Abstract: The present invention provides novel drug-inducible degradation tags (degrons), as well as fusion proteins, cells and pharmaceutical compositions comprising the same. Nucleic acid sequences and vectors encoding the novel degrons are also provided. Methods of using the novel degrons, fusion proteins, cells, pharmaceutical compositions, nucleic acid sequences and vectors are also provided herein.

Abstract: A method of controlling a refrigerator includes instructing at least one camera to capture images forward of a main body opening of a main body of the refrigerator of items being placed into or removed from at least one storage compartment. The images are analyzed to determine whether the images contain an object of interest. The method further includes assigning a direction of movement for the object of interest being at least one of into or out of the storage compartment. An inventory for the storage compartment is updated based on the object of interest and the direction of movement for the object of interest. Instructions are then provided to at least one environmental control device. The instructions control the environmental control device to change a storage condition within the storage compartment based on the inventory in the storage compartment.

Abstract: A refrigerator includes a main body, a door, at least one camera mounted to the main body and/or the door and at least one computing device. The camera(s) is/are positioned to have a field of view that includes an entrance opening leading to a storage compartment and an interior side of the door when the door is open. The camera(s) is/are configured to capture images of an item being loaded into or being removed from the storage compartment. The computing device(s) can instruct the camera(s) to capture the images, analyze the captured images and determine whether the images contain an object of interest. The computing device(s) can assign a sensed door angle and an object location to images containing the object of interest. The computing device(s) can assign a direction of movement for the object of interest based on the sensed door angle and changes in the object location.

Abstract: A refrigerator system includes a main body and a door mounted to and movable with respect to the main body, an ambient light sensor, a light source, at least one camera positioned to have a field of view that includes an entrance opening leading to the at least one storage compartment, and at least one computing device in operable connection with the at least one camera, the ambient light sensor, and the light source.

Abstract: The present invention relates to novel antigen binding molecules which specifically bind to B7H3. The invention also relates to chimeric antigen receptors (CARs) and antibody-drug conjugates (ADCs) comprising the antigen binding molecules. Also provided are uses of the antigen binding molecules, CARs and ADCs, and pharmaceutical compositions comprising the antigen binding molecules, CARs and ADCs.

Abstract: A highlight microdot mask element includes: at least one imaged region having at least one imaged block and being optically transmissive; at least one opaque island formed by at least one non-imaged block, wherein an arrangement of the plurality of imaged regions and the at least one opaque island defines the highlight microdot print surface pattern; and an opaque void region surrounds the highlight microdot pattern. A flexographic plate highlight microdot printhead includes: at least one elevated region, each elevated region having at least one elevated block forming a print surface; at least one internal recess formed by at least one recessed block, wherein an arrangement of the plurality of elevated regions and the at least one recess define a the highlight microdot print surface pattern of a highlight microdot structure; and an recess void region surrounding the highlight microdot structure.

Abstract: A communications connection system includes an adapter module defining at least first and second ports and at least one media reading interface mounted at one of the ports. The first adapter module is configured to receive a fiber optic connector at each port. Some type of connectors may be formed as duplex connector arrangements. Some types of adapters may include ports without media reading interfaces. Some types of media reading interfaces include contact members having three contact sections.

Abstract: A refrigerator includes a main body, a door, at least one camera mounted to the main body and/or the door and at least one computing device. The camera(s) is/are positioned to have a field of view that includes an entrance opening leading to a storage compartment and an interior side of the door when the door is open. The camera(s) is/are configured to capture images of an item being loaded into or being removed from the storage compartment. The computing device(s) can instruct the camera(s) to capture the images, analyze the captured images and determine whether the images contain an object of interest. The computing device(s) can assign a sensed door angle and an object location to images containing the object of interest. The computing device(s) can assign a direction of movement for the object of interest based on the sensed door angle and changes in the object location.

Abstract: A refrigerator system includes a main body, at least one camera and at least one computing device in operable connection with the camera(s). The camera(s) is/are positioned to have a field of view that includes an entrance opening leading to a storage compartment(s) and is/are configured to capture images of an item being loaded into or being removed from the storage compartment(s). The computing device(s) is/are configured to instruct the camera(s) to capture the images, to analyze the captured images and generate a bounding box around an object of interest in the captured images that contain the object of interest, and to assign a direction of movement for the object of interest being at least one of into, out of or internally within the refrigerated enclosure. The direction of movement is assigned based on changes in size of the bounding box around the object of interest among the analyzed images.

