Abstract: The invention presented is a remedial opioid overdose mixture that includes a therapeutically effective dose of an opioid receptor antagonist; and, a therapeutically effective dose of an opioid receptor agonist. In one embodiment, the opioid receptor antagonist is naloxone while the opioid receptor agonist is nalbuphine. One specific naloxone derivative is NX-90 and a specific nalbuphine derivative is NB-33. The mixture can be administered intranasally, intravenously and by autoinjector. In some dose mixtures, reversal time is about three minutes.

Abstract: The subject invention pertains to compositions comprising an opioid receptor antagonist and an opioid receptor agonist and methods of inhibiting an opioid overdose in a subject. The opioid receptor antagonist can be naloxone or a derivative thereof, while the opioid receptor agonist can be nalbuphine or a derivative thereof. The composition can be administered intranasally, intravenously and by autoinjector. The reversal time can be about three minutes.

Abstract: The invention presented is a remedial opioid overdose mixture that includes a therapeutically effective dose of an opioid receptor antagonist; and, a therapeutically effective dose of an opioid receptor agonist. In one embodiment, the opioid receptor antagonist is naloxone while the opioid receptor agonist is nalbuphine. One specific naxolone derivative is NX-90 and a specific nalbuphine derivative is NB-33. The mixture can be administered intranasally, intravenously and by autoinjector. In some dose mixtures, reversal time is about three minutes.

Abstract: A provider, such as a transportation management service, can manage transport for a number of riders between various locations. A system can determine that a customer is in a vehicle, prompt the customer regarding the customer's preferences, and modify a trip characteristic based on the response. The customer can be a rider in a vehicle shared by other passengers such as in a ride sharing environment. The customer can request transit with a transit service; such a request may include at least one time component, such as a requested time of departure or arrival. A system can prompt the customer about the customer's preferences when the system determines that the customer is otherwise unoccupied. The system can use the responses to build a profile for the customer based on the responses. The system can then modify a vehicle characteristic and/or a route based on the profile and responses.

Abstract: A provider, such as a transportation management service, can manage transport for a number of riders between various locations. Individual routes can include at least two segments using the same or different modes of transportation. A customer can select a transportation option for the journey that causes reservations to be made for the various segments. It might subsequently be determined that the customer will be unable to make a connection for at least one of the segments. Using information such as an estimated time of arrival of the current segment, the customer can be rebooked on an alternate transportation option that will enable the customer to be transported to the target destination according to the criteria for the journey. Segments can be rebooked for other reasons as well, such as where a better segment option becomes available or is discovered.