Abstract: Liquid pharmaceutical liquid compositions that are orally administered and methods for their use by administration to the lungs for multifunctional treatment of lung and respiratory diseases.

Abstract: Methods of use and pharmaceutical liquid compositions that are orally administered to the lungs through vaporization and aerosol generating devices providing multifunctional treatment for lung and respiratory diseases are presented.

Abstract: A system and method for detecting or identifying substances based on spectral response signatures is provided. The system utilizes IR imagery, singularly or stored in a database, in operative communication with a database or library of known spectral response signatures. The system correlates the spectral response signature detected, or inherent, in an image or image library, with the set of known signatures in the spectral database. The system generates a report of the substances or chemical compounds present in at least a portion of the image. The system can also query a database of IR products for an area of interest, and return results in a report or via an interactive tool, for IR products containing specific IR spectral results.

Abstract: A system and method for detecting or identifying substances based on spectral response signatures is provided. The system utilizes IR imagery, singularly or stored in a database, in operative communication with a database or library of known spectral response signatures. The system correlates the spectral response signature detected, or inherent, in an image or image library, with the set of known signatures in the spectral database. The system generates a report of the substances or chemical compounds present in at least a portion of the image. The system can also query a database of IR products for an area of interest, and return results in a report or via an interactive tool, for IR products containing specific IR spectral results.

Abstract: A training apparatus 2 including a mannequin 4, for being struck by a person training for fighting, the apparatus comprising a support structure 6 for supporting the mannequin, the mannequin including a head 16, a torso, two arms 76 (having upper and lower arms) and two legs 10, and having joints at the shoulders 50, hips 56, knees 54 and elbows 52, wherein the joints at the shoulders are configured to variably adjust and fix the position of the upper arms relative to the torso in at least two orthogonal planes, and the joints at the elbows are configured to variably adjust and fix the position of the lower arms relative to the upper arms in at least one plane, the apparatus including ankle attachment means for removably attaching the ankles to the support structure.

Abstract: A training apparatus 2 including a mannequin 4, for being struck by a person training for fighting, the apparatus comprising a support structure 6 for supporting the mannequin, the mannequin including a head 16, a torso, two arms 76 (having upper and lower arms) and two legs 10, and having joints at the shoulders 50, hips 56, knees 54 and elbows 52, wherein the joints at the shoulders are configured to variably adjust and fix the position of the upper arms relative to the torso in at least two orthogonal planes, and the joints at the elbows are configured to variably adjust and fix the position of the lower arms relative to the upper arms in at least one plane, the apparatus including ankle attachment means for removably attaching the ankles to the support structure.

Abstract: A mailer intermediate includes a generally rectangular sheet of printable, postcard stock having first and second side edges, first and second end edges, and first and second faces. A fold line extends substantially transverse to the side edges and substantially bisects them, whereby the sheet is divided by the fold line into first and second postcard portions. An adhesive pattern is provided on the first face of the sheet, adjacent at least one of the first and second end edges, for securing the first and second postcard portions together adjacent the first and second end edges. Adhesive patterns on the first face of the sheet adjacent the first and second side edges are provided only near the fold line, whereby the first face of the first and second postcard portions are not adhered together along a substantial majority of the extent of the first and second side edges of the first and second postcard portions. The fold line may be defined by a line of weakness, such as for example a perforation line.

Abstract: The present invention relates to methods of generating chimeric oligonucleotides without the need for subcloning. The methods of the invention are polymerase-based, and may optionally be adapted for use with reagents available in commercially available mutagenesis kits such as Stratagene's QCM kits, to generate chimeric oligonucleotides in a quick, efficient and cost-effective manner. Major applications of this method include vaccine production, directed evolution and other areas that benefit from the development of diversity.

Abstract: The present invention relates to methods of generating chimeric oligonucleotides without the need for subcloning. The methods of the invention are polymerase-based, and may optionally be adapted for use with reagents available in commercially available mutagenesis kits. Major applications of this method include directed evolution and other areas that benefit from the development of diversity.

