Patents by Inventor John Ambrose
John Ambrose has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12630585Abstract: There is currently a high demand for new therapeutic antibiotics with new mechanisms of action. Disclosed are two small molecules, tryglysin A and B, with novel chemical structures and potent antibiotic activity against a narrow spectrum of bacteria. This narrow spectrum of activity indicates the tryglysins could be working through a novel antibiotic mechanism of action. Due to this narrow spectrum, the tryglysins could be used as highly targeted therapeutics to treat or prevent disease without disturbing other important, “beneficial” bacteria within the human microbiome, which is a great improvement over virtually all other clinically used antibiotics that are broad-spectrum. The tryglysins are potent against several streptococcal pathogens, including Streptococcus pneumonia, the leading cause of pneumonia, and Streptococcus mutans, the primary causative agent of tooth decay and gum disease.Type: GrantFiled: December 8, 2021Date of Patent: May 19, 2026Assignees: THE TRUSTEES OF PRINCETON UNIVERSITY, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Mohammad R. Seyedsayamdost, Michael J. Federle, Brett C. Covington, Leah B. Bushin, Britta E. Rued, John Ambrose
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Publication number: 20240051995Abstract: There is currently a high demand for new therapeutic antibiotics with new mechanisms of action. Disclosed are two small molecules, tryglysin A and B, with novel chemical structures and potent antibiotic activity against a narrow spectrum of bacteria. This narrow spectrum of activity indicates the tryglysins could be working through a novel antibiotic mechanism of action. Due to this narrow spectrum, the tryglysins could be used as highly targeted therapeutics to treat or prevent disease without disturbing other important, “beneficial” bacteria within the human microbiome, which is a great improvement over virtually all other clinically used antibiotics that are broad-spectrum. The tryglysins are potent against several streptococcal pathogens, including Streptococcus pneumonia, the leading cause of pneumonia, and Streptococcus mutans, the primary causative agent of tooth decay and gum disease.Type: ApplicationFiled: December 8, 2021Publication date: February 15, 2024Applicant: The Trustees of Princeton UniversityInventors: Mohammad R. SEYEDSAYAMDOST, Michael J. FEDERLE, Brett C. COVINGTON, Leah B. BUSHIN, Britta E. RUED, John AMBROSE
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Patent number: 11628347Abstract: A golf putter grip includes a main body with a generally rounded diamond cross sectional shape and having and integrated green reading and alignment system, wherein the integrated green reading and alignment system includes two break measurement lines, each break measurement line on one side of the grip and configured to assist the golfer in gauging the angle of the flag, and wherein the integrated green reading and alignment system includes at least two alignment lines on a top of the grip and associated with the two break measurement lines and configured to assist in adjusting a club head face of an associated putter based upon the gauged angle of the flag. A golf putter implementing the golf putter grip with a conventional shaft and head with club face is disclosed.Type: GrantFiled: December 1, 2021Date of Patent: April 18, 2023Assignee: LATERAL LINE, LLCInventor: John Ambrose
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Publication number: 20220168622Abstract: A golf putter grip includes a main body with a generally rounded diamond cross sectional shape and having and integrated green reading and alignment system, wherein the integrated green reading and alignment system includes two break measurement lines, each break measurement line on one side of the grip and configured to assist the golfer in gauging the angle of the flag, and wherein the integrated green reading and alignment system includes at least two alignment lines on a top of the grip and associated with the two break measurement lines and configured to assist in adjusting a club head face of an associated putter based upon the gauged angle of the flag. A golf putter implementing the golf putter grip with a conventional shaft and head with club face is disclosed.Type: ApplicationFiled: December 1, 2021Publication date: June 2, 2022Inventor: John Ambrose
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Patent number: 10682557Abstract: A golf putter grip comprises a main body extending at least 7 inches, more preferably about 14 inches, from a top to a bottom end, a flat front surface has a width less than 1.75 inches, generally about 1.60 to 1.65 inches, and a shaft receiving bore within the grip extending substantially to the top end, wherein the bore is centered between lateral sides of the grip and the bore is angled relative to the main body's longitudinal centerline extending away from the front surface in the direction toward the bottom end. A putter incorporating this grip yields a better tempo and motion, will neutralize the dominant hand and forearm throughout the stroke, will stabilizes the hands and allow for a quieter grip to aid in reducing the yips, and will reduce the wrist angle at address to relieve arm tension.Type: GrantFiled: September 28, 2016Date of Patent: June 16, 2020Inventor: John Ambrose
