Publication number: 20040005557
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
January 16, 2002
Publication date:
January 8, 2004
Inventors:
Muralidhara Padigaru, John P. Alsobrook, Steven D. Colman, Kimberly A. Spytek, Ferenc L. Boldog, Corine A.M. Vernet, Li Li, Suresh G. Shenoy, Stacie J. Casman, Xiaojia (Sasha) Guo, Shlomit R. Edinger, John R. MacDougall, Uriel M. Malyankar, Meera Patturajan, Richard A. Shimkets, Carol E. A. Pena, Velizar T. Tchernev, Bryan D. Zerhusen, Isabelle Millet, Charles E. Miller, Denise M. Lepley, Glennda Smithson, Jason C. Baumgartner, John L. Herrmann, John A. Peyman, Linda Gorman, Peter D. Mezes, Ramesh Kekuda, Raymond J. Taupier, Valerie Gerlach, William M. Grosse, Xiaohong Liu, Karen Ellerman, Mark Rothenberg, David J. Stone, Catherine E. Burgess
Publication number: 20040005656
Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
October 16, 2001
Publication date:
January 8, 2004
Inventors:
Ramesh Kekuda, Kimberly A. Spytek, Stacie J. Casman, Bryan D. Zerhusen, Li Li, Velizar T. Tchernev, Steven D. Colman, Robert A. Ballinger, Muralidhara Padigaru, Adam R. Wolenc, Suresh G. Shenoy, Shlomit R. Edinger, Valerie Gerlach, Esha A. Gangolli, John R. MacDougall, Glennda Smithson, John A. Peyman, David J. Stone, Erik Gunther, Karen Ellerman, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Catherine E. Burgess
Publication number: 20030232347
Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
August 1, 2002
Publication date:
December 18, 2003
Inventors:
David W. Anderson, John P. Alsobrook, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Shlomit R. Edinger, Esha A. Gangolli, Linda Gorman, Xiaojia Sasha Guo, Nikolai V. Khramtsov, Denise M. Lepley, John R. MacDougall, Carol E. A. Pena, John A. Peyman, Meera Patturajan, Daniel K. Rieger, Richard A. Shimkets, Glennda Smithson, Kimberly A. Spytek, Corine A.M. Vernet, Edward Z. Voss, Mei Zhong
Publication number: 20030232332
Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
December 18, 2001
Publication date:
December 18, 2003
Inventors:
Muralidhara Padigaru, Ramesh Kekuda, Li Li, Robert A. Ballinger, Stacie J. Casman, Kimberly A. Spytek, Steven D. Colman, Corine A.M. Vernet, Suresh G. Shenoy, Vladimir Y. Gusev, Uriel M. Malyankar, Shlomit R. Edinger, Valerie Gerlach, Glennda Smithson, David J. Stone, Paul Sciore, John R. MacDougall, Erik Gunther, John A. Peyman, Karen Ellerman, Isabelle Millet, Velizar T. Tchernev, David W. Anderson, Adam R. Wolenc
Publication number: 20030224982
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
July 2, 2002
Publication date:
December 4, 2003
Inventors:
Li Li, Suresh G. Shenoy, Meera Patturajan, Karen Ellerman, Linda Gorman, Mei Zhong, Elina Catterton, Kimberly A. Spytek, Charles E. Miller, Shlomit R. Edinger, Tord Hjalt, Valerie Gerlach, Richard A. Shimkets, Raymond J. Taupier, David W. Anderson, Xiaojia (Sasha) Guo, Jason C. Baumgartner, Muralidhara Padigaru, John A. Peyman, Glennda Smithson, Stacie J. Casman, Edward Z. Voss, Ferenc L. Boldog, Carol E. A. Pena, Andrei Chapoval, Luca Rastelli, Ramesh Kekuda, Corine A.M. Vernet
Publication number: 20030215449
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
March 15, 2002
Publication date:
November 20, 2003
Inventors:
Peter D. Mezes, Luca Rastelli, John L. Herrmann, John R. MacDougall, Haihong Zhong, Stacie J. Casman, Ferenc L. Boldog, Richard A. Shimkets, Linda Gorman, Andrew J. Eisen, Steven K. Spaderna, Corine A.M. Vernet, Constance Berghs, Kimberly A. Spytek, Vincent A. DiPippo, Bryan D. Zerhusen, John A. Peyman, Karen Ellerman, David J. Stone, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Daniel K. Rieger, Catherine E. Burgess, Shlomit R. Edinger, Edward Z. Voss, Charles E. Miller
