Abstract: The present invention relates to a cyclic peptide, a conjugate comprising said cyclic peptide and a lipopeptide building block, a bundle of said conjugates, a synthetic virus-like particle comprising at least one bundle of conjugates and pharmaceutical compositions comprising the same. The present invention further relates to said cyclic peptide, said conjugate said bundle of conjugates, said synthetic virus-like particle and said pharmaceutical compositions for use as a medicament, preferably for use in a method for preventing of an infectious disease or reducing the risk of an infectious disease, more preferably for use in a method for preventing or reducing the risk of an infectious disease associated with or caused by a respiratory syncytial virus.

Abstract: The present invention relates to a cyclic peptide, a conjugate comprising said cyclic peptide and a lipopeptide building block, a bundle of said conjugates, a synthetic virus-like particle comprising at least one bundle of conjugates and pharmaceutical compositions comprising the same. The present invention further relates to said cyclic peptide, said conjugate said bundle of conjugates, said synthetic virus-like particle and said pharmaceutical compositions for use as a medicament, preferably for use in a method for preventing of an infectious disease or reducing the risk of an infectious disease, more preferably for use in a method for preventing or reducing the risk of an infectious disease associated with or caused by a respiratory syncytial virus.

Abstract: The present invention relates to a lipopeptide building block consisting of (i) a peptide moiety comprising a coiled coil peptide chain segment, wherein said coiled coil peptide chain segment comprises 3 to 8 repeat units, and wherein said repeat unit consists of the sequence IEKKIE-XO (SEQ ID NO:58), wherein X0 represents an amino acid, and wherein preferably said repeat unit consists of the sequence selected from IEKKIEG (SEQ ID NO:59), IEKKIEA (SEQ ID NO:12) or IEKKIES (SEQ ID NO:13), and wherein further preferably said repeat unit consists of the sequence IEKKIES (SEQ ID NO:13); (ii) a lipid moiety comprising, preferably consisting of, the formula LM-I wherein R1 and R2 are independently C11-15alkyl, wherein preferably R1 and R2 are independently —C11H23, —C13H27 or —C15H31, and wherein further preferably R1 and R2 are —C15H31; and wherein R3 is hydrogen or —C(O)C11-15alkyl, and wherein preferably R3 is H or —C(O)C15H31; and wherein said lipid moiety is linked to said peptide moiety, wherein the wavy line

Abstract: The present invention relates to a cyclic peptide, a conjugate comprising said cyclic peptide and a lipopeptide building block, a bundle of said conjugates, a synthetic virus-like particle comprising at least one bundle of conjugates and pharmaceutical compositions comprising the same. The present invention further relates to said cyclic peptide, said conjugate said bundle of conjugates, said synthetic virus-like particle and said pharmaceutical compositions for use as a medicament, preferably for use in a method for preventing of an infectious disease or reducing the risk of an infectious disease, more preferably for use in a method for preventing or reducing the risk of an infectious disease associated with or caused by a respiratory syncytial virus.

Abstract: The invention relates to lipopeptide building blocks consisting of a peptide chain comprising a coiled-coil domain, linked covalently to a lipid moiety comprising long alkyl or alkenyl chains, and optionally linked to an antigen; and to helical lipopeptide bundles and synthetic virus-like particles formed by aggregation. The nanometer size and shape of these bundles and particles, their stability under aqueous physiological conditions, their chemical composition, the possibility to incorporate B- and T-cell epitopes, and their production by chemical synthesis, make them highly suitable as vaccine delivery vehicles.

Abstract: A power monitor for electronic devices, such as computer chips, is used to estimate the power consumption and to compare the estimated power consumption against the power budget. The estimated power consumption is based on activity signals from various functional blocks of the computer chip. The activity signals that are monitored correlate accurately to the total number of flip-flops that are active at a given time. If the estimated power consumption exceeds the power budget, the speed of the clock signals supplied to the computer chip is reduced.

Abstract: The invention sets forth an approach to context switching that utilizes scan chains modified to perform context switching operations. The design requires substantially less additional silicon area and design engineering effort than existing context switch approaches, while operating substantially faster and providing additional debug observability during context switching operations.

Abstract: The present invention provides reagents, compounds, compositions, and methods relating to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5), and/or LRP6 with Dkk, including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and methods of treatment of the present invention are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and/or bone mass and is useful in the treatment and diagnosis of abnormal lipid levels and bone mass disorders, such as osteoporosis.

Abstract: The invention relates to lipopeptide building blocks consisting of a peptide chain comprising a coiled-coil domain, linked covalently to a lipid moiety comprising long alkyl or alkenyl chains, and optionally linked to an antigen; and to helical lipopeptide bundles and synthetic virus-like particles formed by aggregation. The nanometer size and shape of these bundles and particles, their stability under aqueous physiological conditions, their chemical composition, the possibility to incorporate B- and T-cell epitopes, and their production by chemical synthesis, make them highly suitable as vaccine delivery vehicles.

Abstract: On the fly tuning of parameters used in an interface between a memory (e.g. high speed memory such as DRAM) and a processor requesting access to the memory. In an operational mode, a memory controller couples the processor to the memory. The memory controller can also inhibit the operational mode to initiate a training mode. In the training mode, the memory controller tunes one or more parameters (voltage references, timing skews, etc.) used in an upcoming operational mode. The access to the memory may be from an isochronous process running on a graphics processor. The memory controller determines whether the isochronous process may be inhibited before entering the training mode. If memory buffers for the isochronous process are such that the training mode will not impact the isochronous process, then the memory controller can enter the training mode to tune the interface parameters without negatively impacting the process.

