Abstract: A composition includes a clathrate compound that has guest molecules and carrier molecules that trap the guest molecules. The carrier molecules are a saccharide and the guest molecules include at least one of a cannabinoid or a terpene. The clathrate compound includes, by combined weight of the carrier molecules and the guest molecules, at least 18% of the guest molecules.

Abstract: A composition includes n-acyl ethanolamine, at least one cannabinoid, and at least one terpene. The composition may be in the form of a tablet.

Abstract: A detection method or a method for a point of care diagnostic assay which comprises detecting non-covalently bound copper (free copper) concentrations in a fluid.

Abstract: Compositions and methods are provided that comprise improved means to achieve and maintain a targeted level of copper status in persons in order to treat and prevent copper associated diseases.

Abstract: A method and apparatus for making non-staining coffee or tea includes an ion exchanger for removing heavy metals from the brewed coffee or tea or from the water used to brew the coffee or tea.

Abstract: The present invention relates to an electrochemical method for detecting a target polynucleotide. An electrode comprising an electrode surface is provided. The electrode surface includes at least one probe molecule reverisbly immobilized with respect to the electrode surface. A first electrochemical signal indicative of an amount of probe molecule immobilized with respect to the electrode surface is obtained. The electrode surface is contacted with a liquid comprising the target polynucleotide. Upon the contacting step, at least some of the probe molecule immobilized with respect to the electrode surface dissociates therefrom. A second electrochemical signal indicative of an amount of probe molecule immobilized with respect to the electrode surface is obtained. The presence of the target polynucleotide is determined at least partially on the basis of the first and second electrochemical signals.

Abstract: An oligonucleotide probe for DNA detection is disclosed. The oligonucleotide probe includes a site-specific sequence. Either a co-factor or a mediator is conjugated to the site-specific sequence. The co-factor is adapted to produce an enzymatic signal that is electrochemically detectable. The mediator is adapted to enhance an enzymatic signal that is electrochemically detectable.

Abstract: Methods and systems for processing polynucleotides (e.g., DNA) are disclosed. A processing region includes one or more surfaces (e.g., particle surfaces) modified with ligands that retain polynucleotides under a first set of conditions (e.g., temperature and pH) and release the polynucleotides under a second set of conditions (e.g., higher temperature and/or more basic pH). The processing region can be used to, for example, concentrate polynucleotides of a sample and/or separate inhibitors of amplification reactions from the polynucleotides. Microfluidic devices with a processing region are disclosed.