Abstract: A room-level sound-event sensor is used to initiate the location process whenever it is likely that a person has entered or left the room. A room-level sound-event sensor is defined as an electronic sensing device that can determine whether a sound event occurs in one room, independently of what is happening in any adjacent room. In one embodiment of the invention, a room-level sound-event sensor may be a microphone. The sensed room-level sound event is the transition from a room being silent to a room being occupied by people speaking.

Abstract: A room-level event sensor is used to initiate the location process whenever it is likely that a person has entered or left the room. A room-level event sensor is defined as an electronic sensing device that can determine whether an event occurs in one room, independently of what is happening in any adjacent room. In one embodiment of the invention, a room-level event sensor may be a door-position sensor, and the room-level event it senses is the opening or closing of a door. It is very likely that a patient or caregiver can enter or leave a room only when the door-position sensor perceives an open door. In another embodiment, a room-level event sensor may be a microphone. The sensed room-level event is the transition from a room being silent to a room being occupied by people speaking.

Abstract: A real-time location system (RTLS) having tags, bridges, bay-level event sensors and a location engine for use in determining the bay location of tags, To determine which bay a tag is in, bay-level event sensors sense motion events in the bay, transmit the motion event reports to a location engine, and/or tags. Tags contain an accelerometer, to sense motion of the tags. A series of location-engine steps estimates the bay-level-location of the tags based on a combination of received signal-strength analysis, and a comparison of tag-motion status to the perceived motion events in a bay. The analysis of tag-motion status and motion-in-bay events produces a better estimate of bay-level location of the tag than a received-signal-strength estimate can produce alone.

Abstract: A portable-device real-time locating system (RTLS) having portable devices and in-room radio-transmitting beacons. To determine which room a portable device is in, beacons broadcast radio transmissions containing motion-status information about recent history of perceived motion in a room as determined from a motion sensor in the beacon. Portable devices calculate received signal strength indications (RSSI) from nearby beacons, motion-in-room status sensed and reported by those beacons, plus their own motion status based on a portable-device-based accelerometer. A series of portable-device steps estimates the room-location of the portable based on a combination of RSSI analysis, and a comparison of portable-device-motion history to the perceived and recorded motion-status in a room. The analysis of portable-device-motion history and motion-in-room status produces a better estimate of room-level location of the portable device than an RSSI estimate can produce alone.

Abstract: A real-time location system (RTLS) uses transmitting and listening tags, bridges, and beacons. The fixed beacons broadcast BLE advertisements containing motion-status information about recent history of perceived motion in a room as determined from a motion sensor in the beacon. The bridges forward the beacon's received advertisements to a location engine, which records timestamps of motion events seen by each beacon in each room. One or more tags then report their own motion status based on a tag-based accelerometer. The system utilizes a series of location-engine steps, to estimate the room-location of the tags based on a specific combination of RSSI analysis, and a comparison of tag-motion history to the perceived and recorded motion-status in a room. This analysis of tag-motion history and motion-in-room status produces a better estimate of room-level location of the tag than can be estimated by simple proximity or multi-lateration using radio signal strengths.

Abstract: An energy harvesting tag for use in a real time location system (RTLS) includes a battery powered transceiver where a photocell and energy storage device are used to provide power to the transceiver and a microprocessor when the battery is dead or inoperative.

Abstract: An energy harvesting tag for use in a real time location system (RTLS) includes a battery powered transceiver where a photocell and energy storage device are used to provide power to the transceiver and a microprocessor when the battery is dead or inoperative.

Abstract: The present invention relates generally to a real-time location system (RTLS) having tags, bridges, bay-level event sensors and a location engine. To determine which bay a tag is in, bay-level event sensors sense motion events in the bay, transmit the motion event reports to a location engine, and/or tags. Tags contain an accelerometer, to sense motion of the tags. A series of location-engine steps estimates the bay-level-location of the tags based on a combination of received signal-strength analysis, and a comparison of tag-motion status to the perceived motion events in a bay. The analysis of tag-motion status and motion-in-bay events produces a better estimate of bay-level location of the tag than a received-signal-strength estimate can produce alone.

Abstract: A portable-device real-time locating system (RTLS) having portable devices and in-room radio-transmitting beacons. To determine which room a portable device is in, beacons broadcast radio transmissions containing motion-status information about recent history of perceived motion in a room as determined from a motion sensor in the beacon. Portable devices calculate received signal strength indications (RSSI) from nearby beacons, motion-in-room status sensed and reported by those beacons, plus their own motion status based on a portable-device-based accelerometer. A series of portable-device steps estimates the room-location of the portable based on a combination of RSSI analysis, and a comparison of portable-device-motion history to the perceived and recorded motion-status in a room. The analysis of portable-device-motion history and motion-in-room status produces a better estimate of room-level location of the portable device than an RSSI estimate can produce alone.

