Patents by Inventor John Allan Hamilton

John Allan Hamilton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OSTEOARTHRITIS TREATMENT
    Publication number: 20200247895
    Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA). In accordance with the present invention, an antagonist of GM-CSF can be effective in the treatment of osteoarthritis. An antagonist of GM-CSF includes, but is not limited to, an antibody that is specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
    Type: Application
    Filed: March 31, 2020
    Publication date: August 6, 2020
    Applicant: The University of Melbourne
    Inventors: John Allan Hamilton, Andrew David Cook
  • METHOD FOR THE TREATMENT OF PAIN AND OSTEOARTHRITIS WITH C-FMS ANTAGONISTS
    Publication number: 20180237531
    Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present invention, an antagonist of c-Fms is effective in the treatment of osteoarthritis and/or pain. An antagonist of M-CSF includes, but is not limited to, an antibody that is specific for M-CSF, IL-34 or c-Fms.
    Type: Application
    Filed: April 17, 2018
    Publication date: August 23, 2018
    Inventors: Stefan STEIDL, John Allan HAMILTON, Andrew David COOK
  • Method for treatment of osteoarthritis with C-Fms antagonists
    Patent number: 10005840
    Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present invention, an antagonist of c-Fms is effective in the treatment of osteoarthritis and/or pain. An antagonist of M-CSF includes, but is not limited to, an antibody that is specific for M-CSF, IL-34 or c-Fms.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: June 26, 2018
    Assignees: MORPHOSYS AG, THE UNIVERSITY OF MELBOURNE
    Inventors: Stefan Steidl, John Allan Hamilton, Andrew David Cook
  • OSTEOARTHRITIS TREATMENT
    Publication number: 20180066062
    Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA). In accordance with the present invention, an antagonist of GM-CSF can be effective in the treatment of osteoarthritis. An antagonist of GM-CSF includes, but is not limited to, an antibody that is specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
    Type: Application
    Filed: November 13, 2017
    Publication date: March 8, 2018
    Applicant: The University of Melbourne
    Inventors: John Allan Hamilton, Andrew David Cook
  • Pain treatment
    Patent number: 9834599
    Abstract: The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the treatment of pain. Antagonists of GM-CSF include, but are not limited to, antibodies which are specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: December 5, 2017
    Assignee: THE UNIVERSITY OF MELBOURNE
    Inventors: John Allan Hamilton, Andrew David Cook
  • PAIN TREATMENT
    Publication number: 20160311896
    Abstract: The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the treatment of pain. Antagonists of GM-CSF include, but are not limited to, antibodies which are specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
    Type: Application
    Filed: April 29, 2016
    Publication date: October 27, 2016
    Inventors: John Allan Hamilton, Andrew David Cook
  • Use of c-Fms antagonists
    Publication number: 20160185867
    Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present invention, an antagonist of c-Fms is effective in the treatment of osteoarthritis and/or pain. An antagonist of M-CSF includes, but is not limited to, an antibody that is specific for M-CSF, IL-34 or c-Fms.
    Type: Application
    Filed: December 16, 2015
    Publication date: June 30, 2016
    Inventors: Stefan Steidl, John Allan Hamilton, Andrew David Cook
  • OSTEOARTHRITIS TREATMENT
    Publication number: 20160185868
    Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA). In accordance with the present invention, an antagonist of GM-CSF can be effective in the treatment of osteoarthritis. An antagonist of GM-CSF includes, but is not limited to, an antibody that is specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
    Type: Application
    Filed: December 18, 2015
    Publication date: June 30, 2016
    Inventors: John Allan Hamilton, Andrew David Cook
  • Methods of treating pain using an antibody specific for GM-CSF
    Patent number: 9352034
    Abstract: The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the treatment of pain. Antagonists of GM-CSF include, but are not limited to, antibodies which are specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: May 31, 2016
    Assignee: The University of Melbourne
    Inventors: John Allan Hamilton, Andrew David Cook
  • Use of M-CSF antibodies in the treatment of osteoarthritis or pain
    Patent number: 9243066
    Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present invention, an antagonist of c-Fms is effective in the treatment of osteoarthritis and/or pain. An antagonist of M-CSF includes, but is not limited to, an antibody that is specific for M-CSF, IL-34 or c-Fms.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: January 26, 2016
    Assignees: University of Melbourne, Morpho Sys AG
    Inventors: Stefan Steidl, John Allan Hamilton, Andrew David Cook
  • Osteoarthritis treatment
    Patent number: 9243061
    Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA). In accordance with the present invention, an antagonist of GM-CSF can be effective in the treatment of osteoarthritis. An antagonist of GM-CSF includes, but is not limited to, an antibody that is specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: January 26, 2016
    Assignee: University of Melbourne
    Inventors: John Allan Hamilton, Andrew David Cook
  • METHOD OF TREATMENT AND AGENTS USEFUL FOR SAME
    Publication number: 20150368348
    Abstract: The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.
