Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: Disclosed are various embodiments for identifying fault injection impact zones. A test for an application can be received from a test service. An application schema can then be created that represents the systems or services that are involved in the execution of the application. Applications with a similar application schema are then identified using a first machine-learning model. A subset of the plurality of applications that have experienced a similar test are then identified with a second machine-learning model. Log files associated with each of the subset of applications are then analyzed to identify errors that occurred during the similar test. Each of the identified errors are then provided to the test service in response to receipt of the test.

Abstract: Disclosed is a toilet module having a toilet bowl and which also has a toilet bowl support mechanism. The toilet bowel support mechanism allows the toilet bowl to be moved to a position in which the person using the toilet to adopt more of a squatting posture when cleansing their bowels. The toilet bowl support mechanism can move the toilet bowl to and between a first position and a second position, the first position is characterised in that the front end of the toilet bowl is lower than the aft end of the toilet bowl, and the second position is characterised in that the front end of the toilet bowl is above the aft end of the toilet bowl. The first position makes it easier for folk with limited mobility to sit on the toilet, and the second position allows the seated person to adopt a squatting posture.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: A subsea assembly can include a pressure control device having an annular seal configured to seal off an annulus formed between an outer housing and a tubular string, a connector, and a guide configured to guide the tubular string into an internal flow passage extending through the subsea assembly, the pressure control device being connected between the connector and the guide. A method can include assembling a subsea assembly with a pressure control device and a connector, the pressure control device including an outer housing and an annular seal, lowering the subsea assembly through water from a rig to a subsea wellhead installation, connecting the subsea assembly to the subsea wellhead installation, and positioning a tubular string in the subsea assembly, so that the annular seal seals against an external surface of the tubular string, the tubular string being exposed to the water between the rig and the subsea assembly.

Abstract: The present disclosure features methods and related compositions that, inter alia, modulate the mitochondrial lipid shunt pathway, including the modulating the cellular mechanisms by which lipids (e.g., fatty acids) are transported between the mitochondria, stress granules, and lipid droplets.

Abstract: An apparatus for an improved board game combining the advantages of both traditional and electronic games. The apparatus includes a game board and a plurality of game pieces, wherein the apparatus is configured to detect the identity and location of a given game piece on the game board; and a server communicable with the game board and configured to receive information on the identity and location of the game pieces relative to the game board, and, if appropriate, send to the game board a display instruction, wherein the game board is configured to, in response to the display instruction, electronically display a game progress indicator.

Abstract: An automated game board apparatus configured to, upon receiving a command from a player, determine a path from an origin segment to a destination segment and automatically move a selected game piece from the origin segment to the destination segment; wherein, if one or more intermediate segments along the path are occupied by other game pieces, the selected piece is moved along the boundaries of the occupied segment; and wherein, if the destination segment is occupied, the apparatus is further configured to automatically replace the existing game piece with the selected game piece by moving the existing game piece to substantially the boundary of the destination segment and moving the selected game piece to substantially the centre of the destination segment. In preferred embodiments, the invention utilizes electromagnets, correlated electromagnet array technology (CEAT), and/or correlated magnets.

Abstract: A method of generating multiple channels of optical pulses comprises: providing a continuous wave optical input having an optical power; dividing the optical power of the optical input into equal consecutive slices in the time domain; and allocating the consecutive slices sequentially to two or more optical outputs such that each output forms a channel of optical pulses of equal pulse repetition rate shifted in time relative to the or each other channel.

Abstract: An optical modulator. The optical modulator comprising: a micro-ring resonator; and a bus waveguide, including an input waveguide region, an output waveguide region, and a coupling waveguide region optically coupled to the micro-ring resonator and located between the input waveguide region and the output waveguide region. The micro-ring resonator includes a modulation region, the modulation region being formed of a silicon portion and a III-V semiconductor portion separated by a crystalline rare earth oxide dielectric layer.

Abstract: Disclosed is a toilet module having a toilet bowl and which also has a toilet bowl support mechanism. The toilet bowel support mechanism allows the toilet bowl to be moved to a position in which the person using the toilet to adopt more of a squatting posture when cleansing their bowels. The toilet bowl support mechanism can move the toilet bowl to and between a first position and a second position, the first position is characterised in that the front end of the toilet bowl is lower than the aft end of the toilet bowl, and the second position is characterised in that the front end of the toilet bowl is above the aft end of the toilet bowl. The first position makes it easier for folk with limited mobility to sit on the toilet, and the second position allows the seated person to adopt a squatting posture.

