Patents by Inventor John A. Secrist

John A. Secrist has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR TREATING AND PREVENTING ARTHRITIS
    Publication number: 20080234275
    Abstract: Compounds represented by the formula 1: wherein each R individually is H, an aliphatic acyl group or an aromatic acyl group; A is selected from the group consisting of wherein X is selected from the group consisting of hydrogen, halo, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro; are used to treat or prevent arthritis including rheumatoid arthritis.
    Type: Application
    Filed: March 24, 2008
    Publication date: September 25, 2008
    Applicant: Southern Research Institute
    Inventors: John A. Secrist, William R. Waud, Zhican Qu, Xiangmin Cui
  • Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof
    Publication number: 20030228576
    Abstract: The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside phosphorylase or hydrolase. The transformed or transfected procaryotic host cell can be used in combination with a purine substrate to treat tumor cells and/or virally infected cells. The present invention provides nucleotide sequences encoding mutant E. coli derived purine nucleoside phosphorylase proteins which can be used in conjunction with an appropriate substrate to produce toxins which impair abnormal cell growth. The invention provides for delivery of the toxin by generation within target cells or by administration and delivery to the cells from without.
    Type: Application
    Filed: October 26, 2001
    Publication date: December 11, 2003
    Inventors: Steven E. Ealick, William B. Parker, John A. Secrist, Eric J. Sorscher
  • Preparation of thioarabinofuranosyl compounds and use thereof
    Publication number: 20030203872
    Abstract: Patients suffering from cancer are treated by being administered a compound represented by the following formula: 1
    Type: Application
    Filed: April 7, 2003
    Publication date: October 30, 2003
    Inventors: John A. Secrist, Kamal N. Tiwari, John A. Montgomery
  • 4'-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof
    Publication number: 20030144235
    Abstract: Compounds represented by the formula 1: 1
    Type: Application
    Filed: September 9, 2002
    Publication date: July 31, 2003
    Inventors: John A. Secrist, Kamal N. Tiwari, John A. Montgomery
  • Method for prevention or treatment of acute allograft rejection and a pharmaceutical composition therefor
    Publication number: 20020151601
    Abstract: A method for treating an organ donor prior to harvesting organ to reduce graft rejection in a recipient.
    Type: Application
    Filed: April 17, 2002
    Publication date: October 17, 2002
    Inventors: Herbert M. Blatter, Donald R. Kahn, James R. Piper, John A. Secrist, Robert F. Struck, Carroll Temple
  • Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages
    Patent number: 5561225
    Abstract: The present invention provides for the preparation and use of ribo- and deoxyribo-nucleosides and polynucleotide analogs. The polynucleotide analogs are made of polynucleosides which contain sulfonate and sulfonamide linkages.
    Type: Grant
    Filed: September 19, 1990
    Date of Patent: October 1, 1996
    Assignee: Southern Research Institute
    Inventors: Joseph A. Maddry, Robert C. Reynolds, John A. Secrist, John A. Montgomery, Peter A. Crooks