Abstract: A computer-based system and related methods for improving and sustaining patient adherence, compliance and persistence with a medication plan, regimen or regime. The system works with a particular prescription medication or medications, or for a daily or periodic regimen of multiple prescription medications. It provides real-time reminders and alerts to patients for quality-assured patient self-administration of medication at the correct point in time for each scheduled medication dose, and determines adherence scores and ratings for a variety of medication adherence factors. It can be accessed on mobile computing devices, or through a web-based browser.