Abstract: An optical modulation system comprises a signal source configured to generate an amplitude modulated electrical signal having a bandwidth and divided into frequency components comprising at least a first frequency component covering a first portion of the bandwidth and a second frequency component covering a second portion of the bandwidth; and an electro-optic modulator for receiving an input optical signal, the modulator having a first optical path and a second optical path, the input optical signal being divided between the first optical path and the second optical path and recombined after propagation along the first optical path and the second optical path to produce an output optical signal, and at least one of the first optical path and the second optical path comprising a phase shifter comprising a pair of electrodes in which each electrode is configured to receive a driving signal; wherein the or each phase shifter is coupled to the signal source to receive at least one of said frequency components a

Abstract: An optical modulation system comprises a signal source configured to generate an amplitude modulated electrical signal having a bandwidth and divided into frequency components comprising at least a first frequency component covering a first portion of the bandwidth and a second frequency component covering a second portion of the bandwidth; and an electro-optic modulator for receiving an input optical signal, the modulator having a first optical path and a second optical path, the input optical signal being divided between the first optical path and the second optical path and recombined after propagation along the first optical path and the second optical path to produce an output optical signal, and at least one of the first optical path and the second optical path comprising a phase shifter comprising a pair of electrodes in which each electrode is configured to receive a driving signal; wherein the or each phase shifter is coupled to the signal source to receive at least one of said frequency components a

Abstract: The disclosure provides a method of forming an erasable optical coupler in a photonic device comprising a conventional optical waveguide formed in a crystalline wafer. The method comprises selectively implanting ions in a localized region of the wafer material adjacent to the conventional waveguide of the photonic device, to cause modification of the crystal lattice structure of, and a change in refractive index in, the ion implanted region of the wafer material to thereby form an ion implanted waveguide optically coupled to the adjacent conventional waveguide to couple light out therefrom, or in thereto. The crystalline wafer material and ion implanted waveguide are such that the crystal lattice structure or composition can be modified to adjust or remove the optical coupling with the conventional waveguide by further modification of the refractive index in the ion implanted region.

Abstract: A discrete wavelength tunable laser capable of switching between a plurality of lasing channels of different wavelengths, the tunable laser comprising: a semiconductor optical amplifier (SOA); a wavelength demultiplexer (Demux), having a Demux input which receives the output from the SOA, and a plurality of Demux outputs, each Demux output defining a different spatial path for a respective lasing channel; each of the respective lasing channels being within the bandwidth of the SOA; a reflector located within each spatial path for reflecting light of the respective lasing channel; and a lasing suppression mechanism located within each lasing channel; wherein one or more desired lasing channels are selected by application of the lasing suppression mechanism in each spatial path other than the one or more spatial paths corresponding to the one or more desired lasing channels.

Abstract: A method of operating an optical modulator. The optical modulator having: a rib waveguide which includes a junction which is either a PIN or PN junction, the junction having a breakdown voltage. The method comprising: applying a reverse bias to the junction, so as to operate the optical modulator around the breakdown voltage of the junction; operating the modulator in an avalanche multiplication and/or band-to-band tunnelling mode by increasing the reverse bias past the breakdown voltage.

Abstract: A method of trimming the refractive index of material forming at least part of one or more structures integrated in one or more pre-fabricated devices, the method comprising: implanting one or more first regions of material of one or more pre-fabricated devices, encompassing at least partially one or more device structures, with ions to alter the crystal form of the material within the one or more first regions and change the refractive index of the material within the one or more first regions; and heat treating one or more second regions of material of the one or more devices, encompassing at least partially the one or more first regions, to alter the crystal form of the material within the one or more first regions encompassed by the one or more second regions and change the refractive index thereof, thereby trimming the refractive index of the material of at least part of the one or more device structures, such that the one or more device structures provide one or more predetermined device outputs.

Abstract: The disclosure provides a method of forming an erasable optical coupler in a photonic device comprising a conventional optical waveguide formed in a crystalline wafer. The method comprises selectively implanting ions in a localized region of the wafer material adjacent to the conventional waveguide of the photonic device, to cause modification of the crystal lattice structure of, and a change in refractive index in, the ion implanted region of the wafer material to thereby form an ion implanted waveguide optically coupled to the adjacent conventional waveguide to couple light out therefrom, or in thereto. The crystalline wafer material and ion implanted waveguide are such that the crystal lattice structure or composition can be modified to adjust or remove the optical coupling with the conventional waveguide by further modification of the refractive index in the ion implanted region.

Abstract: A method of operating an optical modulator. The optical modulator having: a rib waveguide which includes a junction which is either a PIN or PN junction, the junction having a breakdown voltage. The method comprising: applying a reverse bias to the junction, so as to operate the optical modulator around the breakdown voltage of the junction; operating the modulator in an avalanche multiplication and/or band-to-band tunnelling mode by increasing the reverse bias past the breakdown voltage.

Abstract: A discrete wavelength tunable laser capable of switching between a plurality of lasing channels of different wavelengths, the tunable laser comprising: a semiconductor optical amplifier (SOA); a wavelength demultiplexer (Demux), having a Demux input which receives the output from the SOA, and a plurality of Demux outputs, each Demux output defining a different spatial path for a respective lasing channel; each of the respective lasing channels being within the bandwidth of the SOA; a reflector located within each spatial path for reflecting light of the respective lasing channel; and a lasing suppression mechanism located within each lasing channel; wherein one or more desired lasing channels are selected by application of the lasing suppression mechanism in each spatial path other than the one or more spatial paths corresponding to the one or more desired lasing channels.