Abstract: In some embodiments, a system includes an applicator pad, an application device (e.g., a grip), and a reservoir. The grip can be releasably couplable to the applicator pad and configured to dispose the applicator pad against a wound of a subject such that pressure can be transferred to the wound via the applicator pad to enhance hemostasis. The reservoir can be configured to contain medication to be released to the wound via the applicator pad.

Abstract: A computer-implemented method of verifying the integrity of part of a pre-image corresponding to a hash digest generated by hashing the preimage with a SHA-based hash function, wherein the pre-image comprises a first message and a second message, and wherein the method comprises: a) receiving an iteration input vector; b) obtaining a second sequence of blocks; c) generating a final iteration output vector by performing an iteration of the SHA-based hash computation for each of the second sequence of blocks in order of a respective position in the second sequence of blocks, wherein the iteration of the SHA-based hash computation performed on a first one of the second sequence of blocks is based on the obtained iteration input vector; and d) generating a candidate hash digest based on the final iteration output vector, the candidate hash digest being for comparison with the hash digest.

Abstract: A robotic catheter procedure system includes a bedside system that has a percutaneous device, and an actuating mechanism configured to engage and to impart movement to the percutaneous device. The system also includes a workstation coupled to the bedside system. The workstation includes a user interface configured to receive a user input, ma display device configured to display an image, a control system operatively coupled to the user interface and the actuating mechanism. The control system is configured to generate a control signal and the actuating mechanism causes movement of the percutaneous device in response to the control signal. The control system is configured to slow movement of the percutaneous device via the actuating mechanism as an identified point on the percutaneous device approaches a structure requiring a change in direction of the percutaneous device.

Abstract: A sheath assembly for the insertion of a percutaneous pump includes a tubular sheath body dimensioned for insertion into a blood vessel through a vessel aperture. The tubular sheath body includes a wall having a proximal end portion, a distal end portion, a longitudinal axis, an outer surface, an inner surface defining a first lumen substantially parallel to the longitudinal axis, and a second lumen disposed within the wall between the inner surface and the outer surface and extending from the proximal end portion to the distal end portion. The first lumen is dimensioned to allow passage of a portion of the percutaneous pump, and the second lumen is dimensioned for passage of a guidewire. A stylet is removably positioned to substantially occlude the second lumen. The stylet has a proximal end releasably secured to the sheath assembly.

Abstract: The present disclosure includes kits, compositions, and methods useful in medical procedures, such as treating a fistula or other target site of a subject. In some examples, the kit may comprise a dry particulate mixture, a first pharmaceutically acceptable buffer solution having a pH ranging from about 3 to about 5, and a second pharmaceutically acceptable buffer solution having a pH ranging from about 9 to about 11. The dry particulate mixture may comprise a plurality of polyethylene glycol particles and a plurality of collagen particles.

Abstract: A hinged support apparatus that can include a mounting plate, an elongated base, and two living hinges on the elongated base. The mounting plate can have a proximal and a distal end. The elongated base can have a proximal end, a midway point, and a distal end, wherein the proximal end of the elongated base can be attached to at least a portion of the proximal end of the mounting plate and the midway point can create a proximal half and a distal half of the elongated base. A first of the two living hinges can be located between the proximal end and the midway point of the elongated base. A second of the two living hinges can be located between the first living hinge and the midway point of the elongated base. The two living hinges can be parallel to each other and can pivot in the same direction.

Abstract: A robotic catheter procedure system includes a bedside system that has a percutaneous device, and an actuating mechanism configured to engage and to impart movement to the percutaneous device. The system also includes a workstation coupled to the bedside system. The workstation includes a user interface configured to receive a user input, ma display device configured to display an image, a control system operatively coupled to the user interface and the actuating mechanism. The control system is configured to generate a control signal and the actuating mechanism causes movement of the percutaneous device in response to the control signal. The control system is configured to slow movement of the percutaneous device via the actuating mechanism as an identified point on the percutaneous device approaches a structure requiring a change in direction of the percutaneous device.

Abstract: An internet service provider (ISP) is configured to analyze a subscriber's sent e-mail packets to determine a subscriber identity associated with the e-mail packets. A database is then queried to determine a current sending rate of e-mails by the subscriber. A sending rate above an allowed threshold causes the upstream transmission of the e-mail packets to be blocked by injecting connection destroying packets. A subscriber remains blocked from upstream transmission of e-mails until the sending rate as determined by the ISP drops below a second, more stringent threshold. This automatic process is also accompanied by automated messaging to the subscriber with information as to the measures taken and remedial options.

