Abstract: A surgical footswitch for controlling a surgical instrument. The surgical footswitch includes a base. A treadle is rotatably coupled to the base to operate the surgical instrument. A foot guard is also rotatably coupled to the base. A blocking portion of the foot guard is configured to prevent physical access to the treadle in a lateral direction in a first position and permit access to the treadle in a lateral direction in a second position. A floor engagement portion of the foot guard engages a floor surface when the blocking portion is in the first position. The floor engagement portion is spaced from the floor surface when the blocking portion is in the second position. The floor engagement portion permits physical access to the treadle in a longitudinal direction when the blocking portion is in both the first position and the second position.

Abstract: An interchangeable electro-mechanical lock core for use with a lock device having a locked state and an unlocked state is disclosed. The interchangeable electro-mechanical lock core may include a moveable plug having a first position relative to a lock core body which corresponds to the lock device being in the locked state and a second position relative to a lock core body which corresponds to the lock device being in the unlocked state. The interchangeable electro-mechanical lock core may include a core keeper moveably coupled to a lock core body. The core keeper may be positionable in a retain position wherein the core keeper extends beyond an envelope of lock core body to hold the lock core body in an opening of the lock device and a remove position wherein the core keeper is retracted relative to retain position to permit removal.

Abstract: Pinnacle concepts are not amenable to detection by the use of keywords. A unit of natural language discourse (UNLD) “refers” to a pinnacle concept “C” when that UNLD uses linguistic expressions in such a way that “C” is regarded as expressed, used or invoked by an ordinary reader of “L.” A reference can have a “reference level” value that is proportional to: the “strength” with which the pinnacle concept is referenced, the probability that a pinnacle concept is referenced or both strength and probability. Pinnacle concepts can be divided into Quantifiers and non-Quantifiers. A Quantifier can modify the reference level assigned to a non-Quantifier. A concept “C,” that is determined to be referenced by a UNLD “x,” after application of its Quantifiers, is said to be asserted by “x.” Concept-based classification is the identification of whether a pinnacle concept “C” is asserted by a UNLD. Concept-based classification can be used for concept-based search.

Abstract: Provided herein are compositions and methods for detecting the binding of a peptide to an MHC molecule, and the binding of a peptide:MHC complex to a TCR. In preferred embodiments, the compositions and methods are in a highly-multiplexed way. The compositions and methods disclosed herein can be used to provide direct information on which peptides are bound to an MHC molecule. Also provided is a method for simultaneously detecting a large number of peptides for binding to an MHC molecule and/or a T cell. A method for detecting competitive binding of a large number of peptides to an MHC molecule and/or a T cell is also disclosed. Also provided herein is a method for simultaneously detecting a large number of specific TCRs. The compositions and methods of the present invention are useful for vaccine design, research and monitoring of autoimmune and infectious disease, immunogenicity testing of therapeutics, and tissue typing.

Abstract: A catheter sheath device may include an elongate member and a moveable member. The elongate member may include a first lumen, and the moveable member may include a second lumen. The moveable member may be physically coupled to a portion of the elongate member to permit relative movement therebetween. A first relative movement between the moveable member and a portion of the elongate member may cause the second lumen to be positioned at a first location that permits delivery of at least a portion of a catheter into the second lumen but not into the first lumen from the second lumen. A second relative movement between the moveable member and the portion of the elongate member may cause the second lumen to be positioned at a second location that permits delivery of the at least the portion of the catheter through both the second lumen and the first lumen.

Abstract: A method of making an OLED device includes providing a first undercut lift-off structure over the device substrate having a first array of bottom electrodes. Next, one or more first organic EL medium layers including at least a first light-emitting layer are deposited over the first undercut lift-off structure and over the first array of bottom electrodes. The first undercut lift-off structure and overlying first organic EL medium layer(s) are removed by treatment with a first lift-off agent comprising a fluorinated solvent to form a first intermediate structure. The process is repeated using a second undercut lift-off structure to deposit one or more second organic EL medium layers over a second array of bottom electrodes. After removal of the second undercut lift-off structure, a common top electrode is provided in electrical contact with the first and second organic EL medium layers.

Abstract: A cross-flow heat exchanger for gas turbine engines which may be utilized to transfer heat from one fluid flow 46 to a second independent fluid flow wherein one of the fluid flows has a high differential inlet pressure and temperature. The heat exchanger has robust construction to inhibit mixing of the fluid flows during a single burst duct event.

Abstract: A control system an unmanned vehicle includes a first processing unit configured to execute a primary autopilot process for controlling the unmanned vehicle. The control system further includes a programmable logic array in operative communication with the first processing unit. The control system also includes a state machine configured in the programmable logic array. The state machine is configured to enable control of the unmanned vehicle according to a backup autopilot process in response to an invalid output of the first processing unit.

Abstract: Examples described herein relate to a network interface device comprising a multi-stage programmable packet processing pipeline circuitry to determine a path to transmit a packet based on relative network traffic transmitted via multiple paths. In some examples, determine a path to transmit a packet is based on Deficit Round Robin (DRR). In some examples, the programmable packet processing pipeline circuitry includes: a first stage to manage two or more paths, wherein a path of the two or more paths of the first stage is associated with two or more child nodes, a second stage to manage two or more paths, wherein a path of the two or more paths of the second stage is associated with two or more child nodes, and at least one child node is associated with the determined path.

