Abstract: Provided herein are recombinant CTLA-4 binding proteins, which are, inter alia, useful for the treatment of cancer. The recombinant proteins provided herein are, inter alia, capable of binding CTLA-4 proteins on a tumor cell. In a first aspect, there is provided a recombinant CTLA-4 binding protein including (i) a CTLA-4 binding domain; (ii) a CTLA-4 binding domain masking peptide; and (iii) a cleavable peptide linker connecting the CTLA-4 binding domain masking peptide to the CTLA-4 binding domain. In another aspect, there is provided a dimerizing domain covalently attached to the CTLA-4 binding domain, wherein the binding protein domains are bound together.

Abstract: The present disclosure sets forth a motion sensing outdoor security light with the flexibility of being mounted to either a wall structure or to an eave or ceiling structure. An adjustable spherical motion sensor housing may be provided with the rotationally adjustable outdoor security light, allowing easy adjustment of motion detection ranges under different mounting schemes without comprising the aesthetic design of the light. The adjustable spherical motion sensor housing may also provide an enlarged horizontal field of view for better performance. Sensitivity of a motion sensor may be adjusted via a control circuit based on adjustment of the spherical motion sensor housing.

Abstract: As a farming machine travels through a field of plants, the farming machine operates in a normal operational state to perform one or more farming operations. The farming machine detects an operational failure of a component of the farming machine using measurements obtained from one or more sensors coupled to and monitoring the farming machine. The operational failure of the component impacts performance of a first farming operation of the farming operations. The farming machine configures the farming machine to operate in a remedial operational state. In the remedial operational state, the farming machine diagnoses the operational failure of the component using the obtained measurements. In the remedial operational state, the farming machine selects a solution operation to address the operational failure of the component based on the diagnosis. The farming machine performs the determined solution operation.

Abstract: A system has an axial field rotary energy device with a housing, an axis and a rotor with a shaft, bearings, rotor disks and permanent magnets. A printed circuit board (PCB) stator is between the rotor disks to define an air gap on each side thereof. A variable frequency drive (VFD) assembly has a VFD housing and first pads coupled to inductors to facilitate heat removal from the inductors. A concave cradle is coupled to a ferromagnetic core and has a same contour as an outer surface of the ferromagnetic core. A second pad is coupled to a rectifier module. A third pad is coupled to switching devices and has pins to align the switching devices with the third pad. Standoffs are coupled to the VFD housing to support a first printed circuit board assembly (PCBA). A second PCBA is mounted to a shield plate above the first PCBA.

Abstract: A rotary molding system configured to mold food products includes a fill plate through which food product is configured to pass, a cylindrical rotatable drum having mold cavities into which the food product is configured to be deposited, and a platen mounted within the drum. The platen has a plurality of passageways configured to be in communication with the mold cavities. Drum roller supports and rollers are provided on the platen. The extends partially outwardly from the platen and are in contact with the drum.

Abstract: A smoking article may include a cigarette incorporated within an electrically powered aerosol generating device that acts as a holder for that cigarette. The smoking article possesses at least one form of tobacco. The smoking article also possesses a mouth-end piece that is used by the smoker to inhale components of tobacco that are generated by the action of heat upon components of the cigarette. A representative smoking article possesses an outer housing incorporating a source of electrical power (e.g., a battery), a sensing mechanism for powering the device at least during periods of draw, and a heating device (e.g., at least one electrical resistance heating element) for forming a thermally generated aerosol that incorporates components of tobacco. During use, the cigarette is positioned within the device, and after use, the used cigarette is removed from the device and replaced with another cigarette.

Abstract: The disclosure relates to improvements in methods for efficient editing of two or more endogenous tomato genes by insertion of one or more single stranded DNA donor molecules that are not homologous to the insertion sites in the tomato genome.

Abstract: Systems, methods, and computer-readable storage media for aggregating media (and commentary on that media) into a topology. To do so, the system receives first content (and associated metadata) as well as second content (and associated metadata). The system then generates a topology based on a relationship between the first content and the second content, where the topology has a number of dimensions based on the metadata of the different pieces of content. The system then compares the topology and the metadata to previously stored topologies and/or metadata and, based on that comparison, executes a machine learning algorithm. The output of that machine learning algorithm includes predicted future changes to the topology, which the system uses to reduce the number of dimensions within the topology.

Abstract: Apparatuses, tables, and method of making the apparatuses and tables are disclosed for stowing and expanding a desk device. An exemplary apparatus, in one embodiment, includes a frame, a first surface slidably received by the frame in a horizontal plane between and including a stowed position and an expanded position, and a second surface slidably received by the frame between and including a stowed position and an expanded position.

Abstract: A buffer circuit is disclosed. The buffer circuit includes a command address (C/A) interface to receive an incoming activate (ACT) command and an incoming column address strobe (CAS) command. A first match circuit includes first storage to store failure row address information associated with the memory, and first compare logic. The first compare logic is responsive to the ACT command, to compare incoming row address information to the stored failure row address information. A second match circuit includes second storage to store failure column address information associated with the memory, and second compare logic. The second compare logic is responsive to the CAS command, to compare the incoming column address information to the stored failure column address information. Gating logic maintains a state of a matching row address identified by the first compare logic during the comparison carried out by the second compare logic.

