Abstract: Provided herein are processes for manufacturing recombinant ranibizumab or a ranibizumab variant that include providing a liquid comprising recombinant ranibizumab or a ranibizumab variant that is substantially free of cells; capturing the recombinant ranibizumab or the ranibizumab variant in the liquid using an affinity chromatography column, wherein the eluate of the affinity chromatography column comprises the recombinant ranibizumab or the ranibizumab variant; purifying the recombinant ranibizumab or the ranibizumab variant in the eluate of step (b) using a first cation exchange chromatography column and buffers that have a pH of about pH 5.5 to about 7.

Abstract: A vehicle includes a powered door having an actuator to move the door between open and closed positions, a transceiver configured to communicate with one or more mobile devices, and an imaging device oriented to capture images in a region proximate to the powered door. A controller processes the captured images and controls the actuator to move the door to the open position when a mobile device is detected proximate the vehicle and a user is detected in the captured images located in a door detection zone. The controller moves the door to the open position when a face of a user is recognized as an authorized user located in the door detection zone. The controller moves the door to the open position when a gait of the user is detected and identifies the gait are indicative of an authorized user located in the door detection zone.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: An item repositioning method includes, in response to a request for an item, moving a vehicle along a first route to a location of the item, loading the item in the vehicle using a lift assist device mounted to the vehicle, moving the vehicle along a second route to transport the item to a desired location, and at the desired location, unloading the item from the vehicle using the lift assist device.

Abstract: A system can include an axial field rotary energy device with an axis of rotation and a rotor coaxial with the axis and having a shaft, bearings, rotor disks that are coaxial and permanent magnets on each rotor disk. A printed circuit board (PCB) stator is located between the rotor disks to define an air gap on each side of the PCB stator. An enclosure has two enclosure sections with an inspection port. Bearing caps and bearings are mounted to the rotor. A variable frequency drive (VFD) assembly is coupled to the axial field rotary energy device. The VFD has a flexible conduit that extends between the VFD housing and the axial field rotary energy device. The flexible conduit can adapt to different sizes of axial field rotary energy devices.

Abstract: In an aspect, a latch for a closure panel for a vehicle is provided, and includes a ratchet, pawl, release lever, and extension member. The ratchet is movable between a primary closed position, secondary closed position and open position. The pawl is movable between a primary locking position, secondary locking position and unlocking position. The release lever is movable between home and actuated positions. When the pawl is in the primary locking position the release lever has a selected amount of reach for driving the pawl to the secondary locking position during movement of the release lever to the actuated position. When the pawl is in the secondary locking position the extension member is movable to extend the reach of the release lever to drive the pawl from the secondary locking position to the unlocked position during movement of the release lever from the home position to the actuated position.

Abstract: A transfer key system for a vehicle may include a key receptacle configured to detect the presence of a transfer key, and a controller configured to receive key status signals from the key receptacle, and activate the transfer key as an active transfer key in response to the status signal indicating a removal of the transfer key from the key receptacle and receiving an authentication signal from a user.

Abstract: An anti-collision system for railcars and locomotives provides a distance ranging and worker coupling protection system utilizing remote-sensing radar techniques for use with a locomotive and railcar. The anti-collision system may include an object detector device attached to a railcar or a locomotive that detects objects in a path of the railcar and the locomotive and a train display device electrically connected to the object detector device. The anti-collision system may also include an emergency action device which enables a crew member to stop the railcar or locomotive without communication to a locomotive operator when a hazard is recognized. The object detector device may include a remote sensor, a radio, and a microprocessor programmed to include data-logging to record and log all data from the anti-collision system.

Abstract: A tailsitter aircraft includes an airframe, a thrust array attached to the airframe and a flight control system. The thrust array includes propulsion assemblies configured to transition the airframe from a forward flight orientation to a VTOL orientation at a conversion rate for an approach to a target ground location in a forward flight-to-VTOL transition phase. The flight control system implements an adaptive transition system including a transition parameter monitoring module configured to monitor parameters including a ground speed and a distance to the target ground location. The adaptive transition system includes a transition adjustment determination module configured to adjust the conversion rate of the airframe from the forward flight orientation to the VTOL orientation based on the ground speed and the distance to the target ground location such that the airframe is vertically aligned with the target ground location in the VTOL orientation of the forward flight-to-VTOL transition phase.

Abstract: A vehicle is provided that includes a vehicle body defining a cabin interior and comprising a front row of seats and a rear row of seats, a plurality of seats located within the cabin interior, and a monitoring system for detecting and monitoring a pet or passenger within the cabin interior. The vehicle also includes a movable center console positioned between a pair of the forward row of seats and forward of the rear row of seats and comprising a holder for holding a drink container, and a controller processing signals generated by the monitoring system and determining a location of the detected pet or passenger on the rear row of seats based on the processed signals, the controller further controlling the movable console between a forward first position and a rearward second position closer to the rear row of seats.

