Abstract: A bidirectional electroosmotic pump may be provided. The bidirectional electroosmotic pump may be made of materials that are biocompatible and non-ferrous. The bidirectional electroosmotic pump may be part of an implantable medical device for the purpose of medicine delivery. The bidirectional electroosmotic pump may contain a working fluid and may facilitate the delivery of a separate payload fluid. In an exemplary embodiment, the bidirectional pump may contain bellows which may allow the pump to deliver the payload fluid through a series of valves and/or catheters. In another embodiment the bidirectional electroosmotic pump may contain a pump sensing mechanism to monitor the state of the pump.

Abstract: A method for testing advertising, said method comprising the steps of: recruiting prospective survey respondents within a single online platform and collecting inputs from the respondents representing a prospective advertising audience regarding their advertising creative variant preferences and desirability as customers, combining the individual inputs from the survey respondents to compute at least one score for each pairing of audience and creative; and recommending actions based on the computed score, wherein the recommended actions include at least one of activating pairings with high preference scores and density of desirable customers; suppressing pairings with low preference scores or low density of desirable customers; or conducting another test after changing at least one of the audience or advertising creative variants, wherein the recommended actions are within the single on-line platform.

Abstract: Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload promotes the expression or activity of a functional dystrophin protein. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide, e.g., an oligonucleotide that causes exon skipping in a mRNA expressed from a mutant DMD allele.

Abstract: Aspects of the disclosure relate to oligonucleotides designed to target DUX4 RNAs and targeting complexes for delivering the oligonucleotides to cells (e.g., muscle cells) and uses thereof, particularly uses relating to treatment of disease (e.g., FSHD). Wherein a complex comprises an anti-transferrin receptor 1 (TfR1) antibody covalently linked to an oligonucleotide configured for reducing expression or activity of DUX4.

Abstract: Aspects of the disclosure relate to methods of promoting expression or activity of a dystrophin protein and/or methods of treating DMD in a subject. In some embodiments, the methods comprise administering to the subject a composition comprising complexes (e.g., muscle targeting complexes) comprising a phosphorodiamidate morpholino oligomer (e.g., useful for targeting DMD) covalently linked to an antibody (e.g., anti-TfR1 antibody).

Abstract: A phase change material heat sink including: a carbon graphite matrix having one or more removed portions; and an expanded graphite located within the one or more removed portions.

Abstract: One aspect of the present application relates to a storage stable pharmaceutical composition comprising a sulfated glycosaminoglycan having an average molecular weight ranging from 3,000 to 15,000 Daltons, and a pharmaceutical carrier, where the pharmaceutical carrier is mixed with the sulfated glycosaminoglycan, as well as this composition's use in a method of treating a subject for a medically observable improvement. Another aspect of the present application relates to a process for producing a storage stable purified sulfated glycosaminoglycan.

Abstract: One aspect of the present application relates to a storage stable pharmaceutical composition comprising a sulfated glycosaminoglycan having an average molecular weight ranging from 3,000 to 15,000 Daltons, and a pharmaceutical carrier, where the pharmaceutical carrier is mixed with the sulfated glycosaminoglycan, as well as this composition's use in a method of treating a subject for a medically observable improvement. Another aspect of the present application relates to a process for producing a storage stable purified sulfated glycosaminoglycan.

Abstract: One aspect of the present application relates to a storage stable pharmaceutical composition comprising a sulfated glycosaminoglycan having an average molecular weight ranging from 3,000 to 15,000 Daltons, and a pharmaceutical carrier, where the pharmaceutical carrier is mixed with the sulfated glycosaminoglycan, as well as this composition's use in a method of treating a subject for a medically observable improvement. Another aspect of the present application relates to a process for producing a storage stable purified sulfated glycosaminoglycan.

Abstract: A control system in an atmospheric suit includes a broadcast-type controller area network (CAN) bus and a plurality of motor controllers coupled to the CAN bus. Each of the plurality of motor controllers has a same software design and performs a different control operation based on an assigned hardware address. The control system also includes one or more sensors to sense one or more parameter values in the atmospheric suit and to provide the one or more parameter values on the CAN bus. A primary controller communicates with the plurality of motor controllers via the CAN bus and provides communication to a wearer of the atmospheric suit or communication outside the atmospheric suit outside the CAN bus.

