Abstract: This invention relates to methods and compositions for treatment of inv (16) leukemia and particularly to treatment of acute myeloid leukemia. Disclosed is a method of treating inv (16) leukemia comprising the step of administering to a subject in in need thereof a therapeutically effective combination of a) a compound of the formula (1) (1) and b) a BRD4 inhibitor selected from the group consisting of JQ1, CeMMECZ, 1-BET 151 (or GSK1210151A), 1-BET 762 (or GSK525762), PFI-1, bromosporine, OTX-015 (or MK-8628), TEN-010, CPI-203, CPI-0610, RVX-208, BI2536, TG101348, LY294002, ABBV-075 (or mivebresib), FT-1101, ZEN003694, pharmaceutically acceptable salts and mixtures thereof. The therapeutically effective combination synergistically inhibits proliferation of inv (16) leukemia cells. This invention also relates to pharmaceutical compositions comprising a therapeutically effective combination of the compound of formula (1) and the BRD4 inhibitor and a pharmaceutically acceptable excipient.

Abstract: The present invention includes Uttroside B compositions and method for the treatment of hepatocellular carcinoma. Chemotherapeutic options for liver cancer are limited and the prognosis of HCC patients remains dismal. Sorafenib, is the only drug currently available for the treatment of hepatocellular carcinoma.

Abstract: The present invention includes Uttroside B compositions and method for the treatment of hepatocellular carcinoma. Chemotherapeutic options for liver cancer are limited and the prognosis of HCC patients remains dismal. Sorafenib, is the only drug currently available for the treatment of hepatocellular carcinoma.

Abstract: This invention relates to methods and compositions for treatment of inv (16) leukemia and particularly to treatment of acute myeloid leukemia. Disclosed is a method of treating inv (16) leukemia comprising the step of administering to a subject in in need thereof a therapeutically effective combination of a) a compound of the formula (1) (1) and b) a BRD4 inhibitor selected from the group consisting of JQ1, CeMMECZ, 1-BET 151 (or GSK1210151A), 1-BET 762 (or GSK525762), PFI-1, bromosporine, OTX-015 (or MK-8628), TEN-010, CPI-203, CPI-0610, RVX-208, BI2536, TG101348, LY294002, ABBV-075 (or mivebresib), FT-1101, ZEN003694, pharmaceutically acceptable salts and mixtures thereof. The therapeutically effective combination synergistitally inhibits proliferation of inv (16) leukemia cells. This invention also relates to pharmaceutical compositions comprising a therapeutically effective combination of the compound of formula (1) and the BRD4 inhibitor and a pharmaceutically acceptable excipient.

Abstract: The present invention includes Uttroside B compositions and method for the treatment of hepatocellular carcinoma. Chemotherapeutic options for liver cancer are limited and the prognosis of HCC patients remains dismal. Sorafenib, is the only drug currently available for the treatment of hepatocellular carcinoma.

Abstract: The present invention includes Uttroside B compositions and method for the treatment of hepatocellular carcinoma. Chemotherapeutic options for liver cancer are limited and the prognosis of HCC patients remains dismal. Sorafenib, is the only drug currently available for the treatment of hepatocellular carcinoma.

Abstract: The vent assembly (10) includes a vent frame (14), a vent (16) and a retainer (40). The ven frame attaches to a sidewall (20) of the vehicle. The vent frame defines an opening and includes a projection. The vent is received within the opening and is removably attached to the vent frame. The retainer selectively secures the vent to the vent frame. The retainer is slidably mounted on the vent and is translatable between an engaged position and a non-engaged position. In the engaged position, the vent is secured to the vent frame through engagement of the retainer with the projection of the vent frame. In the non-engaged position, the vent may be removed from the vent frame.

Abstract: A refrigerator shelving system includes an item retainer for securing items carried on a shelf, a mounting member for releasably securing a shelf to a cabinet of the refrigerator, and a spill tray carried by the shelf. The item retainer is movable between a first position and a second position such that when in the first position, a first side upwardly extends from the shelf and defines a fence and when in the second position the first side is parallel and adjacent to an upper surface of the shelf The shelf mounting member includes a first portion rotatably interconnected to a lateral side of the shelf and a second portion for selectively engaging a horizontal slot of a cabinet of the refrigerator. The mounting member is rotatable from a first position to a second position to engage the second portion with the horizontal slot. The spill tray includes a main body portion and a plurality of mounting elements.

Abstract: A refrigerator storage bin includes a main body portion and a cover. The main body portion defines a bin storage area. The cover selectively provides access to the bin storage area. The cover is pivotally attached to a sidewal of a cabinet of the refrigerator for rotation about a pivot axis between an opened position and a closed position. The cover and main body portion include cooperating surfaces that articulate to cover from the closed position to the open position in response to translation of the main body portion from a first position to a second position.