Abstract: Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Abstract: A system can register a first client and a second client to respectively receive information about updates to a write-ahead log structured storage engine that comprises a log. The system can read an entry in the log, the entry being of an update type. The system can, in response to determining that the first client is registered to receive at least some of the information about updates that are of the update type, sending, to the first client, entry information about the entry. The system can, in response to determining that the second client is registered to receive information about updates that are of the update type, sending, to the second client, the entry information about the entry.

Abstract: A system can register a first client and a second client to respectively receive information about updates to a write-ahead log structured storage engine that comprises a log. The system can read an entry in the log, the entry being of an update type. The system can, in response to determining that the first client is registered to receive at least some of the information about updates that are of the update type, sending, to the first client, entry information about the entry. The system can, in response to determining that the second client is registered to receive information about updates that are of the update type, sending, to the second client, the entry information about the entry.

Abstract: In assembly for dispensing agents into drains and the like, includes a retaining member having a perforate wall structure substantially surrounding and enclosing a quantity of a sanitizing agent therein. The retaining member is preferably flexible and tubular, and may be formed into a donut-shaped configuration. The retaining member may be provided of a mesh material. The mesh initially holds the sanitizing agent, provided as a powder or in granular form therein. Upon wetting of the sanitizing agent, it may assume a gel-like consistency and erode to dispense the sanitizing agent into the liquid passing through the retaining member. A mount may be employed to both hold the retaining member in a proper position and configuration, and to secure edges of the retaining member in a closed position.