Abstract: Method and apparatus are disclosed for mobile device tethering for a remote parking assist system of a vehicle. A vehicle includes a camera and a body control module. The body control module sends an instruction to a mobile device and captures, with the camera, an image of the mobile device. The body control module also analyzes the image to determine an initial location of the mobile device relative to the vehicle, and based on the initial location, performs dead reckoning on the mobile device to track the mobile device. When the mobile device is within a threshold distance, the body control module enables autonomous parking.

Abstract: Disclosed herein are catheters having multiple coil layers, and associated systems and methods. In some embodiments, a catheter includes an inner liner, a plurality of wires over the inner liner, and an outer sheath over the wires. The wires are coiled about a longitudinal axis of the catheter in a first direction to form a first coil layer over the inner liner, and the wires are coiled about the longitudinal axis in a second direction, opposite the first direction, over the first coil layer to form a second coil layer over the first coil layer. The wires each include a continuous/self-terminating end portion wherein the wire switches from the first direction to the second direction and transitions from the inner coil layer to the outer coil layer.

Abstract: A cooling assembly includes an evaporator containing a primary cooling medium, a passive condenser, and a heat exchanger. When a secondary cooling medium is provided to the heat exchanger, the primary cooling medium in the gas phase switches from being received by the passive condenser to the heat exchanger without operating any valves located between the evaporator and the passive condenser and between the evaporator and the heat exchanger. The primary cooling medium circulates between the evaporator and the passive condenser and between the evaporator and the heat exchanger by natural circulation and gravity without a pump in the flow path of the primary cooling medium between the heat exchanger and the evaporator and between the passive condenser and the evaporator to circulate the primary cooling medium.

Abstract: A computer, including a processor and a memory, the memory including instructions to be executed by the processor to acquire a first image by illuminating a first object with a first light beam, segment the first image of the first object to determine regions that correspond to a first surface material and determine a first measure of pixel values in regions of the first image that correspond to the first surface material. The instructions include further instructions to perform a comparison of the first measure of pixel values to a second measure of pixel values determined from a second image of a second object, wherein the second image is previously acquired by illuminating the second object with a second light beam and when the comparison determines that the first measure is equal to the second measure of pixel values within a tolerance, determine that the first object and the second object are a same object.

Abstract: The display device of the present invention includes, in the following order toward a viewer: a display panel; a semi-transparent mirror; a Pancharatnam-Berry lens configured to cause one-handed circularly polarized light incident thereon that is left-handed circularly polarized light or right-handed circularly polarized light to converge while causing opposite-handed circularly polarized light incident thereon to diverge; and a circularly polarized light-selective reflector.

Abstract: A technique is provided for determining a loss risk assessment score for a vehicle trip. The technique includes, at a vehicle, a computing device receiving first information indicative of operation of the vehicle. The technique also includes, at the vehicle, the computing device receiving second information indicative of an environment at a particular location and time. The computing device correlates the first information and the second information to generate a data set. The technique also includes determining a score for the vehicle trip based at least in part upon the generated data set.

Abstract: A computer-implemented method includes receiving, by a storage system, encrypted data and a set of key identifiers. Each key identifier is associated with information specifying a storage location for which the key identifier is authorized. The method also includes storing, by the storage system, the encrypted data in at least one storage location and receiving, by the storage system, at least one key identifier of the set of key identifiers with a data access request. The method includes determining, by the storage system, whether the data access request is authorized for the at least one key identifier.

Abstract: Root certificates generated by root certificate authorities may be bound at the time of generation. In an example, a first root certificate can include an identity of a first root certificate authority, a first key identifier associated with a first key of the first root certificate authority and an identity of a first digital signature algorithm used by the first root certificate authority. The first root certificate can also include at least one extension including a second key identifier of a second key associated with the second root certificate authority and an identity of a second digital signature algorithm used by the second root certificate authority, the second digital signature algorithm being different from the first digital signature algorithm.

Abstract: A hand held electric pulse tool performs tightening operations in which torque is delivered in pulses to tighten a screw joint. The tool includes an output shaft and a sensor to determine a parameter value associated with tightening of the screw joint. The tool is operative to provide torque pulses on the output shaft in a tightening direction until a first parameter value associated with the tightening of the screw joint is reached, then pause the tightening during a first time interval, and then provide torque pulses on the output shaft in a loosening direction until a second parameter value is reached. Next the electrical pulse tool is operative to pause the tightening during a second time interval and provide torque pulses on the output shaft in the tightening direction until a third parameter value is reached.

Abstract: Disclosed is a wind turbine blade assembly and a method for its manufacture. The wind turbine blade assembly comprises a leading edge, a trailing edge, a blade shell with a trailing portion, and a flatback profile component. The trailing portion has an outwardly curving arc shape and the flatback profile is positioned so as to cover the trailing portion of the blade shell.