Abstract: A real-time location system (RTLS) uses transmitting and listening tags, bridges, and beacons. The fixed beacons broadcast BLE advertisements containing motion-status information about recent history of perceived motion in. a room as determined from a motion sensor in the beacon. The bridges forward the beacon's received advertisements to a location engine, which records timestamps of motion events seen by each beacon in each room. One or more tags then report their own motion status based on a tag-based accelerometer. The system utilizes a series of location-engine steps, to estimate the room-location of the tags based on a specific combination of RSSI analysis, and a comparison of tag-motion history to the perceived arid recorded motion-status in a room. This analysis of tag-motion history and motion-in-room status produces a better estimate of room-level location of the tag than can be estimated by simple proximity or multi-lateration using radio signal strengths.

Abstract: The present invention relates generally to a real-time location system (RTLS) and more particularly to a Bluetooth Low Energy (BLE) RTLS having tags, bridges, and beacons. To determine which room a tag is in, beacons broadcast BLE advertisements containing motion-status information about recent history of perceived motion in a room as determined from a motion sensor in the beacon. Tags report received signal strength indications (RSSI) from nearby beacons, motion-in-room status sensed and reported by those beacons, plus their own motion status based on a tag-based accelerometer. A series of location-engine steps estimates the room-location of the tags based on a combination of RSSI analysis, and a comparison of tag-motion history to the perceived and recorded motion-status in a room. The analysis of tag-motion history and motion-in-room status produces a better estimate of room-level location of the tag than an RSSI estimate can produce alone.

Abstract: A real-time location system (RTLS) uses Bluetooth Low Energy (BLE) transmitting tags, bridges, and beacons. The fixed beacons broadcast BLE advertisements containing motion-status information about recent history of perceived motion in a room as determined from a motion sensor in the beacon. The bridges forward the beacon's received advertisements to a location engine, which records timestamps of motion events seen by each beacon in each room. One or more simple transmitting tags then report their own motion status based on a tag-based accelerometer. The system utilizes a series of location-engine steps, to estimate the room-location of the tags based on a specific combination of RSSI analysis, and a comparison of tag-motion history to the perceived and recorded motion-status in a room. This analysis of tag-motion history and motion-in-room status produces a better estimate of room-level location of the tag than can be estimated by simple proximity or multi-lateration using radio signal strengths.

Abstract: The present invention provides transgenic, large non-human animal models of cancer, as well as methods of using such animal models in the identification and characterization of therapies for cancer.

Abstract: A real-time locating system (RTLS) for use in tracking assets and people includes tag, beacon and bridge components, where the tag contains a Bluetooth low energy (BLE) transceiver and a microprocessor for operating the transceiver. The tag is powered by a battery that depletes. A photocell is connected to an energy storage device. A capacitor is connected to the energy storage device such that the photocell charges the energy storage device so the capacitor can power the microprocessor and BLE transceiver for performing limited tasks upon battery depletion. The tag also includes a speaker for providing an audible sound to locate an out-of-sight tag and an accelerometer for detecting tag movement. The bridge is able to temporarily toggle each tag into a connectable-advertising state for connection to a smart device. The beacon and bridge are able to self-report location changes estimated with the use of onboard filters.

Abstract: The present invention provides transgenic, large non-human animal models of Ataxia-Telangiectasia, as well as methods of using such animal models in the identification and characterization of therapies for Ataxia-Telangiectasia.

Abstract: The present invention provides transgenic, large non-human animal models of cancer, as well as methods of using such animal models in the identification and characterization of therapies for cancer.

Abstract: The present invention provides a composition and an improved single dose vaccine against E. rhusiopathiae and an improved single dose vaccine against E. rhusiopathiae and H. parasuis which provides one or more of the following: 1) confers effective immunity against E. rhusiopathiae and/or H. parasuis; 2) decreases the risk of developing clinical signs of E. rhusiopathiae and/or H. parasuis infection; 3) induces an immune response against E. rhusiopathiae and/or H. parasuis; and 4) has a DOI against E. rhusiopathiae and/or H. parasuis of at least four months. The composition or E. rhusiopathiae vaccine as well as the combined E. rhusiopathiae-H. parasuis composition or vaccine each includes a bacterial component of inactivated E. rhusiopathiae bacteria and a suitable adjuvant. The combined E. rhusiopathiae-H. parasuis composition or vaccine further includes an amount of H. parasuis antigen. The vaccines can be administered to animals in any conventional manner.