Abstract: A distributed acoustic sensing system can include an optical interferometer. The optical interferometer can include an optical fiber coupler to split optical light signals, and an optical fiber delay coil to introduce a controlled time delay in one of the paths. At least one path can form a loop, enabling controlled delay and temporary storage of light, resulting in interference patterns. The system can progressively mitigate noise or distortion, improving sensitivity and/or signal reception quality for defect detection.

Abstract: An eye-imaging apparatus including red, green, and blue light sources, one or more optical lenses, a light guide cable to transmit light from the light source, a one-chip color image sensor including a shutter, the color image sensor being operable to measure red, green, and blue light in the imaging path and transmit measured colored light in respective red, green, and blue channels. The red, green, and blue light sources are sequentially flashed in synchronization with the operation of the image sensor and the color image sensor captures red, green, and blue images in synchronization with the flashed color. The color image sensor transmits the colored images on respective color channels one at a time.

Abstract: The marking system includes one or more ink compositions and a color-change agent composition. The ink composition applied to a substrate such that it is a first color, but when a color-change agent is applied, one or more secondary colors appear. The ink compositions each have a respective ink color and include a respective: at least one first dye composition having a respective first color and at least one second dye composition having a respective second color. The first dye composition can react with the color-change agent composition. When the color-change agent composition contacts the ink composition, each respective first dye composition reacts with the color-change agent composition, 10 thereby producing each respective second color. Each respective first color is different from each respective second color, and each respective second color is different from each respective ink color.

Abstract: A cryogenic needle of a cryogenic system is coupled to a heater. While the needle is inserted into target tissue beneath skin, the heater provides heat to protect the skin. Power supplied to the heater is used to interpolate performance of the needle and/or operating parameters of the cryogenic system.

Abstract: A method in which a nerve associated with a spasticity in a limb of a patient may be identified. The cryogenic cooling needle may be inserted through a skin surface. The cryogenic cooling needle may be positioned to a target tissue such that the distal end of the cryogenic cooling needle is proximate to the nerve by bending the needle, wherein the needle has varying stiffness at a proximal portion and a distal portion. A treatment cycle may be delivered to a target tissue proximate to the nerve, the treatment cycle may comprise a cooling phase wherein cooling fluid flows into the lumen so that liquid from the cooling fluid flow vaporizes within the lumen to provide cooling to the nerve so as to treat spasticity.

Abstract: An eye-imaging apparatus including red, green, and blue light sources, one or more optical lenses, a light guide cable to transmit light from the light source, a one-chip color image sensor including a shutter, the color image sensor being operable to measure red, green, and blue light in the imaging path and transmit measured colored light in respective red, green, and blue channels. The red, green, and blue light sources are sequentially flashed in synchronization with the operation of the image sensor and the color image sensor captures red, green, and blue images in synchronization with the flashed color. The color image sensor transmits the colored images on respective color channels one at a time.

Abstract: An eye-imaging apparatus and system is described including circular fiber array ends arranged at skewed angles relative to the optical axis of the imaging path, a light intensity distribution converter along the illumination path to convert a bell-shaped distribution into a top-hat distribution, an image sensor, and high frequency response light source(s) operating in flash illumination mode in synchronization with the image sensor. As a result, unnecessary exposure of illumination light to a patient eye is minimized while the illumination light can span a wide enough coverage range with desired intensity and spectral distribution to cover the desired angular field of view and spectral range on a retina.

Abstract: A method in which a nerve associated with a spasticity in a limb of a patient may be identified. The cryogenic cooling needle may be inserted through a skin surface. The cryogenic cooling needle may be positioned to a target tissue such that the distal end of the cryogenic cooling needle is proximate to the nerve by bending the needle, wherein the needle has varying stiffness at a proximal portion and a distal portion. A treatment cycle may be delivered to a target tissue proximate to the nerve, the treatment cycle may comprise a cooling phase wherein cooling fluid flows into the lumen so that liquid from the cooling fluid flow vaporizes within the lumen to provide cooling to the nerve so as to treat spasticity.

Abstract: A cryogenic needle of a cryogenic system is coupled to a heater. While the needle is inserted into target tissue beneath skin, the heater provides heat to protect the skin. Power supplied to the heater is used to interpolate performance of the needle and/or operating parameters of the cryogenic system.

Abstract: A prism array light redistribution apparatus for an eye imaging system including light transmitting fibers, light receiving fibers, and a micro prism array optically coupled to bridge the light transmitting fibers and the light receiving fibers, configured to receive light having a bell-shaped angular distribution from the light transmitting fibers and refract light emitted by the light transmitting fibers to enter the light receiving fibers.

