Patents by Inventor John A. Zebala

John A. Zebala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of antifolate neurotoxicity
    Publication number: 20040266808
    Abstract: The present invention is a method of treating antifolate neurotoxicity in a mammal suffering from or at risk of developing antifolate neurotoxicity, which comprises administering to the mammal a therapeutically effective amount of an NMDA antagonist, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 28, 2004
    Publication date: December 30, 2004
    Inventors: Barton A. Kamen, John A. Zebala
  • Thermostable ligase mediated DNA amplification system for the detection of genetic diseases
    Publication number: 20040048308
    Abstract: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase in assays for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
    Type: Application
    Filed: September 12, 2003
    Publication date: March 11, 2004
    Inventors: Francis Barany, John Zebala, Deborah Nickerson, Robert J. Kaiser, Leroy Hood
  • Solvent resistant photosensitive compositions
    Patent number: 6569598
    Abstract: Photoresist compositions and methods are provided for preparing photoresist films that are stable and impermeable to a broad range of organic solvents. Photoresist films provided herein may be photopatterned by selectively applying light, and may be stripped from a surface using unreactive agents. Photopatterned films may be used, for example, to selectively direct organic reagents to a solid support for the purpose of performing regionally selective solid-phase chemical synthesis with micron-scale resolution.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: May 27, 2003
    Assignee: Syntrix Biochip, Inc.
    Inventor: John A. Zebala
  • Solvent resistant photosensitive compositions
    Publication number: 20030064316
    Abstract: Photoresist compositions and methods are provided for preparing photoresist films that are stable and impermeable to a broad range of organic solvents. Photoresist films provided herein may be photopatterned by selectively applying light, and may be stripped from a surface using unreactive agents. Photopatterned films may be used, for example, to selectively direct organic reagents to a solid support for the purpose of performing regionally selective solid-phase chemical synthesis with micron-scale resolution.
    Type: Application
    Filed: April 17, 2001
    Publication date: April 3, 2003
    Inventor: John A. Zebala
  • Light-mediated method and apparatus for the regional analysis of biologic material
    Patent number: 6159681
    Abstract: Compositions and methods are provided for performing regional analysis of biologic materials. The methods provided herein employ a photoresist layer that is established over a biologic material (which may be immobilized on a substrate). Regions of interest are selected and irradiated to expose specific regions of biologic material. Exposed biologic material may then be selectively analyzed using any of a variety of analytic methods.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: December 12, 2000
    Assignee: Syntrix Biochip, Inc.
    Inventor: John A. Zebala
  • Thermostable ligase mediated DNA amplification system for the detection of genetic diseases
    Patent number: 6054564
    Abstract: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: April 25, 2000
    Assignees: Cornell Research Foundation, Inc., California Institute of Technology
    Inventors: Francis Barany, John Zebala, Deborah Nickerson, Robert J. Kaiser, Jr., Leroy Hood
  • Thermostable ligase mediated DNA amplification system for the detection of genetic diseases
    Patent number: 5830711
    Abstract: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 3, 1998
    Assignees: Cornell Research Foundation, Inc., California Institute of Technology
    Inventors: Francis Barany, John Zebala, Deborah Nickerson, Robert J. Kaiser, Jr., Leroy Hood
  • Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
    Patent number: 5494810
    Abstract: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase in a ligase chain reaction (LCR) assay for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: February 27, 1996
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Francis Barany, John Zebala, Deborah Nickerson, Robert J. Kaiser, Jr., Leroy Hood