Abstract: This invention is an improved method and kit for producing a desired channel or pathway in the interlamellar space in the corneal stroma for inserting a biocompatible material. The biocompatible polymer may be an intrastromal corneal ring (ICR). The method involves the use of clockwise and counter-clockwise dissectors, and optionally channel connectors and finish channel connectors. The kit contains clockwise and counter-clockwise dissectors and optionally channel connectors, finish channel connectors and probes.

Abstract: A tissue sample collection assembly collects undamaged cells from a tissue specimen comprising a damaged tissue layer at a margin thereof. The assembly includes a tissue-severing device used to separate at least a portion of the damaged tissue layer. The tissue-severing device may have a tissue-adhesive surface so that undamaged cells may contact and adhere to the tissue-adhesive surface for subsequent analysis. The assembly may comprise an apertured device comprising inner and outer surfaces with apertures passing therebetween. The apertures may be sized and shaped so that when the inner surface of the apertured device is pressed against a tissue specimen, portions of an undamaged tissue layer of the tissue specimen pass through the apertures and past the outer surface so that the tissue-severing device can sever the undamaged tissue layer portions from the remainder of the tissue specimen. Exposed undamaged tissue may adhere to a tissue-adhesive surface of the tissue-severing device.

Abstract: This invention is an improved method and kit for producing a desired channel or pathway in the interlamellar space in the corneal stroma for inserting a biocompatible material. The biocompatible polymer may be an intrastromal corneal ring (ICR). The method involves the use of clockwise and counter-clockwise dissectors, and optionally channel connectors and finish channel connectors. The kit contains clockwise and counter-clockwise dissectors and optionally channel connectors, finish channel connectors and probes.

Abstract: Hematology control compositions and systems used to measure a plurality of parameters in a blood sample are provided. The hematology control compositions are particularly useful as a control for multi-parameter, automated instrument systems. The control compositions comprise a reticulocyte component, a white blood cell component, a red blood cell component, a nucleated red blood cell component, a platelet component and a reticulated platelet component. Methods of making and using the control compositions are also provided.

Abstract: Hematology control compositions and systems used to measure a plurality of parameters in a blood sample are provided. The hematology control compositions are particularly useful as a control for multi-parameter, automated instrument systems. The control compositions comprise a reticulocyte component, a white blood cell component, a red blood cell component, a nucleated red blood cell component, a platelet component and a reticulated platelet component. Methods of making and using the control compositions are also provided.

Abstract: Hematology control compositions and systems used to measure a plurality of parameters in a blood sample are provided. The hematology control compositions are particularly useful as a control for multi-parameter, automated instrument systems. The control compositions comprise a reticulocyte component, a white blood cell component, a red blood cell component, a nucleated red blood cell component, a platelet component and a reticulated platelet component. Methods of making and using the control compositions are also provided.

Abstract: A device and method for refractive correction of the eye in order to improve the vision of the eye. The device is an intrastromal corneal ring (ICR) where the cone angle &thgr; is varied according to the desired change in corneal refractive properties. The method involves the insertion of the ICR with appropriate cone angle for the desired change those properties.

Abstract: Instruments and methods are provided which permit a surgeon to implant multiple radial inserts within a patient's cornea through one or more incisions made into the cornea. Instruments provided by the invention include a corneal marker, a radial pocket-forming instrument, and a positioning instrument. In one method provided by the invention, the surgeon uses the corneal marker to mark the patient's cornea with an incision mark, radial pocket marks, and circumferential channels marks simultaneously. The surgeon forms clockwise and counter-clockwise intrastromal circumferential channels through a single incision into the cornea, and then the surgeon inserts the radial pocket-forming instrument through the incision and into one of the circumferential channels to form radial pockets beneath the radial pocket marks. The surgeon inserts radial intrastromal inserts through the incision and into the circumferential channels and positions them within the radial pockets using the positioning instrument.