Abstract: The disclosures herein relate to novel compounds of formula (1) and salts thereof, wherein V; W; X; Y; Z; R1; R2; R3; R4 and R5 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disorders associated with orexin receptors.

Abstract: Systems and methods of multi-participant interactive experiences are disclosed. Participants located location can interact with one another and share gaming, educational and other experiences. The system includes a coordination node to coordinate experiences between participants and one or more of interactive nodes. At each interactive node there is a main display that shows shared information to each of the participants and to other viewers. Each of the participants also uses a personal controller such as a smart phone which has a personal display. Information that is specific to the participant can be displayed on the personal controller.

Abstract: Stillage solids concentration methods are disclosed wherein a solids concentration aid is added to a process stream mixture in a corn to ethanol process. The solids concentration aid may comprise a cationic polymer coagulant or flocculant or both, a starch based coagulant or flocculant or a biologically derived (i.e., plant or animal origin) coagulant or flocculant. Acrylamide/quaternary ammonium copolymers and homopolymeric polydiallyldimethyl ammonium chloride polymers are noteworthy examples of suitable solids concentration aids.

Abstract: A computer-implemented system and method are provided for modifying and utilizing a sharable customer profile of a customer stored in a processing platform memory. The method comprises, during a scheduling phase, repeatedly performing a series of operations until an accepted itinerary is indicated. The series of operations include: receiving a set of initial or modified itinerary events, creating or modifying an itinerary utilizing the set of itinerary events, the customer profile, and vendor information that includes vendor employee scheduling information, and sending the itinerary to the customer for acceptance or modification of the itinerary or itinerary events. Once the itinerary is complete with no more modifications, the itinerary is finalized. Reservations are made at respective event vendors of the itinerary events, and confirmations for the event reservations are sent to the customer.

Abstract: A computer-implemented method for pacing a spend may include: (1) receiving, at a pacing computer program executed by a computer processor, a spend budget for a user for a period, wherein the spend budget represents income transactions for the period minus recurring or expected expense transactions for the period; (2) determining, by the pacing computer program, a pace of spend for the spend budget at a point in time for the period, wherein the pace of spend may be asymmetrical across the period; (3) determining, by the pacing computer program, a current spend for the period at the point of time; and (4) causing, by the pacing computer program, a display of an electronic device to graphically present the pace of spend for the point in time and the current spend for the period at the point in time.

Abstract: Cyclone Rolling Circle Amplification (CRCA) based next-generation sequencing (NGS) using a multiple primer rolling circle amplification (RCA) reaction is generated using two or more tandem primers from the same strand on different locations of library adaptor regions of double stranded enriched targeted polymerase chain reaction (PCR) library products. This process allows multiple initiation and syntheses of the RCA reaction by an enzyme on the same circular template molecule, which is beneficial since the two or more primers complement each other in generating uniform amplification of the target circle population. Also, a method for keeping DNA nanoballs (also known as rolonies) compact, or more compact, and for pre-priming rolonies before sequencing to eliminate the hybridization of a seqeuncing primer after seeding the rolonies, and a Rolonies rolling circle amplification (RCA) based next-generation sequencing (NGS) using a dual Rolonies primer approach named REPLI-Rolony.

Abstract: Disclosed is a wearable article continuous in a longitudinal direction and a transverse direction comprising a front elastic belt region, a back elastic belt region, a crotch region, a waist opening, and a pair of leg openings, wherein the article has a Belt Elastic Bonding Percentage of less than about 25% and an Individual Elastic Bonding Percentage of from about 10% to about 75%.

Abstract: Provided herein are polynucleotides comprising sequence configured to bind to a CRISPR effector protein. Modulation of one or more modifications of the polynucleotides can be used to tune the activity of CRISPR effector proteins complexed with the polynucleotides.

Abstract: Provided herein are polynucleotides and CRISPR effector proteins configured to be covalently bound together in a CRISPR complex. The polynucleotides can be further modified to modulate the activity of the CRISPR complex. Modification of the polynucleotide and CRISPR effector protein can be used to improve the efficacy of target binding and/or cleavage.

Abstract: In an embodiment, a polyurethane comprises the residues of i. an aliphatic diisocyanate, ii. an aliphatic diol comprising a poly(ethylene oxide) moiety, iii. an aliphatic diol comprising a polycarbonate moiety, and iv. a chain extender, wherein the polyurethane has a melting temperature of 140° C. or less and has a weight average molecular weight of from 100,000 to 500,000 g/mol. In an embodiment, the polyurethane is substantially devoid of catalyst. In an embodiment, the polyurethane is formed by reactive extrusion. In an embodiment, a medical device comprises the polyurethane and a bioactive agent. The medical devices, methods, and polyurethanes may exhibit benefits in end-product biostability, drug release profile, health and safety, and processing speed or reproducibility.

Abstract: Examples described herein relate to a switch comprising: circuitry, when operational, to receive a packet comprising a header and a payload and in conjunction with performance of computation on the packet payload, forward the packet header, but not the payload, to a destination endpoint. In some examples, the destination endpoint of the packet is to perform management of reliable transport. In some examples, the circuitry includes programmable data plane circuitry comprising ingress pipeline or egress pipeline and one or more match action units (MAUs) to perform processing of the payload, wherein the programmable data plane circuitry is to perform computation on the packet payload.