or tissues. The device can also have a wicking material to modify the rate of transport of the API into the body fluid or tissues.

Abstract: The present invention provides for a drug delivery device. The device can comprise at least one core with a first active pharmaceutical ingredient (API), coated with a first layer that is permeable or semi-permeable to the API, coated with a second layer that is impermeable to the API, and having a delivery window to allow passage of the API through the device and into body fluids or tissues. The device can also have a wicking material to modify the rate of transport of the API into the body fluid or tissues.

Abstract: The present invention provides for a drug delivery device. The device can comprise at least one core with a first active pharmaceutical ingredient (API), coated with a first layer that is permeable or semi-permeable to the API, coated with a second layer that is impermeable to the API, and having a delivery window to allow passage of the API through the device and into body fluids or tissues. The device can also have a wicking material to modify the rate of transport of the API into the body fluid or tissues.

Abstract: The present invention provides for a drug delivery device. The device can comprise at least one core with a first active pharmaceutical ingredient (API), coated with a first layer that is permeable or semi-permeable to the API, coated with a second layer that is impermeable to the API, and having a delivery window to allow passage of the API through the device and into body fluids or tissues. The device can also have a wicking material to modify the rate of transport of the API into the body fluid or tissues.

Abstract: A means of miniaturizing the rugged, spectroscopic gas analyzer for rapid, non-invasive, multicomponent analysis of breath described in application Ser. No. 09/891,106, Filed on Jun. 25, 2001. A significant (ca. 4×) reduction in analyzer dimensions is achieved through a redesign of the optical bench: single detectors of IR radiation are replaced by detector arrays. A number of embodiments are discussed.

Abstract: A furnace for treating granular activated carbon comprises a single vertical column having a pair of electrodes arranged at vertically spaced locations within the column. The electrodes extend across the column and are so constructed that the particulate material can pass with ease through the electrodes. Suitable connectors connect the electrodes to a source of rectified three phase electric power. Pointed prongs are provided below the upper electrode. A valve controls the outlet from the column so that the furnace can operate continuously. A central cone is provided above the outlet to control the flow of granular carbon down the column.