Abstract: An aircraft includes an airframe defining a first enclosed space, an engine bay disposed within the first enclosed space, and a cooling system. The engine bay includes a firebox defining a second enclosed space and an engine disposed at least partially within the second enclosed space. The cooling system is configured to selectively fluidly couple the first enclosed space with the second enclosed space.

Abstract: A grinder tool with blind mounting of a disc includes a center alignment mechanism having a first contact and a second contact and a rotational device including an axle that is movable with respect to the center alignment mechanism. A hub is mounted to the axle including a first coupling interface. The disc has a second coupling interface for mating with the first coupling interface. The center alignment mechanism is movable a mounting distance relative to the hub and contacts the disc with the first contact and the second contact to center align the first coupling interface with the second coupling interface. The rotational device is to slowly rotate the hub to angle align the first coupling interface with the second coupling interface to allow the disc to mate and attach to the hub.

Abstract: A tool for operating on a workpiece includes a motion actuator and a controller that responsively varies a speed of the motion actuator and an operating speed of a working surface. The controller is configured to respond to a derived force that is a function an applied force exerted by an operator to manageably adjust pressure on the working surface to achieve a rate of work. The controller changes simultaneously both a rate of work on the workpiece and the operating speed of the working surface according to a sensitivity profile. The simultaneous change of rate of work and operating speed is manageable under both acceleration and deceleration by the operator with the applied force. The sensitivity profile expresses a relationship of a monotonically increasing positive slope between the derived force and the operating speed of the working surface within the range.

Abstract: A grinder tool with blind mounting of a disc includes a center alignment mechanism having a first contact and a second contact and a rotational device including an axle that is movable with respect to the center alignment mechanism. A hub is mounted to the axle including a first coupling interface. The disc has a second coupling interface for mating with the first coupling interface. The center alignment mechanism is movable a mounting distance relative to the hub and contacts the disc with the first contact and the second contact to center align the first coupling interface with the second coupling interface. The rotational device is to slowly rotate the hub to angle align the first coupling interface with the second coupling interface to allow the disc to mate and attach to the hub.

Abstract: A tool for operating on a workpiece includes a motion actuator and a controller that responsively varies a speed of the motion actuator and an operating speed of a working surface. The controller is configured to respond to a derived force that is a function an applied force exerted by an operator to manageably adjust pressure on the working surface to achieve a rate of work. The controller changes simultaneously both a rate of work on the workpiece and the operating speed of the working surface according to a sensitivity profile. The simultaneous change of rate of work and operating speed is manageable under both acceleration and deceleration by the operator with the applied force. The sensitivity profile expresses a relationship of a monotonically increasing positive slope between the derived force and the operating speed of the working surface within the range.

Abstract: A controller coupled to a motion actuator responsively varies a speed of the motion actuator and an operating speed of a working surface within the range of an initial speed and a max speed and responds to a derived force that represents an amount of force an operator applies between a workpiece and the working surface. The controller, under both acceleration and deceleration, allows the operator with an applied force to manageably change simultaneously both a rate of work on the workpiece and the operating speed of the working surface according to a sensitivity profile expressing a relationship between the derived amount of force and the operating speed of the working surface. A tool for operating on the workpiece includes the motion actuator coupled to the working surface to engage the workpiece.

Abstract: A controller coupled to a motion actuator responsively varies a speed of the motion actuator and an operating speed of a working surface within the range of an initial speed and a max speed and responds to a derived force that represents an amount of force an operator applies between a workpiece and the working surface. The controller, under both acceleration and deceleration, allows the operator with an applied force to manageably change simultaneously both a rate of work on the workpiece and the operating speed of the working surface according to a sensitivity profile expressing a relationship between the derived amount of force and the operating speed of the working surface. A tool for operating on the workpiece includes the motion actuator coupled to the working surface to engage the workpiece.

Abstract: The present invention relates to dihydrobenzodiazepine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such dihydrobenzodiazepine derivatives are useful in the treatment of diseases associated with inappropriate ROCK kinase.

Abstract: The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.

Abstract: The present invention relates to dihydrobenzodiazepine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such dihydrobenzodiazepine derivatives are useful in the treatment of diseases associated with inappropriate ROCK kinase.

Abstract: The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.

Abstract: The present invention relates to pyridopyrazolopyrimidine derivatives that are useful pharmacological agents through the inhibition or antagonism of protein kinases, and to processes for the preparation and use of the same. In particular, the present invention relates to compounds that demonstrate protein tyrosine kinase and/or protein serine/threonine kinase inhibition.

Abstract: The present invention relates to aminopyrazine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medcicaments. Such aminopyrazine derivatives are useful in the treatment of diseases associated with inappropriate tyrosine and/or serine/threonine kinase activity.

Abstract: A quick set clamp device 10 includes a clamp frame 12, a slide shaft 14 having a longitudinal dimension that cooperates with the clamp frame 12 to removably secure the clamp frame device 10 to an object, a biasing member 16 adjacently disposed to the slide shaft 14, the biasing member 16 having a first end 18 that engages an outer first end portion 20 of the clamp frame 12, a binding member 22 having a first portion that slidably engages the slide shaft 14, a retaining member 26 retractably secured to the outer first end portion 20 of the clamp frame 12, the retaining member 26 engaging a second portion 28 of the binding member 22, a first engagement member 30 secured to a first end 32 of the slide shaft 14, and a second engagement member 34 secured to an inner second end portion 36 of the clamp frame 12.

Abstract: Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, R2, and R4 are various substituent groups, are protein kinase inhibitors

Abstract: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract: An adjustable support 12 for a stringed musical instrument such as a cello 10 includes a shaft 14 that is removably inserted into the cello 10, and a support member 16 that is adjustably disposed upon and secured to the shaft 14. The support member 16 includes an insertion portion 26 with a stabilizing bushing 72 disposed thereupon for stabilized insertion into an aperture in a bottom portion 11 of the cello 10, an annular portion 28 with an annular wall 34 for engaging and supporting the bottom portion 11 of the cello 10, and a lower portion 30 for securing the support member 16 circumferentially about a cylindrical outer wall 18 of the shaft thereby allowing an artist playing the cello to select a comfortable elevated and stabilized position of the cello 10 above a floor surface.

Abstract: Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, (R2, and R4 are various substituent groups, are protein kinase inhibitors.

Abstract: The apparatus comprises a manifold rotatably attached to the undersurface of a toilet seat extending from front to back and shaped so that when it is rotated against the undersurface it skirts the opening in the seat. A lever is provided at the front end of the manifold for use in moving it between its in use position with the plane of the manifold normal to the undersurface and its stowed position, essentially flat against the undersurface. The back end of the manifold is joined by a rotary joint to a supply tube, also mounted on the undersurface near the back of the seat and at a right angle to the manifold. A valve in this tube controls flow to the manifold. There are several orifices in the manifold, directing flow upward when the manifold is in use. There are movable sleeves on the manifold, one near each orifice, used to close off any orifice(s) when desired. In its stowed position the portion of the manifold in which the orifices are located lies in a channel attached to the undersurface.