Abstract: This disclosure provides a method and system for desulfurizing fuel produced from pyrolysis of waste tires including adsorbing one or more polar sulfur molecules from the tire pyrolysis oil with a regenerable adsorbent, distilling the tire pyrolysis oil to separate the tire pyrolysis oil into at least two fuel products and regenerating and reusing the regenerable adsorbent material. By combining adsorption with distillation, and advantageously recycling byproducts, the methods of this disclosure allow for conversion of waste tires into fuel in a manner that is commercially viable and sustainable.

Abstract: Apparatus, methods, and computer-readable medium are disclosed for controlling positioning of a desk. An exemplary apparatus includes a tabletop, expandable legs, motors, position sensors, a processor, and a memory configured to store instructions. The motors alter a length of one of the expandable legs. The position sensors identify current position of each of the plurality of expandable legs. The instructions cause the processor to receive a sensor signal, a communication signal, or a command signal, receive the identified current position of one or more of the expandable legs, determine a projected length value for the one or more expandable legs responsive to the received sensor signal, the communication signal, or the command signal, and command one or more of the plurality of motors based on the projected length value for the one or more expandable legs and the identified current position of the one or more expandable legs.

Abstract: A system for removing a panel insert from a panel includes a main housing. A loading cap is coupled to the main housing. A tension knob is coupled to the main housing. The tension knob is configured to couple to a puller rod. A tension spring is within the main housing. The loading cap is configured to set the tension spring at an initial tension. The tension knob is configured to set the tension spring at a subsequent tension. A heater is configured to apply heat to the panel insert.

Abstract: A utility pole mounted charging station includes an enclosure for housing the charging station. The enclosure has a way to be mounted to the utility pole, coming in two sections that are bolted together around the utility pole. The charging station receives power, preferably by power lines that pass through a hollow core of the utility pole. Within the enclosure is an electric vehicle charging circuit that receives power from the power lines and the electric vehicle charging circuit provides charging power to a vehicle by way of a charging cable and a charging connector. A front access panel of the enclosure is held to the enclosure by a plurality of security screws.

Abstract: A system and a method for securing a panel insert to a panel include a main housing, a heater within the main housing, a coupling rod extending from the main housing, and a clamp assembly coupled to the coupling rod. The clamp assembly is configured to clamp the panel insert to the panel. The heater is configured to cure an adhesive applied to the panel insert to bond the panel insert to the panel.

Abstract: Methods, systems, and tables are disclosed for charging multiple devices on a surface and providing feedback. An exemplary method includes sensing a location of a wirelessly rechargeable device on a charging surface of the wirelessly charging surface device and wirelessly powering the wirelessly rechargeable device via a portion of the charging surface corresponding to the sensed location of the wirelessly rechargeable device. The method also includes receiving charging status information from the wirelessly rechargeable device and outputting a human perceptible indication responsive to the received charging status information and the sensed location of the wirelessly rechargeable device.

Abstract: An information management system may store information related to tasks to be performed by workers in an organization. Workers in the organization may communicate with the information management system using email messages. The information management system may not require a login or authentication procedure, and workers may interact with the information management system without the need to log in to the information management system. The information management system may receive an email message from a worker that indicates a request for a report. The information management system may determine whether to transmit the report to the worker based on whether the worker is appropriately registered with the information management system, and/or whether the worker has administrative privileges. The information management system, in response to a positive determination, may transmit the report to the email address from which the requesting email message was sent.

Abstract: A method and system desulfurizes fuel produced from pyrolysis of waste tires and includes hydroprocessing tire pyrolysis oil to desulfurize the tire pyrolysis oil and obtain a hydroprocessed pyrolysis oil. The hydroprocessed oil is distilled into at least two environmentally fuel products selected from the group consisting of kerosene, naphtha, fuel oil, fuel and diesel. By combining hydroprocessing with distillation, and advantageously recycling byproducts, the methods of this disclosure allow for conversion of waste tires into fuel in a manner that is commercially viable and sustainable.

Abstract: A bidirectional electroosmotic pump may be provided. The bidirectional electroosmotic pump may be made of materials that are biocompatible and non-ferrous. The bidirectional electroosmotic pump may be part of an implantable medical device for the purpose of medicine delivery. The bidirectional electroosmotic pump may contain a working fluid and may facilitate the delivery of a separate payload fluid. In an exemplary embodiment, the bidirectional pump may contain bellows which may allow the pump to deliver the payload fluid through a series of valves and/or catheters. In another embodiment the bidirectional electroosmotic pump may contain a pump sensing mechanism to monitor the state of the pump.

Abstract: A cable assembly includes a cable having an insulator holding a first signal conductor and a second signal conductor and a cable shield surrounding the insulator. Exposed portions of the signal conductors extend forward of an end of the insulator for termination to a circuit card. The cable assembly includes a ground clip coupled to the end of the cable. The ground clip includes a bottom ground rake below the cable and a top ground hood above the cable. The bottom ground rake includes a window that receives the exposed portions of the first and second signal conductors therethrough. The bottom ground rake includes a lower grounding tab electrically connected to a lower portion of the cable shield and the top ground hood includes an upper grounding tab electrically connected to an upper portion of the cable shield. The bottom ground rake is coupled to the circuit card to support the cable relative to the circuit card.