Abstract: A medical system including a compressible device, and a covering over the compressible device, wherein the covering includes a delivery configuration and a deployed configuration, wherein, in the delivery configuration, the covering at least partially covers the compressible device to maintain the compressible device in a compressed state, and wherein, in the deployed configuration, the covering is releasable from the device to transition the compressible device from the compressed state to an expanded state.

Abstract: A valve assembly for a medical device including a container including a first region and a second region, a first fluid inlet fluidly coupled to the first region, a second fluid inlet fluidly coupled to the second region, and a piston assembly disposed within the container. The container is configured to house an agent within the second region, the first fluid inlet is configured to deliver a first portion of pressurized fluid to the first region at a first pressure level, and the second fluid inlet is configured to deliver a second portion of pressurized fluid to the second region at a second pressure level that is less than the first pressure level. The piston assembly includes a valve configured to move from a first position to a second position in response to the piston assembly moving relative to the container.

Abstract: A video game includes a single player mode where completion of storyline objectives advances the single player storyline. The video game also includes a multiplayer mode where a plurality of players can play on an instance of a multiplayer map. Storyline objectives from the single player mode are selected and made available for completion to players in the multiplayer mode, and the single player storylines can be advanced by players completing respective storyline objectives while playing in the multiplayer mode. Combinations of storyline objectives are selected from pending storyline objectives for players connecting to a multiplayer game for compatibility with multiplayer maps. Constraints can be used to determine compatibility.

Abstract: A medical device such as a stent or medical balloon is functionalised prior to coating with a bioactive material, specifically by carboxylic acidification of the contact surface or surfaces of the medical device. The preferred process involves washing a stent or other medical device in a washing solution which may be sodium hydroxide, soaking in a carboxylic acid solution, rinsing in water to remove excess carboxylic acid, allowing to dry before applying a bioactive agent layer. It has been found that washing after functionalisation removes excess carboxylic acid and enhances the retention of bioactive agent on the contact surface or surfaces of the medical device leading to a more uniform and consistent layer of bioactive agent.

Abstract: A joist assembly system that is structured for dynamic retrieval of components, dynamic and precise positioning and location of retrieved components, assembly of the components to form a joist, and delivery of the assembled joist. The joist assembly system has a plurality of material handling systems, a plurality of welding systems, and a rigging table system. The material handling systems are structured to load and position the components such as chords and webs onto the rigging table. The rigging table in turn supports the chords or webs. Subsequently, the plurality of welding systems weld the webs to the chords to form the joist.

Abstract: Systems and methods for selecting a treatment regimen for a particular patient are provided. The treatment regimen is selected using a first data store including a first plurality of patient records for a first plurality of patients, and a second data store including efficacy rates of a plurality of treatment regimens against a plurality of infections and infection-causing pathogens. The system, or a user of the system, identifies a first infection of the particular patient and a first treatment regimen to be prescribed to treat the first infection. A second plurality of patient records is generated by identifying, in the first plurality of patient records of the first data store, patient records associated with diagnosis or treatment of the first infection. The second plurality of patient records are appended with efficacy rates for the first infection from the second data store.

Abstract: An adaptive seat is run in with an isolating object to beyond a landing location for the adaptive seat. The adaptive seat is released to expand and engage the surrounding tubular. Pressure from below acts on the object and propels the object against the adaptive seat. The object and the adaptive seat move in the tubular to a nearby landing location such as a groove or recess in a sub that is part of the string or another location such as a tubular joint where the adaptive seat finds support. An upper portion of the borehole is isolated for a time from formation pressure to allow running in an ESP from the surface. The object is removed by degradation or from being structurally undermined and the ESP is operated to produce the formation. One or more removable barriers are contemplated.

Abstract: A method for attaching a prepared sample to a carrier in a focused ion beam chamber. The method includes reducing a temperature within the chamber to substantially below room temperature followed by moving the prepared sample adjacent to a substrate carrier surface. The temperature can be lowered sufficiently to establish a cryogenic condition in the chamber. Attachment of the prepared sample to the substrate carrier is done by controlling the focused ion beam to raster a target area of the surface in the absence of a gas deposition precursor, to sputter material onto the base of the sample and the substrate carrier surface, thereby binding the prepared sample to the substrate carrier.

Abstract: An adaptive seat is run in with an isolating object to beyond a landing location for the adaptive seat. The adaptive seat is released to expand and engage the surrounding tubular. Pressure from below acts on the object and propels the object against the adaptive seat. The object and the adaptive seat move in the tubular to a nearby landing location such as a groove or recess in a sub that is part of the string or another location such as a tubular joint where the adaptive seat finds support. An upper portion of the borehole is isolated for a time from formation pressure to allow running in an ESP from the surface. The object is removed by degradation or from being structurally undermined and the ESP is operated to produce the formation. One or more removable barriers are contemplated.

