Abstract: Isolate monoclonal antibodies that bind to specific epitopes of human tissue factor pathway inhibitor (TFPI) and the isolated nucleic acid molecules encoding them are provided. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided.

Abstract: In a set-top-box system, messages from a service provider are stored and delayed until activity from a set-top-box remote is detected. Messages are then generated and provided to a television associated with the set-top-box. Delaying of the message display until set-top-box activity is detected allows short display times, thus preventing burn-in on some television screens, while providing a greater likelihood that messages will be viewed.

Abstract: A watertube panel portion for a fluidized bed reactor and a corresponding method. The watertube panel portion includes multiple parallel metal tubes having a tube length L1, an outer surface, an original outer diameter OD1, and an original wall thickness WT1, and a circumferentially extending recess formed in a central portion of each of the tubes, between first and second end portions. The recess has a constant depth D that is less than the wall thickness WT1. The recess encircles the outer surface of the central portion of the metal tube. A circumferentially extending metal coating has a constant thickness of at most the depth D of the recess to blanket the recess of each of the multiple metal tubes. A fin is continuously welded between each pair of adjacent tubes.

Abstract: A system for fluidizing a fluidizable medium includes a person support structure, fluid supply, sensor, and controller. The person support structure includes a chamber containing a fluidizable medium and a plenum in fluid communication with the chamber. The fluid supply is in fluid communication with the plenum. The sensor is configured to sense a pressure of fluid in the plenum. The controller is configured to control the operation of the fluid supply as a function of the fluid pressure within the plenum to achieve a desirable level of fluidization of the fluidizable medium.

Abstract: A robotic catheter procedure system includes a bedside system and a workstation. The bedside system includes an actuating mechanism configured to engage and to impart movement to a percutaneous device. The workstation includes a user interface and a control system configured to be operatively coupled to the user interface, the bedside system, and a medical imaging system. The control system is responsive to a first input and to a second input, and the user interface receives the second input from a user. The control system is configured to generate a first control signal to the medical imaging system based on the first input, and the medical imaging system captures at least one image in response to the first control signal. The control system is configured to generate a second control signal to the actuating mechanism based on the second input, and the actuating mechanism causes movement of the percutaneous device in response to the second control signal.

Abstract: A system, method, and computer readable medium for communicating at least one real-time specially-composed bulletin message to at least one subscriber of a provider of Internet services, comprising a first device, and a second device communicably coupled to the first device, wherein the first device: accesses only subscriber upstream traffic to a destination web site requested by the subscriber, wherein the first device inter-connects between the at least one subscriber and the destination web site, identifies the at least one subscriber's identification based on the accessed subscriber upstream traffic automatically provided by the subscriber, and provides the unique subscriber identification to the second device located at the provider of Internet services providing data services and management control to the first device, wherein the second device determines the subscriber associated with the unique subscriber identification.

Abstract: A robotic catheter procedure system for performing a procedure to treat a vascular lesion including a bedside system and a remote workstation is provided. The bedside system includes a first percutaneous device including an end section, the end section structured to allow the first percutaneous device to create a bore through the vascular lesion. The bedside system includes a second percutaneous device. The bedside system also includes a first actuating mechanism configured to engage and to impart movement to the first percutaneous device and a second actuating mechanism configured to engage and to impart movement to the second percutaneous device. The remote workstation includes a user interface and a control system operatively coupled to the user interface and to the bedside system.

Abstract: A method for communicating in real-time to users of a provider of Internet access service, without requiring any installation or set-up by the user, that utilizes the unique identification information automatically provided by the user during communications for identifying the user to provide a fixed identifier which is then communicated to a redirecting device. Messages may then be selectively transmitted to the user. The system is normally transparent to the user, with no modification of its content along the path. Content then may be modified or replaced along the path to the user. For the purposes of establishing a reliable delivery of bulletin messages from providers to their users, the system forces the delivery of specially-composed World Wide Web browser pages to the user, although it is not limited to that type of data.

Abstract: An internet service provider (ISP) is configured to analyze a subscriber's sent e-mail packets to determine a subscriber identity associated with the e-mail packets. A database is then queried to determine a current sending rate of e-mails by the subscriber. A sending rate above an allowed threshold causes the upstream transmission of the e-mail packets to be blocked by injecting connection destroying packets. A subscriber remains blocked from upstream transmission of e-mails until the sending rate as determined by the ISP drops below a second, more stringent threshold. This automatic process is also accompanied by automated messaging to the subscriber with information as to the measures taken and remedial options.

Abstract: A tubular waterwall structure in a fluidized bed reaction chamber includes horizontally adjacent first and second portions forming a corner structure and constituted by vertical tubes and fins centrally attached to the tubes and having a first width. The first wall portion has an outermost tube next to the corner, an upper portion defining an upper vertical plane in an upper level range and a lower portion defining a lower (outwards) vertical plane in a lower level range. The lower portion has a refractory lining. The second wall portion is vertical and has an outermost tube next to the corner. The outermost tube of the second wall portion is in the lower level region connected to the outermost tube of the first wall portion by a planar lower beveled corner fin having a refractory lining and a width that is larger than the first width.