Abstract: A system and method for altering bone growth on and within an orthopedic implant that includes an implant body; a plurality of electrodes, wherein each electrode is at least partially embedded in the implant body, and comprises: a set of primary electrodes comprising at least one electrode, wherein a non-embedded segment of each primary electrode is proximal to a bone growth region, a set of secondary electrodes comprising at least one electrode, wherein a non-embedded segment of each secondary electrode is distal to the bone growth region, and wherein the plurality of electrodes are configured to function in a stimulation operating mode, such that a subset of primary electrodes function as cathodes and a subset of secondary electrodes function as anodes; a control system comprising a processor, and circuitry that connects to the plurality of electrodes; and a power system.

Abstract: A method for providing watermark to subscribers is provided. The method comprises observing a request for a first content from a subscriber, determining if the subscriber can receive a watermark, generating a second content comprising the watermark if the subscriber can receive a watermark, causing the subscriber to fetch the first content, and causing the subscriber to fetch the second content comprising the watermark overlaying the first content.

Abstract: In a set-top-box system, messages from a service provider are stored and delayed until activity from a set-top-box remote is detected. Messages are then generated and provided to a television associated with the set-top-box. Delaying of the message display until set-top-box activity is detected allows short display times, thus preventing burn-in on some television screens, while providing a greater likelihood that messages will be viewed.

Abstract: The disclosed end-to-end product customization systems and methods receive custom orders from customers or consumers, evaluate them, and generate production-ready custom orders that are able to be used by decorator to create the custom products. The system receives a customization option and an order file type in the custom order. The system or a third party evaluates that customization option to identify a change order that is required and also determines a conversion recommendation to convert the order file type or a production-ready file type. The production-ready custom order is generated based on the change order and the conversion recommendation.

Abstract: A stimulation scheduling system includes a control signal generator and a controller, which can form a control loop configured to generate sets of consistent pulse schedules with a controlled degree of difficulty. The control signal generator can generate a set of consistent pulse schedules using a set of corresponding stimulation parameter distributions and provide a detection parameter based on the generation of the set of consistent pulse schedules to a controller. The controller can estimate a difficulty state based on the detection parameter and update the stimulation parameter distributions based on the estimated difficulty state. The controller can model the difficulty of generating sets of consistent pulse schedules using a difficulty distribution. The difficulty state can be a parameter of the difficulty distribution. The controller can balance the difficulty of generating sets of consistent pulse schedules against the fidelity of the generated sets of pulse schedules.

Abstract: Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.

Abstract: In a set-top-box system, messages from a service provider are stored and delayed until activity from a set-top-box remote is detected. Messages are then generated and provided to a television associated with the set-top-box. Delaying of the message display until set-top-box activity is detected allows short display times, thus preventing burn-in on some television screens, while providing a greater likelihood that messages will be viewed.

Abstract: A system and method for embedded electronics within a medical implant comprising: an implant body; a circuitry surface, containing at least one electronic component, wherein the circuitry surface is at least partially embedded within a defined cavity of the implant along at least one path; sheathing, comprising a protective structure, wherein the at least partially embedded portion of the circuitry surface is enclosed within the sheathing; electronic components connected to, or directly on, the circuitry surface, comprising a set of electrodes and an antenna; and wiring, connecting the circuitry surface and electronic components. The system and method may further include a casing, wherein the casing is a sealed structure directly connected to the implant body including a printed a circuit board (PCB) contained within the casing itself.

Abstract: A robotic catheter procedure system for performing a procedure to treat a vascular lesion includes a first percutaneous device extending through a lumen and out of a distal end of a second percutaneous device, the first percutaneous device comprising a helical section, a first actuating mechanism coupled to first percutaneous device and configured to engage and to impart axial and rotational movement to the first percutaneous device, and a second actuating mechanism coupled to the first percutaneous device and configured to change a diameter of the helical section of the first percutaneous device to a first diameter to create a bore of a first size through the vascular lesion.

Abstract: Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.

Abstract: A sheath assembly for the insertion of a percutaneous pump includes a tubular sheath body dimensioned for insertion into a blood vessel through a vessel aperture. The tubular sheath body includes a wall having a proximal end portion, a distal end portion, a longitudinal axis, an outer surface, an inner surface defining a first lumen substantially parallel to the longitudinal axis, and a second lumen disposed within the wall between the inner surface and the outer surface and extending from the proximal end portion to the distal end portion. The first lumen is dimensioned to allow passage of a portion of the percutaneous pump, and the second lumen is dimensioned for passage of a guidewire. A stylet is removably positioned to substantially occlude the second lumen. The stylet has a proximal end releasably secured to the sheath assembly.