Abstract: A transcript including a plurality of portions is processed. A reduced schema set from a structured document is generated by identifying a subset of schema rows from the structured document using the transcript. A reduced example set is generated by identifying a subset of examples from the structured document using the transcript. The reduced schema set and the reduced example set are composed into a reduced composite schema set. An instance of information is extracted from the transcript by processing a prompt including the reduced composite schema set with a generative artificial intelligence (AI) model using retrieval augmented generation (RAG). A schema row of the structured document is populated with the instance of information from the transcript.

Abstract: A method, computer program product, and computing system for flowsheet population by voice. Dictation or conversation is transcribed from voice to text. The keys and values relevant to the documentation are extracted from the transcript and used to populate the flowsheet by selecting a subset of rows and examples relevant to the transcription of the information from a plurality of rows in the flowsheet and based on the transcript, each row corresponding to a key and a value for the flowsheet and extracting an instance of information from the transcript of information associated with a key from the subset of rows by processing a prompt including at least a portion of the transcript of information and the subset of rows with a generative artificial intelligence (AI) model using retrieval augmented generation (RAG).

Abstract: A method, computer program product, and computing system for flowsheet population. A structured document conforming to a schema and having a plurality of rows, each row comprising a key and a value, is processed. A target key/value pair is identified within the structured document for a target instance of information. An in-context example of spoken text representative of the target instance of information corresponding to the target key/value pair is generated using a generative artificial intelligence (AI) model.

Abstract: Embodiments provide systems, methods, and computer storage media for management, assessment, navigation, and/or discovery of data based on data quality, consumption, and/or utility metrics. Data may be assessed using attribute-level and/or record-level metrics that quantify data: “quality”—the condition of data (e.g., presence of incorrect or incomplete values), its “consumption”—the tracked usage of data in downstream applications (e.g., utilization of attributes in dashboard widgets or customer segmentation rules), and/or its “utility”?a quantifiable impact resulting from the consumption of data (e.g., revenue or number of visits resulting from marketing campaigns that use particular datasets, storage costs of data). This data assessment may be performed at different stages of a data intake, preparation, and/or modeling lifecycle.

Abstract: A refrigerator includes a plurality of storage compartments within a refrigerated enclosure, a plurality of cameras mounted a main body or a door, and at least one computing device. The at least one computing device is configured to assign a direction to determine if an item is moving into, out of or internally within the refrigerated enclosure.

Abstract: Embodiments provide systems, methods, and computer storage media for management, assessment, navigation, and/or discovery of data based on data quality, consumption, and/or utility metrics. Data may be assessed using attribute-level and/or record-level metrics that quantify data: “quality”—the condition of data (e.g., presence of incorrect or incomplete values), its “consumption”—the tracked usage of data in downstream applications (e.g., utilization of attributes in dashboard widgets or customer segmentation rules), and/or its “utility”—a quantifiable impact resulting from the consumption of data (e.g., revenue or number of visits resulting from marketing campaigns that use particular datasets, storage costs of data). This data assessment may be performed at different stages of a data intake, preparation, and/or modeling lifecycle.

Abstract: The present invention provides a T cell which expresses a gamma-delta T cell receptor (TCR) and a chimeric antigen receptor (CAR), wherein the CAR comprises: an antigen binding domain; a transmembrane domain; and a co-stimulatory intracellular signalling domain; wherein the intracellular signalling domain provides a co-stimulatory signal to the T cell following binding of antigen to the antigen binding domain.

Abstract: A refrigerator includes a plurality of storage compartments within a refrigerated enclosure, a plurality of cameras mounted a main body or a door, and at least one computing device. The at least one computing device is configured to assign a direction to determine if an item is moving into, out of or internally within the refrigerated enclosure.

Abstract: A tire inflation assembly includes an air chuck that has a pair of outlets that has a direction of air flow which is oriented at a unique direction with respect to each other. In this way the air chuck can be attached to the valve stem at a variety of orientations to enhance employing the air chuck to inflate the tire. The air chuck includes a locking mechanism which engages the valve stem for retaining the air chuck on the valve stem. The locking mechanism is urgeable to disengage the valve stem to remove the air chuck from the valve stem. A pressure gauge is integrated into the air chuck to display the air pressure in the tire when either of the outlets is attached to the valve stem.

Abstract: Provision of a chimeric antigen receptor (CAR) comprising a disialoganglioside (GD2)-binding domain which comprises?a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences:?b) a light chain variable region (VL) having CDRs with the following sequences: T cells expressing such a CAR are useful in the treatment of some cancers.