Patents by Inventor John A. Oates

John A. Oates has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS FOR SCAVENGING DICARBONYL ELECTROPHILES
    Publication number: 20240000726
    Abstract: Compounds and methods of scavenging bifunctional electrophiles and reducing the occurrence of lysyl-levuglandin adducts in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein.
    Type: Application
    Filed: July 10, 2023
    Publication date: January 4, 2024
    Inventors: Keith T. Wilson, John A. Oates, Olivier Boutaud, Venkataraman Amarnath, Erica J. Carrier, Alain P. Gobert
  • Compounds and methods for scavenging dicarbonyl electrophiles
    Patent number: 11696903
    Abstract: Compounds and methods of scavenging bifunctional electrophiles and reducing the occurrence of lysyl-levuglandin adducts in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein.
    Type: Grant
    Filed: June 4, 2020
    Date of Patent: July 11, 2023
    Assignees: Vanderbilt University, The United States as Represented by the Department of Veterans Affairs
    Inventors: Keith T. Wilson, John A. Oates, Olivier Boutaud, Venkataraman Amarnath, Erica J. Carrier, Alain P. Gobert
  • Methods of preventing platelet activation
    Patent number: 11400103
    Abstract: A method of preventing or reducing the occurrence of malondiadehyde and/or levuglandin protein modification in a subject in need thereof, comprising administering to said subject an effective amount of at least one reactive dicarbonyl scavenger compound, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: August 2, 2022
    Assignee: Vanderbilt University
    Inventors: John A. Oates, Olivier Boutaud, Irene Zagol-Ikapitte
  • Methods for treating atherosclerosis with gamma-ketoaldehyde scavengers
    Patent number: 11389414
    Abstract: A method of treating atherosclerosis, comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: July 19, 2022
    Assignee: Vanderbilt University
    Inventors: Macrae F. Linton, John A. Oates, Sean S. Davies, L. Jackson Roberts, II, Venkataraman Amarnath, Patricia G. Yancey, Huan Tao
  • COMPOUNDS AND METHODS FOR SCAVENGING DICARBONYL ELECTROPHILES
    Publication number: 20200383938
    Abstract: Compounds and methods of scavenging bifunctional electrophiles and reducing the occurrence of lysyl-levuglandin adducts in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein.
    Type: Application
    Filed: June 4, 2020
    Publication date: December 10, 2020
    Inventors: Keith T. Wilson, John A. Oates, Olivier Boutaud, Venkataraman Amarnath, Erica J. Carrier, Alain P. Gobert
  • METHODS OF PREVENTING PLATELET ACTIVATION
    Publication number: 20200246358
    Abstract: A method of preventing or reducing the occurrence of malondiadehyde and/or levuglandin protein modification in a subject in need thereof, comprising administering to said subject an effective amount of at least one reactive dicarbonyl scavenger compound, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 17, 2020
    Publication date: August 6, 2020
    Inventors: John A. Oates, Olivier Boutaud, Irene Zagol-Ikapitte
  • Methods of preventing platelet activation
    Patent number: 10688109
    Abstract: A method of preventing or reducing the occurrence of malondiadehyde and/or levuglandin protein modification in a subject in need thereof, comprising administering to said subject an effective amount of at least one ?-KA scavenger compound, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: June 23, 2020
    Assignee: Vanderbilt University
    Inventors: John A. Oates, Olivier Boutaud, Irene Zagol-Ikapitte
  • Inhibitors of hemeprotein-catalyzed lipid peroxidation
    Patent number: 10675285
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: June 9, 2020
    Assignee: Vanderbilt University
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • METHODS FOR TREATING ATHEROSCLEROSIS WITH GAMMA-KETOALDEHYDE SCAVENGERS
    Publication number: 20200138747
    Abstract: A method of treating atherosclerosis, comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Application
    Filed: April 27, 2018
    Publication date: May 7, 2020
    Inventors: MacRae F. Linton, John A. Oates, Sean S. Davies, L. Jackson Roberts, II, Venkataraman Amarnath, Patricia G. Yancey, Huan Tao
  • Methods of preventing platelet activation
    Patent number: 10166248
    Abstract: A method of preventing or reducing the occurrence of malondiadehyde and/or levuglandin protein modification in a subject in need thereof, comprising administering to said subject an effective amount of at least one ?-KA scavenger compound, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: January 1, 2019
    Assignee: Vanderbilt University
    Inventors: John A. Oates, Olivier Boutaud, Irene Zagol-Ikapitte
  • Inhibitors of hemeprotein-catalyzed lipid peroxidation
    Patent number: 9545385
    Abstract: Compounds, compositions and methods related to the prevention or treatment of isoprostane-mediated tissue damage in a mammalian subject in need thereof.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: January 17, 2017
    Assignee: Vanderbilt University
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • Inhibitors of Hemeprotein-Catalyzed Lipid Peroxidation
    Publication number: 20160067256
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Application
    Filed: September 15, 2015
    Publication date: March 10, 2016
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • INHIBITORS OF HEMEPROTEIN-CATALYZED LIPID PEROXIDATION
    Publication number: 20150368241
    Abstract: Compounds, compositions and methods related to the prevention or treatment of isoprostane-mediated tissue damage in a mammalian subject in need thereof.
    Type: Application
    Filed: February 5, 2014
    Publication date: December 24, 2015
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter
  • LEVUGLANDIN ADDUCTS HISTONE H4 IN A CYCLOOXYGENASE-2-DEPENDENT MANNER, ALTERING ITS INTERACTION WITH DNA
    Publication number: 20150265584
    Abstract: Method of inhibiting formation of levuglandin adducts of histone and DNA in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein.
    Type: Application
    Filed: March 18, 2015
    Publication date: September 24, 2015
    Inventors: John A. Oates, Olivier Boutaud, Venkataraman Amarnath, Erica J. Carrier
  • Inhibitors of hemeprotein-catalyzed lipid peroxidation
    Patent number: 9133212
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: September 15, 2015
    Assignee: Vanderbilt University
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • Inhibitors of hemeprotein-catalyzed lipid peroxidation
    Patent number: 8367669
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: February 5, 2013
    Assignee: Vanderbilt University
    Inventors: John A. Oates, L. Jackson Roberts, II, Ned A. Porter, Olivier Boutaud
  • INHIBITORS OF HEMEPROTEIN-CATALYZED LIPID PEROXIDATION
    Publication number: 20080227776
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Application
    Filed: March 26, 2008
    Publication date: September 18, 2008
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud