Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compound of formula (I) to treat necroptosis and/or inhibit RIP1 and/or MLKL.

Abstract: A video is generated from an audio file by transcribing the audio file into texts and breaking the audio file into one or more segments or shots used as scenes. A media piece is then matched to each shot; the media pieces are properly contextualized based on the text or attributes of the audio associated with the shot, the overall script or theme, an intended audience, or other factors. The resulting video is then created by stitching the media pieces together.

Abstract: An ETFE film that has a haze value of 2% or less, and preferably 1% or less, which advantageously may have a thickness greater than 150 pm, and preferably In the range of 200 pm to 300 pm, A film of ETFE, as received from the manufacturer, is stretched under special processing conditions to produce a processed (or final) film having an area stretch factor (Ax) greater than about 1.6. Ax —Initial film thickness/film thickness after stretching. However, it is important that the initial film thickness has a starting thickness of at least 400 pm, and preferably at least 500 pm. Processing conditions Include, in some embodiments, pre-beating and heating during stretching, and post-stretching annealing If the film is stretched in a 2.5×1 or a 4×1 ratio, at a processing temperature in THV range of 130° C. to 150° C., the haze of the resulting film can be reliably brought down to less than 2%. We have also found that this low haze value is not dependent on whether the larger stretch {e.g.

Abstract: In some examples, a cloud-based management system receives information identifying electronic devices to be onboarded for cloud-based management by the cloud-based management system, receives, from a first electronic device, a request to establish a secure connection between the cloud-based management system and the first electronic device, and receives, from the first electronic device, a certificate. The cloud-based management system confirms, based on information in the certificate and the information identifying the electronic devices to be onboarded for cloud-based management, that the cloud-based management system is to perform the cloud-based management of the first electronic device over the secure connection.

Abstract: A hair conditioner composition comprising: a. an aqueous carrier; b. from about 1 wt % to about 12 wt % of BVE; and c. from about 1 wt % to about 12 wt % of at least two fatty alcohols.

Abstract: A link chain cleaning and lubricating device, and lubricants for use therein.

Abstract: A method of operating a device, which includes providing a user interface with a display artifact; in response to an indication a user selected to copy the display artifact, storing multiple levels of detail of the display artifact; allowing the user to paste a selected level of detail by steps of: in response to an indication a user selected an input field and a paste command, displaying a plurality of paste options for pasting the display artifact into the input field, wherein the plurality of paste options each have a unique level of detail for representing the display artifact; allowing the user to select from the plurality of paste options; and in response to an indication a user selected a paste option from the plurality of paste options, pasting the display artifact with a level of detail associated with the selected paste option into the input filed.

Abstract: In some examples, a method comprises determining, at an electronic device having a first component of a first component type, a unique identifier associated with the first component. In some examples, in accordance with a determination that the unique identifier does not match the expected identifier of the component of the first component type in the electronic device, determining that the first component associated with the unique identifier satisfies one or more eligibility criteria. In some examples, in accordance with the determination that the first component associated with the unique identifier satisfies the one or more eligibility criteria, authenticating an association of the first component with the electronic device, including updating an installation counter associated with the first component, and updating the expected identifier for the component of the first type based on the unique identifier of the first component.

Abstract: A self-aligning support incorporates a support attachment fitting and a rotatable pin assembly having a primary load pin coupling the support attachment fitting to an attachment support, and inboard and outboard attachment claws engaged to end portions of the primary load pin. The rotatable pin assembly is configured to rotate relative to the support attachment fitting. At least one fuse pin extends through the primary load pin to limit translation of the primary load pin relative to the inboard and outboard claws.

Abstract: An improved perforating gun with novel endplates is disclosed along with a corresponding method of assembly. The endplate may include a base with first end separated from a second end separated by a curved sidewall centered around a longitudinal axis and a set of tube tabs flexibly coupled to the base and extending from the second end. The endplate may include a carrier tab with an integrated alignment pin. Selected embodiments may also include a zero-tension connector with a sliding contact mounted within a cavity of a housing, a through-wire connected to the sliding contact. The novel endplate reduces the cost and complexity of manufacture and installation.

Abstract: An annular tube (or other shape) of elastomeric cellular material comprising elastomeric closed cells having gas infused therein is supported by structures protruding from the bottom surface of a suction stabilizer's head and/or by structures within the interior volume of the annular body of the suction stabilizer, preferably with spacing between the outer diameter of the annular tube of the cellular material and the inner walls of the suction stabilizer body. The gas-infused closed cell material may thus be employed in new suction stabilizer or pulsation dampener or to retrofit existing suction stabilizers or pulsation dampeners designed for a gas-filled bladder.

Abstract: A portable carrying apparatus configured to selectively attach a cargo load to one or more attachment points and enable a user to balance and carry the attached cargo load on one or both of the user’s shoulders. A portable carrying apparatus of the present disclosure may include an elongated body comprising a first plurality of receiving portions disposed on a first arm portion and a second plurality of receiving portions disposed on a second arm portion. One or more attachment connectors may be selective interfaced with the first plurality of receiving portions. A user may selectively attach one or more cargo loads to the one or more attachment connectors in order to carry the cargo loads on the shoulder(s) of the user via the portable carrying apparatus.

Abstract: A semiconductor burn-in oven includes a housing including a burn-in chamber and an opening to the burn-in chamber surrounded by a front face, a heating device, testing circuitry, a door and a sealing mechanism. The door has an open position, in which the burn-in chamber is accessible through the opening, and a closed position, in which the door covers the opening. The sealing mechanism is configured to form a seal around the opening between an interior side of the door and the front face when the door is in the closed position. The sealing mechanism includes at least one sealing member having a recessed position, in which a gap extends between the front face and the interior side of the door, and a sealing position, in which the at least one sealing member closes the gap and forms the seal.

Abstract: A pool cover assembly includes a first encapsulation member defining a first side of a pool cover encapsulation, the first encapsulation member comprising a first mating feature. The pool cover assembly further includes a second encapsulation member defining a second side of the pool cover encapsulation, the second encapsulation member comprising a second mating feature. And the pool cover assembly further includes a corner endcap member comprising a third mating feature and a fourth mating feature. The first encapsulation member is coupleable to the corner endcap by the first mating feature and the third mating feature, and the second encapsulation member is coupleable to the corner endcap by the second mating feature and the fourth mating feature. The corner endcap member couples with the first encapsulation member and the second encapsulation member to form a corner of the pool cover encapsulation.

Abstract: A portable carrying apparatus comprises a plurality of segments that mateably couple together to form an elongated carrying apparatus. Each of the plurality of segments may be selectively de-coupled from each other to enable a user to break down the apparatus and stack each segment for storage when not in use. In accordance with certain aspects of the present disclosure, the apparatus may have a first end (e.g., a proximal end) and a second end (e.g., a distal end) that are configured to receive/carry one or more cargo loads (e.g., a connected hook, strap, bag handle and the like). A user of the apparatus may selectively attach one or more cargo loads to the first end and/or second end of the apparatus and balance the apparatus on one or both of the user's shoulders to carry/transport the one or more cargo loads more easily to and from a desired destination.

Abstract: This specification describes membrane based filtration and softening systems and methods. A system has a microfiltration or ultrafiltration (MF/UF) membrane unit upstream of a nanofiltration or reverse osmosis (NF/RO) membrane unit, optionally with no intermediate tank. In some cases, the system and method may be used with feed water provided at municipal line pressure to the membranes. NF/RO permeate is collected in a tank and then pumped to a header. Treated water may be drawn from the header for use or recycled to the system, for example to backwash or flush one or both of the membrane units. In a combined process, NF/RO permeate flushes the feed side of the NF/RO unit and then backwashes the MF/UF unit. In another process, the MF/UF unit and NF/RO unit are filled with NF/RO permeate before being placed in a standby mode.

Abstract: Embodiments optimize display ordering of reservable hotel room choices for a hotel. Embodiments receive a trained prediction demand model for the hotel, the trained prediction model including estimated coefficients, and receive a total inventory of hotel rooms for the hotel. Embodiments determine optimal Lagrangian coefficients from the estimated coefficients using a first iterative gradient search and determine optimized prices per customer based on the estimated coefficients and the optimal Lagrangian coefficients using a second iterative gradient search. Embodiments determine an offer order optimization per customer based on the optimal Lagrangian coefficients and using linear programming. Embodiments receive a request for a hotel room from a first customer, the request including one or more attributes. Based on the one or more attributes and the optimized prices per customer and the offer order optimization per customer, embodiments display an optimized ordered list of hotel room choices.

Abstract: A suture and button construct, having an oblong button defining at least a first aperture and a second aperture; a suture length, including a braid defining a lumen and having a middle section and two end sections, each extending through a button aperture and both terminating in an end. Both ends have a needle attached. Also, two shuttles are engaged to the suture length, each having a free end and a loop end, terminating in a loop. Each shuttle enters the lumen in the middle section and extend through an aperture, while in the lumen and exit on the opposite button side from the middle section, so that both shuttle loops are available outside the lumen, to pull a suture end through the lumen and a button aperture.

Abstract: A vehicle automated unloading system may include a fill model and an unloading controller. The fill model is a model of a fill characteristic of a container as a function of variables comprising material unloading times, material unloading rates and material unloading locations. The unloading controller is to (a) determine a current model-based fill characteristic of the container using the dynamic fill model and (b) output control signals to adjust at least one of a material unloading time, a material unloading rate and a material unloading location based upon the current model-based fill characteristic of the container.

Abstract: A system and method for determining performance of an engine is provided. The system includes two or more sensors configured in operable arrangement at two or more respective positions at a flowpath. The system includes one or more computing devices configured to perform operations, the operations include acquiring, via the two or more sensors, parameter sets each corresponding to two or more engine conditions different from one another, wherein each parameter set indicates a health condition at a respective location at the engine; comparing, via the computing device, the parameter sets to determine the respective health condition corresponding to the respective location at the engine; and generating, via the computing device, a health condition prediction based on the compared parameter sets.