Abstract: The invention relates to benzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: A glass container for storing pharmaceutical formulations may include a glass body formed from a Type IA or Type IB glass composition according to ASTM Standard E438-92(2011). The glass body may include a wall portion with an inner surface and an outer surface, a heel portion and a floor portion, wherein the inner surface of the glass container is formed by the inner surface of the glass body. The glass body may include at least a class A2 base resistance or better according to ISO 695, at least a type HGB2 hydrolytic resistance or better according to ISO 719 and Type 1 chemical durability according to USP <660>. The glass container does not comprise a boron-rich layer on the inner surface of the glass body in as formed condition.

Abstract: The invention relates to imidazopyridines of Formula (I) and pharmaceutically acceptable salts thereof, wherein R0 to R5 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: Provided is a method of transportation information exchange that includes receiving first data from a first aviation data source, such that the first data is provided in a first data format type and determining, based on a set of routing rules, a first aviation consumer of at least a first portion of the first data. The method further includes processing the first portion of the first data into a second data format type associated with the first aviation consumer and providing the first portion of the first data in the second data format type to the first aviation consumer.

Abstract: An apparatus is provided to test valves. The apparatus includes an actuation mechanism having an actuator that seals a valve of a combustion chamber of an engine. The apparatus further includes a flow control device that controls a flow of a pressurized fluid to the combustion chamber. The apparatus further includes a plurality of sensors having a first sensor and a second sensor. The first sensor is disposed in an inlet port of the combustion chamber to detect a first flow rate of the pressurized fluid in the inlet port. The second sensor is disposed in an exhaust port of the combustion chamber to detect a second flow rate of the pressurized fluid in the exhaust port. The apparatus further includes a notification device configured to generate an alert based on the detected first flow rate and the detected second flow rate.

Abstract: A support for a sheet of glass is disclosed. The support comprises first and second support assemblies each comprising a respective base and arm assembly. Each arm assembly comprises a respective first arm having first and second ends and a first contact surface at each end thereof for contacting a first major surface of the sheet of glass when the sheet of glass is supported on the support. Each arm assembly is coupled to the respective base by a respective coupling for rotation about a pivot axis. Any of the first contact surfaces may be provided by a ball castor or wheel. The support is useful when supporting the glass sheet wherein a measurement of the shape thereof is required because the support is able to quickly reach an equilibrium configuration. A method of supporting a glass sheet using the support is also disclosed.

Abstract: A coated glass pharmaceutical package includes a glass body having a Type 1 chemical durability according to USP 660, at least a class A2 base resistance or better according to ISO 695, and at least a type HGB2 hydrolytic resistance or better according to ISO 719, the glass body having an interior surface and an exterior surface and a wall extending therebetween. A lubricous coating having a thickness of less than or equal to 90 nm may be positioned on at least a portion of the exterior surface of the glass body but not on any portion of the interior surface. The portion of the coated glass package with the lubricous coating comprises a coefficient of friction that is at least 20% less than an uncoated glass package and the coefficient of friction does not increase by more than 30% after undergoing a depyrogenation cycle including exposure to a temperature of 250° C. for a time period of 30 minutes.

Abstract: A vehicle seat and storage system includes a vehicle seat having a seat base and a seat back extending from the seat base. A storage apparatus is connected to the seat back and is movable from a stowed position against the seat back to an extended position away from the seat back. The storage apparatus is configured to position and secure one or more cargo items. A seat motor is operably connected to the seat. The seat motor is configured to move the seat back from a first position extending upward from the seat base to a second position where the seat back is disposed flat against the seat base.

Abstract: An apparatus is provided to test valves. The apparatus includes a support structure and a plurality of engagement members coupled to the support structure. Each member of the plurality of engagement members is coupled with a valve of a valve train associated with an engine head. The apparatus further includes a camshaft, which includes a plurality of lobes coupled to the support structure. Each lobe of the plurality of lobes are equally spaced from each other and coupled to a member of the plurality of engagement members. The apparatus further includes a driving mechanism coupled to the camshaft, which is configured to rotate the camshaft and control each member of the plurality of engagement members to further control an activation of each valve of the valve train associated with the engine head.

Abstract: A method of simultaneous multiuser collaborative access to a spreadsheet includes transmitting the spreadsheet to a first device of a first user having a first privilege for a first part that includes a first cell, transmitting the spreadsheet to a second device of a second user having a second privilege for a second part, receiving a first edit of the first cell from the first device, and a second edit of the second cell from the second device, and in response to the first cell and the second cell being different, the first privilege including an edit privilege, and the second privilege including the edit privilege, accepting the first edit, accepting the second edit, forwarding the first edit for display with the first cell at the second device, and providing, to the second device, a real-time visual indication identifying the first user as a last user editing the first part.

Abstract: Embodiments of the present disclosure are directed to coated glass articles which reduce glass particle formation caused by glass to glass contact in pharmaceutical glass filling lines.

Abstract: According to embodiments, a coated pharmaceutical container may include a pharmaceutical container comprising an interior surface and an exterior surface, wherein the pharmaceutical container may include a glass composition that has Class HGA1 hydrolytic resistance when tested according to the ISO 720 testing standard. The coated pharmaceutical container may further include a coating bonded to at least a portion of the exterior surface but not on any portion of the interior surface. The coating may have a coefficient of friction less than or equal to 0.7, and the coated pharmaceutical container may be thermally stable after heating at a temperature of at least 260° C. for a time period of 30 minutes.

Abstract: Aspects of the disclosure are directed to data communication with transmission rate adjustment. As may be implemented in accordance with one or more embodiments herein, such aspects may involve comparing the transmission rate at which packets are communicated from a transmitter, with a reception rate at which the packets are received at a receiver. The transmission rate at which further packets are communicated from the transmitter is adjusted in response to and/or otherwise based on the comparison.

Abstract: A method for dynamically generating or interacting with an electromagnetic field includes providing a spatial array of conductive segments, a switching device operable on each of the conductive segments to either allow or block transmission of an electrical signal and a control device operable on the switching device. A sequence of the conductive segments are connected to form a conductive path where each segments intersects with at least two different ones of the conductive segments at a node. The switching device operates to connect a selected first one of the conductive segments with a selected second one of the conductive segments to form the sequence according to a logic signal from the control device. Power is supplied to the conductive path to produce an electromagnetic field which depends at least in part on the spatial arrangement of the connected sequence of the conductive segments.

Abstract: The disclosures herein relate to compounds of Formula (1?): or a salt thereof, wherein A, Q, X, Z, L, R2, R3 and R9 are defined herein, and their use in the treatment of SARS-CoV-2 and related viruses and disorders associated with SARS-CoV-2: Mpro.

Abstract: Various embodiments are disclosed for improved and structurally optimized transistors, such as RF power amplifier transistors. A transistor may include a drain metal portion raised from a surface of a substrate, a drain metal having a notched region, a gate manifold body with angled gate tabs extending from the gate manifold, and/or a source-connected shielding. The transistor may include a high-electron-mobility transistor (HEMT), a gallium nitride (GaN)-on-silicon transistor, a GaN-on-silicon-carbide transistor, or other type of transistor.

Abstract: A method and apparatus for testing and simulating an access control policy are disclosed. Evaluating an access control policy may be performed by utilizing a deny statement that causes the access request to be rejected despite actions indicated in the access request being authorized. Further, an independent simulation environment may be utilized for testing access control policy evaluation.

Abstract: Systems and methods for the dynamic selection of IP address in email platforms, and the synchronization of hostnames and IP addresses in such platforms, are disclosed.