Patents by Inventor John A. Thomson

John A. Thomson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND COMPOSITIONS FOR MODULATING LIPID METABOLISM
    Publication number: 20240207270
    Abstract: The present disclosure features methods and related compositions that, inter alia, modulate the mitochondrial lipid shunt pathway, including the modulating the cellular mechanisms by which lipids (e.g., fatty acids) are transported between the mitochondria, stress granules, and lipid droplets.
    Type: Application
    Filed: March 30, 2022
    Publication date: June 27, 2024
    Inventors: Patrick Connelly, Daniel Kaganovich, John A. Thomson
  • Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
    Publication number: 20020042046
    Abstract: The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.
    Type: Application
    Filed: September 14, 2001
    Publication date: April 11, 2002
    Applicant: Vertex Pharmaceuticals, Incorporated
    Inventors: Joseph L. Kim, Kurt A. Morgenstern, Chao Lin, Ted Fox, John A. Thomson
  • Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
    Patent number: 6303287
    Abstract: The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: October 16, 2001
    Assignee: Vertex Pharmaceuticals, Incorporated
    Inventors: Joseph L. Kim, Kurt A. Morgenstern, Chao Lin, Ted Fox, John A. Thomson
  • Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
    Patent number: 6153579
    Abstract: The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.
    Type: Grant
    Filed: October 18, 1996
    Date of Patent: November 28, 2000
    Assignee: Vertex Pharmaceuticals, Incorporated
    Inventors: Joseph L. Kim, Kurt A. Morgenstern, Chao Lin, Ted Fox, John A. Thomson
  • Chemical prevention or reversal of cataract by phase separation inhibitors
    Patent number: 5290813
    Abstract: The present invention relates to methods and pharmaceutical reagents for decreasing the phase separation temperature and inhibiting the formation of high molecular weight aggregates in eye lenses, thereby inhibiting or reversing cataract formation.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: March 1, 1994
    Assignee: Massachusetts Institute of Technology
    Inventors: John I. Clark, Geroge B. Benedek, Roelant J. Siezen, John A. Thomson, Simon H. Friedman
  • Chemical prevention or reversal of cataract by phase separation inhibitors
    Patent number: 5091421
    Abstract: The present invention relates to methods and pharmaceutical reagents for decreasing the phase separation temperature and inhibiting the formation of high molecular weight aggregates in eye lenses, thereby inhibiting or reversing cataract formation.
    Type: Grant
    Filed: December 15, 1989
    Date of Patent: February 25, 1992
    Assignee: Massachusetts Institute of Technology
    Inventors: John I. Clark, George B. Benedek, Roelant J. Siezen, John A. Thomson, Simon H. Friedman
  • Liquid storage and measurement system
    Patent number: 4427132
    Abstract: A liquid storage and measurement system particularly applicable to the volumetric measurement of siquid hydrocarbon fuel and to the dispensing of the fuel via a fuel dispensing unit, includes a liquid measurement/storage vessel of known dimensions arranged to be partially filled with liquid, e.g.
    Type: Grant
    Filed: September 15, 1981
    Date of Patent: January 24, 1984
    Assignee: Avery-Hardoll Limited
    Inventor: John A. Thomson