Abstract: The present invention relates to improved methods of introducing site-directed mutations into circular DNA without the need for subcloning. The invention comprises single-stage, polymerase-based, mutagenesis procedures which eliminate the need for the second-stage linear cyclic amplification reaction of the prior art. In accordance with the invention, production of complimentary mutagenized DNA strands is accomplished in separate, single-primer, linear amplification reactions carried out for each primer of a mutagenic primer pair. The mutagenized DNA strands produced in the separate primer reactions are combined and annealed and the resulting double-stranded mutagenized DNA intermediate may then be used directly to transform a host cell for further production of the desired mutant DNA. Major applications of this method include directed evolution and other areas that benefit from the development of diversity.

Abstract: The present invention relates to improved methods of introducing combinatorial mutations in a region of DNA without the need for subcloning. The invention comprises polymerase-based, mutagenesis methods which may be adapted for use with commercially available mutagenesis kits to generate combinatorial mutations of a region of DNA in a quick, efficient and cost-effective manner. Major applications of this method include vaccine production, directed evolution and other areas that benefit from the development of diversity.

Abstract: The invention relates to primers, libraries of primer, kits and methods for site-specific in vitro mutagenesis comprising: (a) cloning a parental polynucleotide into a vector comprising a cloning site, thereby obtaining a cloned product; (b) denaturing the cloned product, thereby obtaining a single-stranded polynucleotide template; (c) hybridizing at least one mutagenized oligonucleotide primer to the single-stranded polynucleotide template, thereby obtaining a first heteroduplex; (d) subjecting the first heteroduplex to linear amplification, thereby obtaining amplified products; (e) reacting the amplified products with a ligase, thereby obtaining ligated products; (f) denaturing the ligated products, thereby obtaining single stranded mutated polynucleotides; (g) hybridizing the single stranded mutated polynucleotides with a second oligonucleotide primer thereby obtaining second hybridized complexes; (h) copying the second hybridized complex and ligating the double stranded product thereof; thereby obtaining

Abstract: Method for automatic community model generation based on uni-parity data. Correlation analysis is employed to identify links within the community. Method may be particularized for solving specific problems such as determining the activities between individuals within a money laundering ring.

Abstract: A mailer intermediate includes a generally rectangular sheet of printable, postcard stock having first and second side edges, first and second end edges, and first and second faces. A fold line extends substantially transverse to the side edges and substantially bisects them, whereby the sheet is divided by the fold line into first and second postcard portions. An adhesive pattern is provided on the first face of the sheet, adjacent at least one of the first and second end edges, for securing the first and second postcard portions together adjacent the first and second end edges. Adhesive patterns on the first face of the sheet adjacent the first and second side edges are provided only near the fold line, whereby the first face of the first and second postcard portions are not adhered together along a substantial majority of the extent of the first and second side edges of the first and second postcard portions. The fold line may be defined by a line of weakness, such as for example a perforation line.

Abstract: Methods for activation of a constitutive nitric oxide synthase are described, as are agents which activate a constitutive nitric oxide synthase (e.g., NADPH analogs), methods of identifying such agents, and methods of treatment of diseases or conditions associated with nitric oxide production by a constitutive nitric oxide synthase, by administering an agent which activates the constitutive nitric oxide synthase.

Abstract: A strategy-type soccer board game has a plurality of movable playing pieces and a separate soccer ball, all of which may be moved independently of each other or in concert as determined by rolls of the dice. The game is played by two players, each of whom is given nine playing pieces. Each of the playing pieces has a post at its base onto which a ball having a matching slot may be placed when a particular playing piece is carrying or passing the ball. The game board consists of a rectangular playing field with a grid of squares, each square representing one possible move. Surrounding the field are the out-of-bounds areas. At opposing ends of the field are goal lines, a goal net which must be entered to score a goal and a goalie box. In the center of the field is a kick-off circle and a kick-off square from which the team kicking off initiates play. A table of numbers is located on each player's side of the board, indicating the direction of movement possible depending on the numbers rolled on the dice.

Abstract: A ventilated, splash-resistant electrical component housing assembly adapted to allow free flow of air throughout the housing assembly in order to provide cooling of electrical components therein. A main housing body (2) having a plurality of openings (12) along with means to retain electrical components (4) with the main body is disclosed. A top cover (30) having exterior notches (42) and an interior wall (46) with interior notches (48) is attached to the main body (2) and a bottom cover (14) having vent channels (19) is secured to the main body (2) in order to shield the electrical components and simultaneously to allow the free flow of air throughout the housing assembly.