Abstract: Template-fixed ?-hairpin loop mimetics comprising a template corresponding to one of the structures (a), (b), (c), (d), (e), (f), (g), (h) and a template-fixed chain of 4 to 20 ?-amino acid residues which, if their ?-C atom is asymmetric, have L-configuration can be manufactured by a novel process which is based on a mixed solid- and solution phase synthetic strategy. If desired, this process can be modified to give the enantiomers of these template-fixed ?-hairpin loop mimetics. These enantiomers are novel compounds, and many of said template-fixed ?-hairpin loop mimetics themselves are also novel compounds. The template-fixed ?-hairpin loop mimetics and their enantiomers can mimic flat surfaces of proteins and thus be used to probe large surface protein-protein interactions. Accordingly they can serve as lead finding tools for protein targets where it is difficult to find small-molecular-weight lead compounds.

Abstract: Template-fixed ?-hairpin loop mimetics comprising a template corresponding to one of the structures (a), (b), (c), (d), (e), (f), (g), (h) and a template-fixed chain of 4 to 20 ?-amino acid residues which, if their ?-C atom is asymmetric, have L-configuration can be manufactured by a novel process which is based on a mixed solid- and solution phase synthetic strategy. If desired, this process can be modified to give the enantiomers of these template-fixed ?-hairpin loop mimetics. These enantiomers are novel compounds, and many of said template-fixed ?-hairpin loop mimetics themselves are also novel compounds. The template-fixed ?-hairpin loop mimetics and their enantiomers can mimick flat surfaces of proteins and thus be used to probe large surface protein-protein interactions. Accordingly they can serve as lead finding tools for protein targets where it is difficult to find small-molecular-weight lead compounds.

Abstract: Conformationally constrained peptidomimetics of the Circumsporozoite protein found on the surface of malaria parasites, as well as methods of making the same are provided. These peptidomimetics can be linked to human compatible delivery vehicles for the generation of protective immune responses against malaria.

Abstract: The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory antibodies. The cyclized or linear peptides can be applied by known adjuvants or be encapsulated by or attached onto the surface of liposomes or virosomes (IRIVs) which serve as human compatible antigen delivery systems. Both cyclized and linear versions of the peptide antigens are surprisingly effective in eliciting immune responses that are cross-reactive with parasite-expressed AMA-1.

Abstract: A folding stowable trolling rig for removably mounting a plurality of fishing rods in desired, operable positions above the deck of a boat, such rig mounting atop a standard fishing seat pedestal of the type found on bass boats and requiring no tools or special hardware for installation. It is comprised of a plurality of longitudinally spaced rod holders pivotally mounted to a pair of folding support arms, one end of each being pivotally attached to either side of a central mounting base, the underside of which having a post that inserts into the seat mounting socket atop the fishing seat pedestal. Automatic alignment of each rod holder, both in folded and opened positions, is controlled by a pair of alignment bars pivotally mounted to the holders and to either side of the mounting base just above and parallel to the support arms. The rod holders and the support arms all fold together into compact alignment for transporting or stowing.

Abstract: A dynamic terrain display is created from digitized grid post data as a height field, that is textured using maps embracing progressively larger areas with increasing remoteness from the viewpoint. A truncated pyramid is defined by map parts for each level that are maintained in active memory. The map parts or fragments are stored in rectangular configurations to be updated row-by-row or column-by-column, by overwriting obsolete data in a circular manner to reflect changes in the viewpoint. Levels of the map parts accordingly are paged independently of each other from database storage. Not all levels are required to have texture in that if a level is not available, a lower level can be employed. Theme cells also can be utilized.

Abstract: Disclosed is a new single handle post hole digger for excavating a constant diameter shaft in the ground for setting fence posts and the like. The single handle post hole digger comprises a stationary arcuate shovel blade pivotally connected to a movable arcuate shovel blade. The movable blade has an earth piercing position wherein the movable blade lies parallel to the stationary blade such that the extended arcs of the blades describe a cylinder. The movable blade also has an earth removing position wherein the lower edge of the movable blade is angled inwardly toward the stationary blade to define a scoop. An elongated gripping handle extends longitudinally from the blades. Blade control is accomplished with an actuator lever, pivotally mounted on the gripping handle, connected to the movable shovel blade by a control rod. Moving the lever in one direction positions the movable blade for earth piercing whereas moving the lever in the other direction positions the movable blade for earth removing.

Abstract: A system is disclosed for the production of real-time, computer-generated images as for projection on a curvilinear surface as on the inside of a dome. A general-purpose computer provides data for visual images and supplies the data in an ordered format. Such data is processed first with regard to viewpoint and second with regard to channel operation. Specifically, viewpoint processing incorporates an object manager and a polygon manager. Channel processing includes a geometric processor and a display processor. The display processor drives a projector for illuminating a spherical surface with the desired images. The geometric processor incorporates several well known elements including a rotator, clippers, a slope calculator and polygon buffer. Additionally, the geometric processor incorporates a segmenter and mapper which replaces the traditional perspective divider to process the data so as to generate images for curvilinear projection.

Abstract: It is important that in an optical fibre connector the ends of the fibres should contact or very nearly contact to avoid excessive optical losses. They must be accurately aligned and lateral movements, causing varying optical output, be minimized. In this invention, the fibre or fibres are secured in grooves formed in flat surfaces in two abutting blocks and the blocks are clamped together with their flat surfaces in contact with a further flat surfaced member. The clamp consists of a cam surface formed in a housing which is adapted to contact a portion of the further member when the blocks are introduced into the housing.