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Publication number: 20170087430Abstract: A golf putter grip comprises a main body extending at least 7 inches, more preferably about 14 inches, from a top to a bottom end, a flat front surface has a width less than 1.75 inches, generally about 1.60 to 1.65 inches, and a shaft receiving bore within the grip extending substantially to the top end, wherein the bore is centered between lateral sides of the grip and the bore is angled relative to the main body's longitudinal centerline extending away from the front surface in the direction toward the bottom end. A putter incorporating this grip yields a better tempo and motion, will neutralize the dominant hand and forearm throughout the stroke, will stabilizes the hands and allow for a quieter grip to aid in reducing the yips, and will reduce the wrist angle at address to relieve arm tension.Type: ApplicationFiled: September 28, 2016Publication date: March 30, 2017Inventor: John Ambrose
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Publication number: 20070042012Abstract: A Game Attracting Substance and a Method for Applying such substance comprised of a container, a solution of game attractant scent in a non-liquid sprayable foam or gel and a release mechanism whereby the contents of the container, the non-liquid foam or get containing the game attracting scent solution can be applied to a substrate. The same attracting substance is formulated such that a non-liquid three-dimensional mound of such substance can be applied to the top or underside of a horizontal substrate or a vertical substrate and thus be protected from environmental elements and yet exposed to air currents such as to effect disbursal of the scent. The device and the method of application solve problems existing with the present state of the art in that the scent containing medium as applied to the substrate is completely free of contamination by the hunter in that the hunter never comes into contact with the scent containing medium.Type: ApplicationFiled: August 18, 2005Publication date: February 22, 2007Inventors: John Ambrose, John Ambrose
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Publication number: 20050223494Abstract: A medical table handling device includes a handle, configured to be grasped by a user to manipulate the medical table, a pair of opposite clamps, coupled on opposing ends of the handle, each clamp having a slot being configured to receive one of a pair of lateral rails of the medical table therein, and means for securing each of the pair of clamps to one of the lateral rails.Type: ApplicationFiled: February 18, 2005Publication date: October 13, 2005Inventors: John Ambrose, Russell Stuart
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Publication number: 20050085736Abstract: An apparatus for detecting a myocardial infarction including a housing and a plurality of electrodes extending from the housing. Each of the plurality of electrodes is placed at a predetermined position on a body of a user for obtaining data representing bodily activity. A processor is positioned within the housing and connected to the plurality of electrodes. The processor analyzes the data obtained by the plurality of electrodes to form a baseline ECG and records the formed ECG. A means for storing the data representing the baseline ECG value is connected to the processor. The apparatus further includes a means for notifying a user of a myocardial infarction. Upon positioning the plurality of electrodes on the body of the user subsequently to storing the formed ECG, the plurality of electrodes obtain data representing current bodily activity. The processor then compares the current data to the stored.Type: ApplicationFiled: October 17, 2003Publication date: April 21, 2005Inventors: John Ambrose, John Coppola, Mary DeVoe
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Patent number: 6746511Abstract: A continuous method of manufacturing a liquid dispersion containing submicron metal or metal compound particles inside a liquid bath. A metal-containing fluid with carrier gas mixture is bubbled through the liquid bath and predetermined conditions in the bath cause the fluid to decompose to form the submicron sized metal or metal compound particles in the liquid.Type: GrantFiled: July 3, 2002Date of Patent: June 8, 2004Assignee: Inco LimitedInventors: Eric B. Wasmund, Richard S. Adams, John Ambrose, Armen Markarian, Dirk Naumann, Lloyd Timberg, Rinaldo Stefan
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Publication number: 20040003680Abstract: A continuous method of manufacturing a liquid dispersion containing submicron metal or metal compound particles inside a liquid bath. A metal-containing fluid with carrier gas mixture is bubbled through the liquid bath and predetermined conditions in the bath cause the fluid to decompose to form the submicron sized metal or metal compound particles in the liquid.Type: ApplicationFiled: July 3, 2002Publication date: January 8, 2004Applicant: Inco Limited, a Canadian corporationInventors: Eric B. Wasmund, Richard S. Adams, John Ambrose, Armen Markarian, Dirk Naumann, Lloyd Timberg, Rinaldo Stefan
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Patent number: 5839049Abstract: A process for varying the density of porous plated metal foams. Especially useful for battery plate applications, a plated foam is coated with a slurry of predetermined size metal power, particularly nickel, and then sintered. The resultant density of the metal foam may be adjusted as needed.Type: GrantFiled: April 24, 1996Date of Patent: November 17, 1998Assignee: Inco LimitedInventors: Victor A. Ettel, John Ambrose, Paul A. Hynek, Peter J. Kalal, Lloyd M. Timberg, David K. Vallbacka
