Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.

Abstract: Methods of characterizing an analyte using a detector such as a nanopore and an enzyme are provided. One aspect features methods for characterizing a double-stranded polynucleotide using a detector, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.

Abstract: A system and method are provided for warning of an exposure of a second individual to an allergen by transfer from a first individual. Movements of the individuals are tracked so that allergen types and levels to which the individuals have been exposed can be obtained. Using knowledge of user sensitivity information to different allergens, it is determined if the first individual has been exposed to allergen types and levels which pose a risk to the second individual by GPS transfer from the first individual to the second individual. Thus, action can be taken when there is a determined risk of allergen transfer between individuals.

Abstract: The present disclosure relates to a writing instrument comprising a tubular body, a reservoir for an ink composition. The writing instrument comprises a nib comprising a switchable flow material, wherein the switchable flow material is configured to switch between a fluid flow preventing condition and a fluid flow enabling condition by a stimulus. The switchable flow material is configured to control flow of the ink composition from the reservoir to or towards a writing surface.

Abstract: A robotic platform associated with one or more software services enables remote users to interact with an environment and other humans physically and visually through a robotic surrogate over any distance utilizing the internet. The robotic surrogate is controlled through a non-technical user interface which responds to user control inputs made through natural user arm movements which are tracked in three dimensional space.

Abstract: Technologies disclosed herein are directed to context-based mobile device management. According to one embodiment, an application executing in a mobile device detects an event to trigger context-based management of the mobile device. A usage context associated with the mobile device is determined. One or more policies to enforce on the mobile device are identified as a function of the usage context. The application enforces the one or more policies on the mobile device.

Abstract: Technologies disclosed herein are directed to enforcing blocking functionality on a mobile device (e.g., a mobile device within a vehicle). The mobile device receives a request to disable a blocking of a user interaction with one or more functions of the mobile device. The mobile device prompts a capture of an image by a camera of the mobile device. The mobile device determines whether the image is captured from a passenger space in the vehicle. Once so determined, the mobile device disables the blocking of the user interaction with the one or more functions of the mobile device.

Abstract: A fire suppression system includes a feed port and a channel to couple the feed port to an actuation chamber. A solenoid valve controllably blocks a connection between the feed port and the channel. Pressure from the feed port builds up in the actuation chamber based on the solenoid valve unblocking the connection. A piston is in communication with the actuation chamber. The system also includes an inlet port closed off by a disc. The piston travels through the inlet port and burst the disc based on the pressure in the actuation chamber. An outlet port is coupled to the inlet port.

Abstract: A method of updating a payment card includes receiving a payment card having an existing payment part. The method includes removing the existing payment part from the payment card and installing a new payment part with the payment card for subsequent use of the payment card.

Abstract: Systems, methods, and devices for managing predetermined functions on a mobile device, the operating system (OS) installed on the device including an event application programming interface (API) configured to enable voice over internet protocol (VoIP) applications to assume priority over other applications and functions of the mobile device when VoIP calls are detected. A mobile device management software application installed and running on the mobile device emulates a VoIP software application and uses event API calls to trick the OS into believing that a VoIP call has been detected and, in response, causes the OS to block or interfere with one or more predetermined functions on the mobile device based on the status and location of the mobile device.

Abstract: Technologies disclosed herein are directed to context-based mobile device management. According to one embodiment, an application executing in a mobile device detects an event to trigger context-based management of the mobile device. A usage context associated with the mobile device is determined. One or more policies to enforce on the mobile device are identified as a function of the usage context. The application enforces the one or more policies on the mobile device.

Abstract: A computer-implemented method for designing a user-specific writing skill game is provided. The computer-implemented method comprises tracking a handwriting performance and generating a digital representation of the handwriting performance. The handwriting performance is performed by a user with a writing instrument. The method further comprises identifying user-specific handwriting skills which require improvement based on the digital representation of the handwriting performance. Then a writing skill game is designed. The writing skill game is designed to include one or more game tasks to be performed by the user. The one or more game tasks require the user to apply the user-specific handwriting skills which are to be improved.

Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.

Abstract: Described herein are concepts, system and techniques which provide a means to construct robust high-field superconducting magnets using simple fabrication techniques and modular components that scale well toward commercialization. The resulting magnet assembly—which utilizes non-insulated, high temperature superconducting tapes (HTS) and provides for optimized coolant pathways—is inherently strong structurally, which enables maximum utilization of the high magnetic fields available with HTS technology. In addition, the concepts described herein provide for control of quench-induced current distributions within the tape stack and surrounding superstructure to safely dissipate quench energy, while at the same time obtaining acceptable magnet charge time. The net result is a structurally and thermally robust, high-field magnet assembly that is passively protected against quench fault conditions.

Abstract: A razor cartridge includes a skin-contacting surface configured to contact a user's skin surface during a shaving operation. The skin-contacting surface includes a variable friction resistance element having a frictional resistance which is dependent on a motion direction of the razor cartridge over the user's skin surface.

Abstract: The management server obtains address information indicating a user's address and evaluation information indicating evaluation of a food or a restaurant performed by the user. A food search screen is provided with, as one of search filters, a search filter for filtering foods or restaurants on the basis of results of evaluation of foods or restaurants performed by residents of a certain area. If the user's address indicated by the address information is included in the certain area, the evaluation information indicating the evaluation of the food or the restaurant performed by the user is included in the results of the evaluation of the foods or the restaurants performed by the residents of the certain area.

Abstract: Technologies disclosed herein are directed to context-based mobile device management. According to one embodiment, an application executing in a mobile device detects an event to trigger context-based management of the mobile device. A usage context associated with the mobile device is determined. One or more policies to enforce on the mobile device are identified as a function of the usage context. The application enforces the one or more policies on the mobile device.

Abstract: Technologies disclosed herein are directed to enforcing blocking functionality on a mobile device (e.g., a mobile device within a vehicle). The mobile device receives a request to disable a blocking of a user interaction with one or more functions of the mobile device. The mobile device prompts a capture of an image by a camera of the mobile device. The mobile device determines whether the image is captured from a passenger space in the vehicle. Once so determined, the mobile device disables the blocking of the user interaction with the one or more functions of the mobile device.

Abstract: The present disclosure relates to constructs, such as antibody molecules comprising a binding domain specific to CD45, said binding domain comprising SEQ ID NO: 1, 2, 3 and/or SEQ ID NO: 4, 5 and 6. The disclosure also extends to pharmaceutical compositions comprising said constructs and use of the constructs/compositions in treatment.

Abstract: Technologies disclosed herein are directed to context-based mobile device management. According to one embodiment, an application executing in a mobile device detects an event to trigger context-based management of the mobile device. A usage context associated with the mobile device is determined. One or more policies to enforce on the mobile device are identified as a function of the usage context. The application enforces the one or more policies on the mobile device.