Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: This disclosure describes a system, method, and non-transitory computer readable media for an ultrasound probe configured to capture ultrasound images of an examination region. The system includes a first set of one or more sensors coupled to the ultrasound probe and configured to estimate a first positional information associated with the ultrasound probe. The system includes a second set of one or more sensors coupled to the ultrasound probe and configured to capture electromagnetic force (EMF) measurements in the examination region to estimate a second positional information associated with the ultrasound probe. The second positional information is used to calibrate the first set of one or more sensors. The system includes a controller configured to use at least one of (i) the first positional information, or (ii) the second positional information to generate a reconstruction of the examination region based on ultrasound images captured by the ultrasound probe.

Abstract: A method and system for the continuous monitoring of animal physiology in laboratory animal cages through the use of miniaturized sensors located throughout the cage and in various fashions including the ability to identify each rodent's digital sensory signature through data fusion and artificial intelligence.

Abstract: The present disclosure provides a storage system comprising a storage tank configured to store fuel at a cryogenic temperature for a predetermined amount of time. The storage tank may have a plurality of layers comprising: a first layer comprising a pressure vessel for containing the fuel at a pressurized state; a second layer comprising insulation for the first layer; a third layer comprising a vapor barrier; and a fourth layer comprising a shell configured to maintain a rigidity of the storage tank.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: An electrosurgical device comprises an electrically conductive elongate member for traversing body vasculature defining a hollow lumen with one or more apertures at or near its distal end, wherein electrical energy can flow through the wall of the elongate member; and an energy delivery device in electrical communication with the elongate member is located distal to the end of the elongate member. The energy delivery device includes an electrode for delivering energy. Methods of using the electrosurgical device include cutting through occlusions and creating transseptal punctures.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: A robotic cleaner includes a housing, a suction conduit with an opening, and a leading roller mounted in front of a brush roll. An inter-roller air passageway may be defined between the leading roller and the brush roll wherein the lower portion of the leading roller is exposed to a flow path to the suction conduit and an upper portion of the leading roller is outside of the flow path. Optionally, a combing unit includes a plurality of combing protrusions extending into the leading roller and having leading edges not aligned with a center of the leading roller. Optionally, a sealing strip is located along a rear side of the opening and along a portion of left and right sides of the opening. The underside may define side edge vacuum passageways extending from the sides of the housing partially between the leading roller and the sealing strip towards the opening.

Abstract: A method and apparatus are disclosed for providing forward fluid delivery through an electrosurgical device, while avoiding coring when energy is delivered to the electrosurgical device. The device has a distal face defining an opening, with the distal face including at least one cutting portion and at least one non-cutting portion. An embodiment of the electrosurgical device for puncturing tissue includes an elongate member defining a lumen for fluid; a distal portion including an electrode and the distal face which defines at least one aperture. The portion of the at least one cutting portion defines a leading portion partially surrounding a circumference of the at least one aperture wherein the outer diameter of the at least one of the distal portion of the electrosurgical device or the electrode decreases towards a distal tip of the electrosurgical device.

Abstract: The present disclosure generally relates to a method for preparing a powder or granular foam control compositions and methods for reducing or preventing or breaking foam in various applications such as powder detergents as well as coatings, cementing, concrete, gypsum board and other construction type applications or in some agricultural formulations like fertilizers, herbicides and pesticides.

Abstract: Provided in this disclosure is a battery pack system including battery modules each including battery cells. An air-tight, sealed enclosure retains the battery modules. A battery manager controls operation of each of the battery modules. One or more thermal runaway shield (TRS) pouches are associated with each of the battery modules. The TRS pouches include a thermally cooling fluid that ruptures into the battery module from heat produced in a thermal runaway event in the battery module. A pressure monitoring sensor detects an increase in air pressure within the sealed enclosure associated with gas released from the thermal runaway event in the battery cells in the battery modules. A communication component transmits a pressure signal from the pressure monitoring sensor to the battery manager for implementing a subsequent management step of the battery pack system.

