Abstract: The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants.

Abstract: An electronic messaging device includes a receiver configured to receive a message at one of a first operational frequency and second operational frequency. The messaging device can operate using a time synchronous protocol and can receive commands through over-the-internet-programming (OTIP) and over-the-air-programming (OTAP).

Abstract: An apparatus and method for an inspection apparatus for inspecting a component. The inspection apparatus including a robotic arm. A micro-XRF instrument having an instrument head coupled to the robotic arm. A seat supporting the component within a scanning area during inspection; and a computer in communication with the robotic arm and the micro-XRF instrument.

Abstract: A computer-implemented American soccer training and evaluation method that includes subjecting a drilling user to predefined drilling protocol(s) of a plurality of American soccer drilling assemblies and obtain, from each pre-defined drilling protocol(s) of the plurality of American soccer drilling assemblies and from at least one sensor on each of the assemblies, at least one user physical characteristic of the drilling user. The user physical characteristic is communicated to an administrative server over a network, where it is stored and used to create a drilling user performance profile having individualized performance comparisons with respect to the at least one user physical characteristic of the drilling user and a performance benchmark. Then, the drilling user performance profile is communicated to at least one of a plurality of electronic computing devices of a plurality of consuming users for evaluation and review.

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, L1, L2, L3, X, a, b, c, n, and m are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity and uses as therapeutics as well as methods for treatment of subjects in need thereof, including prostate cancer are also provided.

Abstract: Provided are compounds of Formula I and pharmaceutically acceptable salt, solvate and/or derivative thereof. Further, provided are methods of treating a disease, disorder or condition mediated or treatable by activation of SHIP1 comprising administering a compound of Formula I or a pharmaceutically acceptable salt, solvate or derivative thereof. The compound of Formula I or a pharmaceutically acceptable salt, solvate or derivative thereof may be used in the treatment of SHIP1 mediated disease, disorder or conditions including inflammatory bowel disease (IBD), Crohn' disease, ulcerative colitis, multiple myeloma, liver injury, acute hepatitis and severe sepsis.

Abstract: A grill cleaning tool is disclosed that picks up remnant wire bristles that may be produced during the cleaning of a grill with wire bristle brush. The grill cleaning tool includes a handle having a proximal end and a distal end and a head connected to the distal end of the handle. The head has a top surface and a bottom surface and is wider than the handle. A magnet is also connected to the bottom surface of the head. A shroud is further provided that is removeably connected to the bottom surface of the head adjacent the magnet. The shroud substantially covers the magnet and is formed from a magnetically permeable material. In use, the handle is gripped by a user and moved across the grill with the bottom surface directed down toward the grill. The magnet is operable to magnetically attract the remnant metal bristles produced during a cleaning of the grill with the wire bristle cleaning tool and secure them against the shroud for later disposal.

Abstract: A computer-implemented American soccer training and evaluation method that includes subjecting a drilling user to predefined drilling protocol(s) of a plurality of American soccer drilling assemblies and obtain, from each pre-defined drilling protocol(s) of the plurality of American soccer drilling assemblies and from at least one sensor on each of the assemblies, at least one user physical characteristic of the drilling user. The user physical characteristic is communicated to an administrative server over a network, where it is stored and used to create a drilling user performance profile having individualized performance comparisons with respect to the at least one user physical characteristic of the drilling user and a performance benchmark. Then, the drilling user performance profile is communicated to at least one of a plurality of electronic computing devices of a plurality of consuming users for evaluation and review.

Abstract: The present invention relates to bifunctional Proteolysis Targeting Chimeric ligands (Protac compounds) comprising a ligase modulator/binder and a molecule that binds to a protein target of interest, and methods of treating various diseases and conditions with the Protac compounds, including diseases associated with androgen receptors.

Abstract: A computer-implemented American soccer training and evaluation method that includes subjecting a drilling user to pre-defined drilling protocol(s) of a plurality of American soccer drilling assemblies and obtain, from each pre-defined drilling protocol(s) of the plurality of American soccer drilling assemblies and from at least one sensor on each of the assemblies, at least one user physical characteristic of the drilling user. The user physical characteristic is communicated to an administrative server over a network, where it is stored and used to create a drilling user performance profile having individualized performance comparisons with respect to the at least one user physical characteristic of the drilling user and a performance benchmark. Then, the drilling user performance profile is communicated to at least one of a plurality of electronic computing devices of a plurality of consuming users for evaluation and review.

Abstract: The present invention relates to compounds of formula (I)-(VI) and/or (A)-(H-I), or any subgenera thereof, or a pharmaceutically acceptable salt, tautomer or stereoisomer. The compounds of the present disclosure are useful in modulating androgen receptor activity and for treating cancer including prostate cancer.

Abstract: Compounds having a structure of formula (I), (I-A), (Ia)-(Ie), (A)-(E), and (II) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of disorders including prostate cancer are also provided.

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

Abstract: Systems and methods for evaluating product research are disclosed herein. A user inputs product information to a website or app, after which a database is searched for documentation related to the product. This documentation is scanned for the answers to questions related to the product. Based on these answers, a unique score is generated that is indicative of the quality of the product research. The score provides consumers and companies a novel critical and dynamic analysis of the quality of research used to market a product, allowing consumers to become empowered to ask questions about a product from their healthcare provider or product supplier.

Abstract: The present disclosure generally relates to pharmaceutical compositions and combinations comprising an androgen receptor N-terminal domain inhibitor or an inhibitor and a second therapeutically active agent, such as an CDK4/6 inhibitor, a Pin1 inhibitor (inhibitor of peptidyl-prolyl cis/trans isomerases), or an antiandrogen. In particular, the present disclosure relates to pharmaceutical compositions and combinations useful for treatment of various cancers, for example breast cancer and prostate cancer. Further, the present disclosure relates administering an androgen receptor N-terminal domain inhibitor in combination with radiation therapy for treatment of various cancers.

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

Abstract: A computer-implemented American soccer training and evaluation method that includes subjecting a drilling user to pre-defined drilling protocol(s) of a plurality of American soccer drilling assemblies and obtain, from each pre-defined drilling protocol(s) of the plurality of American soccer drilling assemblies and from at least one sensor on each of the assemblies, at least one user physical characteristic of the drilling user. The user physical characteristic is communicated to an administrative server over a network, where it is stored and used to create a drilling user performance profile having individualized performance comparisons with respect to the at least one user physical characteristic of the drilling user and a performance benchmark. Then, the drilling user performance profile is communicated to to at least one of a plurality of electronic computing devices of a plurality of consuming users for evaluation and review.

Abstract: The present invention relates to compounds of formula (I)-(VI) and/or (A)-(H-I), or any subgenera thereof, or a pharmaceutically acceptable salt, tautomer or stereoisomer. The compounds of the present disclosure are useful in modulating androgen receptor activity and for treating cancer including prostate cancer.

Abstract: Compounds having a structure of formula (I), (I-A), (Ia)-(Ie), (A)-(E), and (II) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of disorders including prostate cancer are also provided.

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, L1, L2, L3, X, a, b, c, n, and m are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity and uses as therapeutics as well as methods for treatment of subjects in need thereof, including prostate cancer are also provided.