Abstract: Systems and methods for selecting a treatment regimen for a particular patient are provided. The treatment regimen is selected using a first data store including a first plurality of patient records for a first plurality of patients, and a second data store including efficacy rates of a plurality of treatment regimens against a plurality of infections and infection-causing pathogens. The system, or a user of the system, identifies a first infection of the particular patient and a first treatment regimen to be prescribed to treat the first infection. A second plurality of patient records is generated by identifying, in the first plurality of patient records of the first data store, patient records associated with diagnosis or treatment of the first infection. The second plurality of patient records are appended with efficacy rates for the first infection from the second data store.

Abstract: The invention provides methods of screening for capsid-encoding nucleotide sequences of adeno-associated virus (“AAV”) particles capable of infecting a subject's neurons, or sub-compartments thereof, involving neurons derived from induced pluripotent stem cells or embryonic stem cells. The invention also provides AAV capsids, capsid-encoding nucleotide sequences, expression vectors, viral particles, cells and kits for use in methods of treating neuromuscular or neuromotor disorders, such as spasticity. Sequences generated from the methods may lead to new gene therapies targeted to select populations of neurons, such as motor neurons innervating muscle cells, thus providing high specificity that may be personalised to the subject.

Abstract: An intelligent agent monitors operation of at least one software virtualized network (VN). Context information associated with the VN is used to analyze a state of the VN. At least one configuration change is caused to the VN in response to analysis of the state of the VN. A change is identified to the state of the VN caused by the configuration change. A determination is made as to whether or not the change to the state of the VN is an improvement to operation of the VN. A response to the determination is made by causing at least one other configuration change to the VN.

Abstract: A process for preparing a compound of formula (II): includes reacting a compound of formula (VIII): with a compound of formula (XIV):

Abstract: A system may allow for generic end user mobile devices to be operated using a virtualized personal device framework. The virtualized personal device framework may provide for a collective intelligence network platform that allows offloading of heavy computing processes onto virtual instance in a cloud network and enables crowd sourcing services for smart cities that may provide smart emergency services in which end-users collaborate.

Abstract: A carrier grid with integrated gas delivery system for use in a charged particle beam system (CPB). The carrier grid has a body with an internal reservoir for storing a gas. A post extends from the body with an end for supporting a sample to be operated upon, and an outlet tip extends from the end of the post. A channel extends from the reservoir, through the post and ends in the outlet tip, where the outlet tip seals the stored gas in the body. Cutting the outlet tip near its base, with a focused ion beam (FIB) by example, will open the channel to the CPB chamber, allowing the prestored gas within the reservoir to escape. A FIB or electron beam directed at the junction of the sample positioned near the post will cause deposition and subsequent attachment of the sample to the post in presence of the gas.

Abstract: Introduced here are approaches to simulating the actions of, and interactions between, biological systems in target environments through the use of computational workflows. These actions may relate to natural processes and novel adaptations (e.g., introduced through genetic engineering). At a high level, the computational workflows described herein provide a framework for efficient data management, thereby allowing increased productivity. While simplified approaches to user input are one feature highlighted in the present disclosure, the computational workflows described herein may also allow modification of parameters for any or all software modules in the workflow.

Abstract: An intelligent agent monitors operation of at least one software virtualized network (VN). Context information associated with the VN is used to analyze a state of the VN. At least one configuration change is caused to the VN in response to analysis of the state of the VN. A change is identified to the state of the VN caused by the configuration change. A determination is made as to whether or not the change to the state of the VN is an improvement to operation of the VN. A response to the determination is made by causing at least one other configuration change to the VN.

Abstract: A process for preparing a compound of formula (II): includes reacting a compound of formula (VIII): with a compound of formula (XIV):

Abstract: An imaging device (010, 10, 110) comprises a first optical system (020, 20, 120) at a distal end of the imaging device, a second optical system (080, 80, 180) towards the proximal end of the imaging device, and a sensor (074, 74, 174) at the proximal end of the imaging device. The first and second optical systems and the sensor are aligned along a common longitudinal axis. The first optical system is or comprises one or more reflective and/or refractive optical components (24, 124; 22, 122) symmetrically and/or coaxially arranged with respect to the longitudinal axis, and the second optical system comprises one or more reflective and/or refractive optical components (24, 124; 22, 122) for focussing incident light towards the sensor. A calibration system (200) and method for calibrating such an imaging device, and a method of processing image data obtained from such an imaging device are also provided.

Abstract: Aspects of the subject disclosure may include, for example, a process or apparatus for receiving, by a processing system including a processor, cell traffic reports for cells of a radio communication network, performing a reconfiguration analysis to identify reconfiguration information to reconfigure the radio communication network according to changing network conditions, and communicating the reconfiguration information defining a new cell configuration for the cells of the radio communication network and communicating information defining a new reconfiguration time for the cells to substantially synchronously switch to communicating according to the reconfiguration information. The receiving the cell traffic reports, the performing the reconfiguration analysis and the communicating the reconfiguration information occur in substantially real time. Other embodiments are disclosed.