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Patent number: 5700363Abstract: A porous nickel electrode substrate having a central high conductivity core sandwiched between two layers of porous conductive material such as nickel foam or nickel felt. The porous conductive material is plated with nickel and then sintered. By selectively controlling the plating of nickel on the porous material, variable conductivities may be designed into the substrate.Type: GrantFiled: February 15, 1996Date of Patent: December 23, 1997Assignee: Inco LimitedInventors: Victor Alexander Ettel, John Ambrose, Kirt Kenneth Cushnie, James Alexander E. Bell, Vladimir Paserin, Peter Joseph Kalal
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Patent number: 5497086Abstract: A sensor for measuring the density of a magnetic porous material such as foam. The sensor includes a load cell connected to a magnet. The magnet is spaced a predetermined distance away from the material. The load sensed by the pull of the magnet is translated into a perceivable density value.Type: GrantFiled: April 15, 1994Date of Patent: March 5, 1996Assignee: Inco LimitedInventors: Paul A. Hynek, Vladimir Paserin, John Ambrose
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Patent number: 5124011Abstract: The invention provides a method of monitoring reagent levels in aqueous copper electrolytic solutions. To determine the amount of glue present in an electrowinning solution, potential is applied, decreasing in a cathodic direction (more negative) to initiate a first cycle peak. The first cycle peak is compared to a known to determine amount of glue in the solution. Additionally, voltage is cycled between upper and lower voltages to monitor glue/lignosulfonate ratios. Hysteresis and cycle stability are measured at reference voltages and compared to known hysteresis and cycle stability values to monitor glue/lignosulfonate ratio of electrolytic solutions.Type: GrantFiled: October 24, 1989Date of Patent: June 23, 1992Assignee: Inco LimitedInventors: Brian D. Rogers, Carl C. Smith, Raymond L. Brisebois, John Ambrose
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Patent number: 5077699Abstract: Ocean bottom mapping is carried out by projecting a sonic pulse in the form f a fan-shaped beam from a vessel toward the ocean floor, receiving echoes by an array of sonic detectors extending athwartship, repeatedly taking instantaneous, simultaneous, snapshot-like samples of all of the detectors in the array, and, by means of a digital computer, applying a beam-forming transform, such as a Fast Fourier Transform, to the samples, thereby producing a spectrum of amplitudes versus angles. The directions of the floor areas from which the snapshot data emanate are determined from refinement of the peaks in the spectrum of amplitudes, and the distances of the same floor areas from the vessel are determined by the time interval between the pulse and the sample. A bottom profile is constructed from the directions and distances so determined. Two alternative techniques for refining and interpreting spectrum data are described.Type: GrantFiled: December 7, 1990Date of Patent: December 31, 1991Assignee: The United States of America as represented by the Secretary of the NavyInventors: Anthony P. Passamante, Paul A. Labonski, Nancy J. Harned, Timothy B. Hediger, John Ambrose
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Patent number: 4534935Abstract: Sponge titanium powder is compacted, advantageously by roll compaction to a density in the range of about 60% to 80% of the density of solid titanium metal, thereafter heat treated in vacuum at about 500.degree. C. to 750.degree. C., cooled in vacuum to 300.degree. C. and quenched to 100.degree. C. to provide a substrate for electrodes useful in electrolytic processes.Type: GrantFiled: January 9, 1984Date of Patent: August 13, 1985Assignee: INCO LimitedInventors: John Ambrose, Douglas K. Charles, Bruce R. Conard, Carlos Diaz, Charles E. O'Neill, Wayne P. Leavoy
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Patent number: 4274930Abstract: A cobaltic oxide hydrate is mixed with spent sulfate electrolyte and the slurry is sparged with air to liberate any entrained chloride ions as gaseous chlorine. Thereafter a reducing agent is used to enable dissolution of the cobalt and obtaining of a chloride-free solution from which, after purification, cobalt can be electrowon.Type: GrantFiled: July 28, 1980Date of Patent: June 23, 1981Assignee: The International Nickel Company, Inc.Inventors: Victor A. Ettel, Eric A. P. Devuyst, Juraj Babjak, John Ambrose, Gerald V. Glaum
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Patent number: 4153079Abstract: A flexible hose line which may be used for loading and unloading oil tankers having a secondary fluid retaining reinforcement carcass to retain leakage and to indicate by radial expansion failure of the main carcass. The secondary carcass may be of high elongation material or may have an angle of lay of the reinforcement to give radial expansion on pressurization.Type: GrantFiled: April 15, 1975Date of Patent: May 8, 1979Assignee: Dunlop LimitedInventor: John Ambrose
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Patent number: 4087338Abstract: An electrolyte containing an organic buffering agent is used to electrowin nickel with a comparatively high bite in a diaphragm-free cell.Type: GrantFiled: February 22, 1977Date of Patent: May 2, 1978Assignee: The International Nickel Company, Inc.Inventors: Aubrey Stewart Gendron, John Ambrose, Victor Alexander Ettel