Abstract: Optical sensing of biological targets is provided using a metasurface having guided mode resonances with electric field profiles that extend out from the metasurface. Surface functionalization of such metasurfaces can be used to provide sensing for biological targets, such as nucleic acids, proteins, small molecules, extracellular vesicles, and whole cells. Binding of the target to the surface functionalization can affect the resonance wavelength of the guided mode resonances, thereby providing a sensitive assay for the biological targets.

Abstract: This invention relates to a method and system as a branded club product (goods and services) discounting membership, universal discount card technology, hardware infrastructure, operational and software corporate team amalgamation, seller and buyer critical mass, essential implementation and real-time operational approach to integrate internet e-commerce with in-store commerce in physical store locations, at the point of sale (POS) checkout at store registers, of initially hundreds and eventually thousands of sellers, electronically and operationally, launching and igniting a whole new generation of advertising, buying and selling.