Abstract: The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: A head-mounted display (HMD) includes various features that allow for customizing the HMD to different users. The HMD may include an interpupillary distance (IPD) adjustment mechanism that includes a double biasing assembly for smooth, controlled adjustment of the spacing between lens tubes. The HMD may include a field of view (FOV) adjustment mechanism that includes first and second gear assemblies connected via a connecting rod to allow uniform adjustment of the spacing between the lenses and the user's face. The HMD may further include a swappable face gasket, a swappable visor, a removable head strap, and a modular accessory compartment for further customizations to the HMD. The HMD may further include inconspicuous spectrum-transmissive windows that are made with a spectrum-transmissive base material for the HMD housing that is coated with a spectrum-opaque material, and the spectrum-opaque material is selectively removed to create the spectrum-transmissive windows.

Abstract: The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: A workpiece handling module including a first housing member and a second housing member pivotally movable relative to the first member forming a housing having an access side and a second side opposite the access side and side walls, a first portion of the side walls is carried by the first member and a second portion of the side walls is carried by the second member, and at least one of the first and second housing members includes at least one sealable opening for allowing ingress and egress of workpieces to and from an interior chamber formed by the first and second housing members in a closed configuration, and the second portion of the side walls adjacent the access side and carried by the second member is greater than the first portion of the side walls adjacent the access side and carried by the first member.

Abstract: The instant disclosure provides antibodies that specifically bind to T-cell immunoreceptor with Ig and ITIM domains (TIGIT) (e.g., human TIGIT) and antagonize TIGIT function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: An ignition control system for an internal combustion engine has a coil connector for connecting to an ignition coil, a processor coupled to the coil connector, and a memory coupled to the processor. The memory contains instructions for the processor to, in communication with the ignition coil, achieve and maintain a target spark duration by dynamically controlling a coil dwell set-point of the ignition coil. The processor energizes the ignition coil during a first ignition sequence based on the coil dwell set-point, directly measure spark duration of the first ignition sequence by monitoring a voltage reflection on a primary side of the ignition coil, adjust the coil dwell set-point for a second ignition sequence based on the target spark duration and the measured spark duration, and energizes the ignition coil during the second ignition sequence based on the adjusted coil dwell set-point.

Abstract: The instant disclosure provides antibodies that specifically bind to TIM-3 (e.g., human TIM-3) and antagonize TIM-3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.

Abstract: There is provided a magnetic clamping device (10) for magnetically clamping to a magnetically attracted material (30). The device comprises at least one permanent clamping magnet (14, 44) for magnetically clamping to the magnetically attracted material wherein the magnet is movable relative to the magnetically attracted material from a position remote from the magnetically attracted material to a clamping position for the clamping of the material by the magnet. The device also includes damping means (22, 24) for damping the movement of the clamping magnet to the clamping position. The damping means biases the clamping magnet away from the magnetically attracted material to assist release of the clamping magnet from the magnetically attracted material.

Abstract: A technique for generating a web site in accordance with received data entry by: determining at least one characteristic of at least one web site dimension of the web site based on the data entry; generating a multi-dimensional description of the web site based on the determined characteristics; retrieving web site data according to the generated multi-dimensional description of the web site; and generating the web site based upon the generated multi-dimensional description of the web site and the retrieved web site data. The web site data includes dynamic content data from an external data source, and the data entry may include a designation of such an external data source.

Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.

Abstract: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.

Abstract: A workpiece handling module including a first housing member and a second housing member pivotally movable relative to the first member forming a housing having an access side and a second side opposite the access side and side walls, a first portion of the side walls is carried by the first member and a second portion of the side walls is carried by the second member, and at least one of the first and second housing members includes at least one sealable opening for allowing ingress and egress of workpieces to and from an interior chamber formed by the first and second housing members in a closed configuration, and the second portion of the side walls adjacent the access side and carried by the second member is greater than the first portion of the side walls adjacent the access side and carried by the first member.

Abstract: The present invention relates to a process for the processing of perfluoropolymer materials, and to the use of the resultant products in different potential applications, such as in the medical device field.