Abstract: Provided in this disclosure is a passive internal cooling system for a battery pack. First and second stacking frames are provided, each having mating structures for engaging and retaining the first and second stacking frames to each other. Each of the first and second stacking frames are configured for substantially surrounding and enclosing a surface of a battery module for retaining one or more batteries. One or more TRS pouches are enclosed between the first and second stacking frames. The TRS pouch(es) includes a thermally cooling fluid that ruptures into the battery module from heat produced in a thermal runaway event in the battery module.

Abstract: Disclosed herein are methods, systems and GUIs for providing situational awareness about emergency incidents to emergency service providers (ESPs), for example, between different Public Safety Answering Points. In particular, the use of data indicators, notifications and banners can be used to provide a GUI rich in situational awareness for efficient emergency response.

Abstract: A method of performing speech recognition, comprises, at a first device: receiving an audio signal representing speech; performing a first data integrity check operation on the received audio signal; performing a speaker recognition process on the received audio signal; forwarding the received audio signal to a second device, wherein the second device comprises a speech recognition function; and forwarding an output of the first data integrity check operation to the second device.

Abstract: A vehicle is provided that includes a vehicle body defining a cabin interior and comprising a front row of seats and a rear row of seats, a plurality of seats located within the cabin interior, and a monitoring system for detecting and monitoring a pet or passenger within the cabin interior. The vehicle also includes a movable center console positioned between a pair of the forward row of seats and forward of the rear row of seats and comprising a holder for holding a drink container, and a controller processing signals generated by the monitoring system and determining a location of the detected pet or passenger on the rear row of seats based on the processed signals, the controller further controlling the movable console between a forward first position and a rearward second position closer to the rear row of seats.

Abstract: A method for use in a biometric process, comprising: for a first function and a second function, applying an acoustic stimulus to a user's ear; and for the second function: receiving a response signal of a user's ear to the acoustic stimulus; and extracting, from the response signal, one or more features for use in a biometric process, wherein the first function is a function other than to induce the response signal for use in the biometric process.

Abstract: Apparatuses and methods for creating phobic and philic surfaces (for example, superphobic and superphilic surfaces) are disclosed. Embodiments include methods for determining a heat treatment technique that increases the likelihood that a uniformly etched surface with minimal pitting will be formed when the surface of a material is subject to etching. Additional embodiments include evaluating the PRE number of the material, performing an anodic polarization sweep of the material, evaluating the polarization curve (current vs. potential) for the material, performing different etching protocols depending on the range of values the PRE number of the material belongs, and/or pulsing the current applied to the material during the etching process. Additional embodiments include apparatuses and methods for predictably etching a surface (such as a surface of a metal alloy) of a material, which can include etching interior portions of a hollow work piece.

Abstract: The present disclosure relates to a cartridge for an aerosol delivery device such as a smoking article. The cartridge may include a base, a reservoir substrate, and an atomizer. The reservoir substrate may define a cavity therethrough. The atomizer may comprise a liquid transport element and a heating element extending at least partially about the liquid transport element. The atomizer may extend through the cavity through the reservoir substrate such that the heating element is positioned proximate an end of the reservoir substrate. Ends of the liquid transport element may extend to an opposing end of the reservoir substrate. A related method for assembling a cartridge for a smoking article is also provided.

Abstract: The method includes receiving raw data at a cloud service relating to a hydraulic fracturing operation. The raw data can be streamed to the cloud service. The method further includes pre-processing the raw data to generate pre-processed data. The pre-processed data can be ingestible by a cloud-based dashboard. Additionally, the method includes identifying at least one parameter relating to the hydraulic fracturing operation using the pre-processed data. The method can further include determining a difference between the at least one parameter and at least one optimized parameter. Further, the method can include adjusting the hydraulic fracturing operation based the difference between the at least one parameter and the at least one optimized parameter.