Patents by Inventor John A. Ray

John A. Ray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8673948
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: March 18, 2014
    Assignee: GlaxoSmithKline, LLC
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, Andrew Larkin, Huiquiang Zhou, Eugene L. Stewart, Katherine Stetson, Darryl Lynn McDougald, Amarjit Sab Randhawa, John A. Ray
  • Publication number: 20110301203
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Application
    Filed: August 19, 2011
    Publication date: December 8, 2011
    Applicant: GLAXOSMITHKLINE LLC
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, Andrew Larkin, Huiquiang Zhou, Eugene L. Stewart, Katherine Stetson, Darryl Lynn McDougald, Amarjit Sab Randhawa, John A. Ray
  • Patent number: 8026262
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: September 27, 2011
    Assignee: GlaxoSmithKline LLC
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, Andrew Larkin, Huiquiang Zhou, Eugene L. Stewart, Katherine Stetson, Darryl Lynn McDougald, Amarjit Sab Randhawa, John A. Ray
  • Publication number: 20100240642
    Abstract: The present invention relates to certain indole derivatives that are modulators of PPAR?, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine.
    Type: Application
    Filed: August 31, 2007
    Publication date: September 23, 2010
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Jeffrey Alan Oplinger, Paul Kenneth Spearing, Millard Hurst Lambert, John A. Ray, Christopher P. Laudeman, Jerzy R. Szewczyk, Pierette Banker
  • Publication number: 20090264482
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Application
    Filed: July 1, 2009
    Publication date: October 22, 2009
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, Andrew Larkin, Huiquiang Zhou, Eugene L. Stewart, Katherine Stetson, Darryl Lynn McDougald, Amarjit Sab Randhawa, John A. Ray
  • Patent number: 7572820
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: August 11, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla, Andrew Larkin, Huiquiang Zhou, Eugene L. Stewart, Katherine Stetson, Darryl Lynn McDougald, Amarjit Sab Randhawa, John A. Ray
  • Patent number: 7402606
    Abstract: Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.
    Type: Grant
    Filed: April 1, 2003
    Date of Patent: July 22, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: David Gene Barrett, John G. Catalano, David Norman Deaton, Aaron Bayne Miller, John A. Ray, Vicente Samano
  • Publication number: 20080139631
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Application
    Filed: September 27, 2007
    Publication date: June 12, 2008
    Applicant: SmithKline Beecham Corporation
    Inventors: Philip Stewart TURNBULL, Rodolfo Cadilla, Andrew Larkin, Huiquiang Zhou, Eugene L. Stewart, Katherine Stetson, Darryl Lynn McDougald, Amarjit Sab Randhawa, John A. Ray
  • Patent number: 5569829
    Abstract: A method is provided for making fruit (particularly tomatoes) having increased solids content which comprises cultivating fruit-bearing plants in which expression of genes homologous to pTOM36 is at least partially inhibited. For this purpose the fruit may be transformed with DNA constructs comprising a DNA sequence homologous to some or all of the gene encoded by the clone pTOM36. The clone is adapted to generate sense or antisense RNA under control of a plant promoter.
    Type: Grant
    Filed: June 9, 1993
    Date of Patent: October 29, 1996
    Assignee: Imperial Chemical Industries
    Inventors: Colin R. Bird, Jeremy M. Boniwell, Donald Grierson, John A. Ray, Wolfgang W. Schuch
  • Patent number: 5484906
    Abstract: DNA clones, e.g. M13-1, comprising at least part of a gene derived from melon that encodes ethylene-forming enzyme. Such clones may comprise DNA constructs including plant promoters capable of expressing RNA in plant cells. Such constructs may be used to inhibit production of ethylene-forming enzyme in transformed plants, and thereby to produce slower-ripening fruit, particularly melons. The clones may be obtained by PCR using specific oligo-nucleotide primers.
    Type: Grant
    Filed: August 2, 1993
    Date of Patent: January 16, 1996
    Assignee: Zeneca Limited
    Inventors: Colin R. Bird, John A. Ray, Wolfgang W. Schuch
  • Patent number: 5449764
    Abstract: DNA clones, e.g. P13-B, comprising at least part of a gene derived from peach that encodes ethylene-forming enzyme. Such clones may comprise DNA constructs including plant promoters capable of expressing RNA in plant cells. Such constructs may be used to inhibit production of ethylene-forming enzyme in transformed plants, and thereby to produce slower-ripening fruit, particularly peaches. The clones may be obtained by PCR using specific oligo-nucleotide primers.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: September 12, 1995
    Assignee: Zeneca Limited
    Inventors: Colin R. Bird, John A. Ray, Wolfgang W. Schuch
  • Patent number: 5304490
    Abstract: DNA constructs useful for modifying the ripening behavior of fruit comprise a transcriptional initiation region operative in plants positioned for transcription of a DNA sequence homologous to some or all of a fruit-ripening gene encoded by either of the clones pTOM136 or pTOM66, so that the construct can generate RNA in plant cells. Also plant cells and plants transformed with such constructs.
    Type: Grant
    Filed: August 23, 1991
    Date of Patent: April 19, 1994
    Assignee: Imperial Chemical Industries PLC
    Inventors: Colin R. Bird, Ruper G. Fray, Donald Grierson, Grantley W. Lycett, John A. Ray, Wolfgang W. Schuch
  • Patent number: 5254800
    Abstract: DNA constructs comprise a DNA sequence homologous to some or all of the gene encoded by the clone pTOM36. The constructs may further comprise a transcriptional initiation region operative in plants for transcribing this DNA sequence, optionally in the antisense direction to produce mRNA complementary to the pTOM36 gene. Transformed plant cells and plants may be derived from such constructs: fruit from the plants (such as tomatoes) are expected to have modified ripening properties.
    Type: Grant
    Filed: October 19, 1990
    Date of Patent: October 19, 1993
    Assignee: Imperial Chemical Industries PLC
    Inventors: Colin R. Bird, Donald Grierson, John A. Ray, Wolfgang W. Schuch
  • Patent number: H531
    Abstract: Novel anilide derivatives of the formulaZ--ArwhereinZ is a heterocyclic ring system attached to Ar through a ring nitrogen atom in Z, andAr is a substituted phenyl ring, exhibit good control of broadleaf weeds and safety to important crops at low application rates.
    Type: Grant
    Filed: June 3, 1986
    Date of Patent: October 4, 1988
    Inventors: John A. Ray, Thomas N. Wheeler