    Type: Application
    Filed: May 19, 2015
    Publication date: December 24, 2015
    Inventors: John Allan Hamilton, Gary Peter Anderson, Ian Keith Campbell
  • TREATMENT OF CHRONIC INFLAMMATORY CONDITIONS
    Publication number: 20150017180
    Abstract: A method for the treatment of a chronic inflammatory condition in a patient which comprises administration to the patient of an agent which blocks or inhibits IL-3 signalling events in the patient.
    Type: Application
    Filed: May 12, 2014
    Publication date: January 15, 2015
    Applicant: CSL Limited
    Inventors: Gino Luigi Vairo, John Allan Hamilton, Andrew David Cook
  • Use of c-Fms antagonists
    Publication number: 20140205608
    Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present invention, an antagonist of c-Fms is effective in the treatment of osteoarthritis and/or pain. An antagonist of M-CSF includes, but is not limited to, an antibody that is specific for M-CSF, IL-34 or c-Fms.
    Type: Application
    Filed: July 17, 2012
    Publication date: July 24, 2014
    Applicants: MorphoSys AG, The University of Melbourne
    Inventors: Stefan Steidl, John Allan Hamilton, Andrew David Cook
  • Pain treatment
    Publication number: 20130243791
    Abstract: The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the treatment of pain. Antagonists of GM-CSF include, but are not limited to, antibodies which are specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
    Type: Application
    Filed: May 28, 2013
    Publication date: September 19, 2013
    Applicant: The University of Melbourne
    Inventors: John Allan Hamilton, Andrew David Cook
  • Method of treating pain using an antagonist of GM-CSF
    Patent number: 8475796
    Abstract: The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the treatment of pain. Antagonists of GM-CSF include, but are not limited to, antibodies which are specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: July 2, 2013
    Assignee: University of Melbourne
    Inventors: John Allan Hamilton, Andrew David Cook
  • Osteoarthritis treatment
    Publication number: 20120003234
    Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA). In accordance with the present invention, an antagonist of GM-CSF can be effective in the treatment of osteoarthritis. An antagonist of GM-CSF includes, but is not limited to, an antibody that is specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
    Type: Application
    Filed: December 21, 2009
    Publication date: January 5, 2012
    Applicant: THE UNIVERSITY OF MELBOURNE
    Inventors: John Allan Hamilton, Andrew David Cook
  • Pain treatment
    Publication number: 20110287027
    Abstract: The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the treatment of pain. Antagonists of GM-CSF include, but are not limited to, antibodies which are specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
    Type: Application
    Filed: December 21, 2009
    Publication date: November 24, 2011
    Applicant: THE UNIVERSITY OF MELBOURNE
    Inventors: John Allan Hamilton, Andrew David Cook
  • TREATMENT OF CHRONIC INFLAMMATORY CONDITIONS
    Publication number: 20100209341
    Abstract: A method for the treatment of a chronic inflammatory condition in a patient which comprises administration to the patient of an agent which blocks or inhibits IL-3 signalling events in the patient.
    Type: Application
    Filed: February 17, 2010
    Publication date: August 19, 2010
    Inventors: Gino Luigi Vairo, John Allan Hamilton, Andrew David Cook
  • Anti-inflammatory compositions and methods
    Patent number: 5817305
    Abstract: Therapeutic compositions and methods for the treatment of inflammation are disclosed. The compositions comprise at least one anti-inflammatory drug in combination with the lymphokine interleukin-4 (IL-4), which components interact synergistically in the treatmement of inflammation. Methods for the treatment of inflammation comprise administering to a subject in need of such treatment an effective amount of at least one anti-inflammatory drug and IL-4.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: October 6, 1998
    Assignee: University Of Melbourne
    Inventors: John Allan Hamilton, Prudence Hamilton Hart