Abstract: Techniques for managing and routing market orders across a global trading system. Each trading node can be associated with one or more markets and each node can be configured to provide market access to each market associated with a node in the system. Each trading node can be connected, via a network, to a global switching layer. The global switching layer can route requests, such as orders and the like, from an end user associated with one of the plurality of nodes to a corresponding exchange or market. The global switching layer can be configured to dynamically provide, to each end user, a user interface element corresponding to each trading node.

Abstract: The present invention relates to methods for the design and/or production of a probe or primer that is capable of hybridizing to a plurality of sites in a sample comprising nucleic acid. Furthermore, the present invention provides methods for detecting and amplifying nucleic acid using such a probe or primer, for example, for identification of a strain, species or genera. Probe or primer sequences are determined by reference to codon usage bias of a target nucleic acid. In addition, the present invention provides methods for determining codon distribution and/or base pair distance between codons in a nucleic acid.

Abstract: A watertube panel portion for a fluidized bed reactor and a corresponding method. The watertube panel portion includes multiple parallel metal tubes having a tube length L1, an outer surface, an original outer diameter OD1, and an original wall thickness WT1, and a circumferentially extending recess formed in a central portion of each of the tubes, between first and second end portions. The recess has a constant depth D that is less than the wall thickness WT1. The recess encircles the outer surface of the central portion of the metal tube. A circumferentially extending metal coating has a constant thickness of at most the depth D of the recess to blanket the recess of each of the multiple metal tubes. A fin is continuously welded between each pair of adjacent tubes.

Abstract: This disclosure provides protease-regulated antibodies which specifically bind to tissue factor pathway inhibitor (TFPI). The antibodies are useful for treating bleeding disorders such as hemophilia.

Abstract: A robotic catheter procedure system is provided. The robotic catheter procedure system includes a bedside system and a remote workstation. The bedside system includes a percutaneous device and a drive mechanism configured to engage and to impart an axial force to the percutaneous device and to advance and retract the percutaneous device. The bedside system includes an actuator providing torque to the drive mechanism to impart the axial force to the percutaneous device, and the torque provided by the actuator is variable. The remote workstation includes a user interface configured to receive a first user input and a control system operatively coupled to the user interface. The control system is configured to communicate a control signal to the actuator. The control signal is based upon the first user input and a second input, and the actuator provides torque to the drive mechanism in response to the control signal.

Abstract: An internet service provider (ISP) is configured to analyze a subscriber's sent e-mail packets to determine a subscriber identity associated with the e-mail packets. A database is then queried to determine a current sending rate of e-mails by the subscriber. A sending rate above an allowed threshold causes the upstream transmission of the e-mail packets to be blocked by injecting connection destroying packets. A subscriber remains blocked from upstream transmission of e-mails until the sending rate as determined by the ISP drops below a second, more stringent threshold. This automatic process is also accompanied by automated messaging to the subscriber with information as to the measures taken and remedial options.

Abstract: A chiller plant including at least two chillers operating at different temperatures are disclosed. Process fluid circuits of the chillers can form fluid communication when, for example, one or more of the at least two chillers may fail, so that the other chiller(s) of the at least two chillers may provide backup operation to the failed chiller(s).

Abstract: A redirection of a URL page request may be performed by monitoring an upstream path from a subscriber to the internet through an ISP. When a URL page request is detected from a subscriber for whom a redirection is required, a redirection device generates a single TCP packet response that mimics a response from the intended destination server. The single TCP packet includes a set FIN bit that closes any active session with the destination server to prevent the subscriber from accepting packets from the destination server.

Abstract: Techniques for managing and routing market orders across a global trading system. Each trading node can be associated with one or more markets and each node can be configured to provide market access to each market associated with a node in the system. Each trading node can be connected, via a network, to a global switching layer. The global switching layer can route requests, such as orders and the like, from an end user associated with one of the plurality of nodes to a corresponding exchange or market. The global switching layer can be configured to dynamically provide, to each end user, a user interface element corresponding to each trading node.

Abstract: A watertube panel portion for a fluidized bed reactor and a corresponding method. The watertube panel portion includes multiple parallel metal tubes having a tube length L1, an outer surface, an original outer diameter OD1, and an original wall thickness WT1, and a circumferentially extending recess formed in a central portion of each of the tubes, between first and second end portions. The recess has a constant depth D that is less than the wall thickness WT1. The recess encircles the outer surface of the central portion of the metal tube. A circumferentially extending metal coating has a constant thickness of at most the depth D of the recess to blanket the recess of each of the multiple metal tubes. A fin is continuously welded between each pair of adjacent tubes.