Abstract: Aspects of the present disclosure include methods, systems and non-transitory computer readable storage mediums for automatically generating reports based on, e.g., flow cytometric data. Methods of for automatically generating reports according to certain embodiments include: generating, based on input from a user, a report template, selecting, based on input from the user, a source group and an iterator type, wherein the source group comprises a plurality of data sets, and the iterator type corresponds to a type of data present in the source group, and iteratively populating a plurality of batch reports using the plurality of data sets of the source group, based on the iterator type, wherein each batch report conforms to the report template and is populated with a separate data set of the plurality of data sets of the source group.

Abstract: One aspect of the present application relates to a pharmaceutical composition comprising a sulfated glycosaminoglycan having an average molecular weight ranging from 3,000 to 15,000 Daltons, a skin penetrating agent, where the skin penetrating agent promotes transdermal penetration of the sulfated glycosaminoglycan when applied to intact skin surfaces, and a pharmaceutical carrier for topical application, where the pharmaceutical carrier is mixed with the sulfated glycosaminoglycan and the skin penetrating agent. This composition is useful in carrying out a method of treating a subject for pain, joint stiffness, soft tissue injury, connective tissue disorders, and/or muscle soreness.

Abstract: Nucleic acids encoding C1 inhibitor are described. Also described are expression cassettes, vectors, cells, and cell lines containing the nucleic acids, as well as methods of using the nucleic acids to treat complement-mediated disorders, such as hereditary angioedema.

Abstract: A system that determines the items on a shelf by projecting camera images to a surface aligned with the tops of the items. Projecting the images to the top surface removes distortions due to camera projections and aligns multiple images to a common reference frame. Item tops may be visible without occlusion in one or more camera images, simplifying item identification. The projected images may be input into an item detector that is trained to recognize images of the tops of items. The item detector may process projected images from different cameras with parallel feature extractor subnetworks that generate feature maps; the feature maps may then be averaged across images and the averaged feature map may be input into an item detection subnetwork.

Abstract: A system that analyzes images of a shelf to determine the available shelf space. Camera images of the shelf from multiple viewpoints may be projected onto the shelf surface to remove distortions from camera projections and to align images to a common shelf reference frame. A mask may be calculated from each projected image that identifies regions that match the appearance of the shelf surface. The shelf surface may have a specific pattern to facilitate identification of these regions. A combined mask may be formed as a union of the masks from individual projected image masks. The available shelf space corresponds to the regions in the combined mask. Combining image masks from multiple viewpoints reduces the effect of occlusion of the shelf surface by items on the shelf.

Abstract: Aspects of the present disclosure include methods for processing cytometer data, such as for group-wise analysis of the cytometer data (e.g., flow cytometry data in FCS format, mass cytometry data, genomic cytometry data). Methods according to certain embodiments include generating a compound population of events that include data accessors from cytometry data, such as where the compound population of cytometer data is from two or more different samples retained as separate raw data files (e.g., are not concatenated to form a single combined data file). Systems having an input module for receiving cytometer data and processor with memory having instructions for practicing the subject methods are also described. Non-transitory computer readable storage medium is also provided.

Abstract: System that facilitates rapid onboarding of an autonomous (cashier-less) store by capturing images of the store's items from multiple angles, with varying background colors, and that builds a classifier training dataset from these images. Background surfaces may for example be coated with retroreflective tape or film, and variable-color incident light sources may generate the desired background colors. Embodiments may automatically rotate or otherwise reorient the item placed in the onboarding system, so that a relatively small number of cameras can capture views from multiple angles. When an item is placed in the system, a fully automated process may generate a sequence of item orientations and background colors, and may capture and process images from the cameras to create training images. Images of the item from multiple angles, under varying lighting conditions, may be captured without requiring an operator to move or reorient the item.

Abstract: A phase change material heat sink including: a carbon graphite matrix having one or more removed portions; and an expanded graphite located within the one or more removed portions.

Abstract: A monolithic open cell structure apparatus including an open cell structure housing including a first side, a second side opposite the first side, a first opening located at the first side, and a second opening located opposite the first opening at a second side. The monolithic open cell structure apparatus also including a filtration portion extending from the first side to the second side within the open cell structure housing. The monolithic open cell structure apparatus further including a retaining partition that at least partially encloses the filtration portion within the open cell structure housing. The monolithic open cell structure apparatus is a single piece including a unitary structure.