Abstract: The invention relates to a corneal pocketing tool for separating the lamella of the cornea. The corneal pocketing tool has a dissector portion for insertion into a corneal incision and a reference surface or region adapted to contact the cornea. As the dissector is advanced into the corneal incision the reference region comes into contact with the surface of the cornea and resists further advancement of the dissector. As the reference region is moved in a clockwise or counterclockwise direction, the dissector portion follows in the same direction forming a pocket in the cornea.

Abstract: Hematology control compositions and systems used to measure a plurality of parameters in a blood sample are provided. The hematology control compositions are particularly useful as a control for multi-parameter, automated instrument systems. The control compositions comprise a reticulocyte component, a white blood cell component, a red blood cell component, a nucleated red blood cell component, a platelet component and a reticulated platelet component. Methods of making and using the control compositions are also provided.

Abstract: This invention is a vacuum centering device which may be used in conjunction with other surgical instruments in opthomological surgery. The device provides an improved interface with the eye by way of features that reduce interference with a patient's eyelids interocular pressure and/or the propensity to rotate. These features may include a flared outer wall portion which may either be curved or straight for a section, providing a low profile vacuum chamber, and/or the use of a non-circular outer sealing region potentially producing a saddle-shaped outer periphery providing for potentially increased vacuum exposure to the eye and a contour resistant to rotation.

Abstract: A radially self-expanding stent particularly suited for treating esophageal strictures, includes a medial region and proximal and distal cuffs having diameters greater than the medial region diameter when the stent is in the relaxed state. A silicone coating circumscribes the medial region, but the cuffs are not coated and retain their open weave construction. As a result, the cuffs remain particularly well suited to immediately contact esophageal wall tissue and resist stent migration, while the silicone coated medial region provides a barrier to tumor ingrowth, and has an enhanced radial restoring force to maintain an open passageway in the esophagus. A deployment device for the stent includes an interior catheter surrounded by the stent and having an esophageal dilation feature, along with an exterior catheter that radially compresses the stent.

Abstract: A device for introducing a corneal implant into a cornea of a human eye. The device includes a body, a member coupled thereto, and a guide portion. The body has a distal end and a proximal end. The guide portion is disposed at the distal end of the body and forms a channel. The guide portion is configured for laterally supporting the implant when positioned in the channel and the member is arranged to axially support the implant when positioned in the channel.

Abstract: This invention is an improved method and kit for producing a desired channel or pathway in the interlamellar space in the corneal stroma for inserting a biocompatible material. The biocompatible polymer may be an intrastromal corneal ring (ICR). The method involves the use of clockwise and counter-clockwise dissectors, and optionally channel connectors and finish channel connectors. The kit contains clockwise and counter-clockwise dissectors and optionally channel connectors, finish channel connectors and probes.

Abstract: This invention is an improved method and kit for producing a desired channel or pathway in the interlamellar space in the corneal stroma for inserting a bio-compatible material. The method involves the use of clockwise and counter-clockwise dissectors and optionally channel connectors and finish channel connector.

Abstract: A radially self-expanding stent particularly suited for treating esophageal strictures, includes a medial region and proximal and distal cuffs having diameters greater than the medial region diameter when the stent is in the relaxed state. A silicone coating circumscribes the medial region, but the cuffs are not coated and retain their open weave construction. As a result, the cuffs remain particularly well suited to immediately contact esophageal wall tissue and resist stent migration, while the silicone coated medial region provides a barrier to tumor ingrowth, and has an enhanced radial restoring force to maintain an open passageway in the esophagus. A deployment device for the stent includes an interior catheter surrounded by the stent and having an esophageal dilation feature, along with an exterior catheter that radially compresses the stent.

Abstract: A radially self-expanding stent having multiple layers includes a medial region and proximal and distal cuffs having diameters greater than the medial region diameter when the stent is in the relaxed state. A silicone coating circumscribes at least the medial region of the stent. A deployment device for the stent includes an inner tube surrounded by the stent along with an outer tube that radially compresses the stent. A low durometer sleeve, fixed to the inner tube and in surface engagement with the compressed stent, tends to fix the axial position of the stent relative to the inner tube whenever the outer tube is moved axially relative to the inner tube. Consequently, precision in stent placement and the ability to recapture a partially deployed stent are enhanced.