Publication number: 20030212256
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
October 16, 2001
Publication date:
November 13, 2003
Inventors:
Shlomit R. Edinger, Valerie Gerlach, John R. MacDougall, Uriel M. Malyankar, Glennda Smithson, Isabelle Millet, John A. Peyman, David J. Stone, Erik Gunther, Karen Ellerman, Richard A. Shimkets, Muralidhara Padigaru, Xiaojia Guo, Meera Patturajan, Raymond J. Taupier, Catherine E. Burgess, Bryan D. Zerhusen, Ramesh Kekuda, Kimberly A. Spytek, Esha A. Gangolli, Elma R. Fernandes, Linda Gorman
Publication number: 20030198955
Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
December 19, 2001
Publication date:
October 23, 2003
Inventors:
Li Li, Muralidhara Padigaru, Robert A. Ballinger, Ramesh Kekuda, Steven D. Colman, Kimberly A. Spytek, Stacie J. Casman, Shlomit R. Edinger, Valerie Gerlach, Paul Sciore, Glennda Smithson, John A. Peyman, John R. MacDougall, David J. Stone, Corine A.M. Vernet, Suresh G. Shenoy, Erik Gunther, Isabelle Millet, Velizar T. Tchernev, David W. Anderson, Vladimir Y. Gusev, Uriel M. Malyankar, Haihong Zhong, Karen Ellerman, Adam R. Wolenc
Publication number: 20030185815
Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.
Type:
Application
Filed:
April 2, 2002
Publication date:
October 2, 2003
Inventors:
Muralidhara Padigaru, Suresh G. Shenoy, Ramesh Kekuda, Luca Rastelli, Peter D. Mezes, Glennda Smithson, Xiaojia Guo, Valerie Gerlach, Stacie J. Casman, Ferenc L. Boldog, Li Li, Bryan D. Zerhusen, Velizar T. Tchernev, Esha A. Gangolli, Corine A. M. Vernet, Kimberly A. Spytek, Uriel M. Malyankar, Meera Patturajan, Charles E. Miller, Raymond J. Taupier, Melvyn P. Heyes, Jingfang Ju, John A. Peyman, Elina Catterton, John R. MacDougall, Shlomit R. Edinger, David J. Stone, Ann Mazur
Publication number: 20030176385
Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of H-Ras, WNT-7B, acetylglucosaminyltransferase, voltage-gated K channel, IL-8, ion transport, Map3K8 and Thymidine kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding H-Ras, WNT-7B, acetylglucosaminyltransferase, voltage-gated K channel, IL-8, ion transport, Map3K8 and Thymidine kinase. Methods of using these compounds for modulation of H-Ras, WNT-7B, acetylglucosaminyltransferase, voltage-gated K channel, IL-8, ion transport, Map3K8 and Thymidine kinase.expression and for treatment of diseases associated with expression of H-Ras, WNT-7B, acetylglucosaminyltransferase, voltage-gated K channel, 1L-8, ion transport, Map3KS and Thymidine kinase are provided.
Type:
Application
Filed:
November 27, 2002
Publication date:
September 18, 2003
Inventors:
Jingfang Ju, Chunli Huang, Haihong Zhong, Jan Fredrik Simons, Bruce E. Taillon, John S. Chant, John A. Peyman, Glennda Smithson, Isabelle Millet
Publication number: 20030170838
Abstract: Disclosed herein are nucleic acid sequences that encode Wnt, zinc transporter, mitsugumin29, slit-3, LRR/GPCR, major histocompatability complex enhancer protein MAD3, interleukin 9, 5-hydroxytryptamine receptor, and thioredoxin related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Type:
Application
Filed:
September 17, 2001
Publication date:
September 11, 2003
Inventors:
Vishnu S. Mishra, Kimberly Ann Spytek, Raymond J. Taupier, Corine A. Vernet, Steven D. Colman, Linda Gorman, Velizar T. Tchernev, Uriel M. Malyankar, Suresh Shenoy, Muralidhara Padigaru, Valerie L. Gerlach, John R. MacDougall, Glennda Smithson, Isabelle Millet, John Peyman, David Stone, Erik Gunther, Karen Ellerman, Li Li, Luca Rastelli, Bryan Zerhusen