Abstract: The present invention relates to compounds of Formula I: wherein R1, L1, A, Xa, L2, B and Xb are each as defined herein. The present invention also relates to compounds of Formula II and III defined herein, formed by self-assembly of the compounds of Formula I with a metal M and an anion Q. Compounds of Formula II and III are useful in the treatment of proliferative disorders, such as cancer. The present invention also relates to pharmaceutical compositions comprising compounds of Formula I, II or III, and to the use of these compounds and compositions in the treatment of proliferative disorders, such as cancer.

Abstract: Embodiments include a cryogenic device for alleviating pain by cryogenically treating a nerve, the cryogenic device including a handpiece; a needle coupled to a distal end of the handpiece, the needle including a needle lumen, the needle being configured for insertion into a skin of a patient along an insertion axis at a site laterally displaced from a treatment zone proximate to the nerve. The needle is configured to resiliently bend after insertion away from the insertion axis, such that at least a portion of the needle is adapted to traverse a skin layer laterally toward the treatment zone. The device includes a cooling fluid supply tube extending distally into the needle lumen; and a cooling fluid source, wherein the cooling fluid source is coupled to the cooling fluid supply tube to direct cooling fluid into the needle lumen.

Abstract: A time-of-flight, TOF, mass spectrometer, MS, comprising: an ion source for supplying a group of ions, including a first ion having a first mass-to-charge ratio m1/z1, a second ion having a second mass-to-charge ratio m2/z2 and a third ion having a third mass-to-charge ratio m3/z3 wherein m3/z3>m2/z2>at a time t0; a first set of electrodes, including a first electrode, and a second set of electrodes, including a first electrode and an Nth electrode, wherein the first set of electrodes and the second set of electrodes are mutually spaced apart by a gap therebetween; an ion detector for detecting the ions; a set of power supplies, including a first power supply, electrically coupled to the first set of electrodes and to the second set of electrodes; and a controller configured to control the set of power supplies to apply respective potentials to the first set of electrodes and the second set of electrodes; wherein the controller is configured to control the set of power supplies to: provide a first subst

Abstract: Users of electronic audio and video playback devices have become familiar with listening and viewing media from stored memory. Music may be listened to and any art may be viewed including television, motion pictures, still images and any other copyrightable works of audible or visual art, the types of which are vast. Traditional indexing criteria for such stored memory may include artist or author identification, track or work of art title, genre, era or origin, style of art, and other criteria pertaining to the work itself. According to the present invention, media elements stored in memory may now be characterized by entering criteria based on the qualitative attributes and emotive features ascertained upon playback or subsequent evaluation which are then associated with each stored audio, video, image or other file, for subsequent indexing, searching and recommendation operations.

Abstract: Embodiments include a cryogenic device for alleviating pain by cryogenically treating a nerve, the cryogenic device including a handpiece; a needle coupled to a distal end of the handpiece, the needle including a needle lumen, the needle being configured for insertion into a skin of a patient along an insertion axis at a site laterally displaced from a treatment zone proximate to the nerve. The needle is configured to resiliently bend after insertion away from the insertion axis, such that at least a portion of the needle is adapted to traverse a skin layer laterally toward the treatment zone. The device includes a cooling fluid supply tube extending distally into the needle lumen; and a cooling fluid source, wherein the cooling fluid source is coupled to the cooling fluid supply tube to direct cooling fluid into the needle lumen.

Abstract: A motor control system configured to detect a pinch condition of a structure actuated by a motor includes a pinch detection module configured to receive a current signal indicative of a motor current, determine a rate of change of current based on the current signal, and generate a pinch signal indicative of the pinch condition in response to either one of the motor current being greater than a current threshold and the rate of change of current being greater than a rate of change threshold. The motor control system further includes a position control module configured to control the motor to actuate the structure in response to an input and at least one of stop and reverse the motor in response to the pinch signal.

Abstract: A prism array light redistribution apparatus for an eye imaging system including light transmitting fibers, light receiving fibers, and a micro prism array optically coupled to bridge the light transmitting fibers and the light receiving fibers, configured to receive light having a bell-shaped angular distribution from the light transmitting fibers and refract light emitted by the light transmitting fibers to enter the light receiving fibers

Abstract: A method and apparatus for treatment planning using four dimensional imaging data.

Abstract: A prism array light redistribution apparatus for an eye imaging system including light transmitting fibers, light receiving fibers, and a micro prism array optically coupled to bridge the light transmitting fibers and the light receiving fibers. The array may be further configured to receive light having a bell-shaped angular distribution from the light transmitting fibers and refract the received light to enter the light receiving fibers such that a square-shaped angular distribution of light emits from a light emitting end of the light receiving fibers.

Abstract: An eye-imaging apparatus and system is described including arrayed optical fibers having a high numerical aperture and circular fiber array ends arranged at skewed angles relative to the optical axis of the imaging path. Circular fiber array ends are arranged to emit the illumination light into an eye at a skewed angle and a light intensity distribution converter along the illumination path to convert a bell-shaped distribution into a top-hat distribution. As a result, illumination uniformity on the retina of the eye is improved.