Abstract: Anatomical and functional assessment of coronary artery disease (CAD) using machine learning and computational modeling techniques deploying methodologies for non-invasive Fractional Flow Reserve (FFR) quantification based on angiographically derived anatomy and hemodynamics data, relying on machine learning algorithms for image segmentation and flow assessment, and relying on accurate physics-based computational fluid dynamics (CFD) simulation for computation of the FFR.

Abstract: The technology disclosed provides systems and methods that display database objects representing entities, placement channels and workflow status in an insurance or other risk transfer program. Specially coded distribution trees and graphs of nodes represent the overall flow and, optionally, status of placement workflows. Node and edge data generated for display depicts multiple risk placements on behalf of at least one requesting party through intermediaries to responding parties. Line width of edges represents calculated relative size of placements, and pattern, style, and color of edges can depict statuses of the risk placements. Another geo-coded map display also depicts as nodes a requesting party, intermediaries and responding parties, connected by edges that represent communication channels.

Abstract: The present invention relates to a support frame for use with an edge protection system for elevated structures, such as building rooves. The support frame includes a first frame portion and a second frame portion mounted together so as to be axially slidable relative one another between an extended position for locating a post of the edge protection system alongside a roof edge of a building and a retracted position. The support frame further includes a coupling mount extending from an uppermost frame member for coupling to a portion of the building adjacent the roof edge and for receiving and supporting the post in an upright position alongside the roof edge of the building.

Abstract: Systems, methods, and computer-readable storage devices are disclosed for simulated choral audio chatter in communication systems. One method including: receiving audio data from each of a plurality of users participating in a first group of a plurality of groups for an event using a communication system; generating first simulated choral audio chatter based on the audio data received from each of the plurality of users in the first group; and providing the generated first simulated choral audio data to at least one user of a plurality of users of the event.

Abstract: Techniques are described herein for using a high-pressure reactor to separate clean water from dirty water without filtration and to extract and concentrate contaminants from dirty water for use as a fuel. In particular, techniques and systems are described for separating water from hydrocarbon contaminates, other BTU-laden compounds, and dissolved minerals, while also boiling water and condensing the resulting steam into distilled water. In addition, system in which the described techniques are performed can be used as a high-pressure pump for moving the separated hydrocarbon contaminates forward into other processes, such as a high-pressure reactor or incinerator.

Abstract: A map-based graphical user interface for a social media application displays to special social media activity information based on submission of geo-tagged social media items to the platform. For users and or submitted items that need predefined location fuzzing criteria, such activity is represented in the graphical user interface at an intentionally inaccurate position.

Abstract: A suspension kit is provided for use in heavy duty vehicles having an independent front suspension including air springs, the kit includes an anti-roll bar having two ends, each end configured for connection to the front suspension in operational relationship to an associated one of two front wheel assemblies, at least one ping tank in fluid communication with an associated one of the air springs, a valve in fluid communication between each at least one ping tank and the associated air spring, a control switch connected to each valve for moving the valve between an open position, allowing fluid communication between the at least one ping tank and the air spring, and a closed position, closing fluid communication between the at least one ping tank and the air spring. An associated front suspension is also provided.

Abstract: Processes and devices provide parenteral delivery of therapeutic fluids, in particular high-viscosity therapeutic fluids (e.g., protein therapeutics), by a chemical reaction that generates a gas. A device may include a first actuation chamber containing a first reagent, a second reaction chamber containing a second reagent, and a third therapeutic fluid chamber containing the therapeutic fluid. In a loaded configuration, a plunger separates the first chamber from the second chamber. In a delivery configuration, the plunger allows the first reagent from the first chamber to communicate and react with the second reagent from the second chamber. The generated gas acts upon a plunger to deliver the therapeutic fluid from the third chamber.

Abstract: Provided are therapeutic compositions containing microbial populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.

Abstract: The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Abstract: A composite wheel for use at normal tire pressures as well as at reduced tire pressures may include a spoke section with a mating surface, a barrel section in contact with the spoke section at said mating surface, and a bead hump with tire lock geometry on at least the spoke section. The barrel section may further include a bead hump with the tire lock geometry.

Abstract: An anthropomorphic test device utilizes a mounting mechanism for coupling a hollow member including a simulated flesh to a support structure, with the simulated flesh including a foam core portion covered with a skin portion. The mounting mechanism includes inserts, such as plastic or metal inserts having a flange portion and an elongated tubular member, which are introduced in multiple places within the simulated flesh with the flange portion within the foam core portion and the elongated tubular member extending through the skin portion. A fastening member is inserted through an elongated opening in the insert and within a receiving cavity portion of the support structure to secure the hollow member to the support structure. The hollow member may be a hollow pelvic member, and the support structure may be a pelvic support structure, with the hollow pelvic member secured to the pelvic support structure via the mounting mechanism.

Abstract: Anatomical and functional assessment of coronary artery disease (CAD) using machine learning and computational modeling techniques deploying methodologies for non-invasive Fractional Flow Reserve (FFR) quantification based on angiographically derived anatomy and hemodynamics data, relying on machine learning algorithms for image segmentation and flow assessment, and relying on accurate physics-based computational fluid dynamics (CFD) simulation for computation of the FFR.

Abstract: An intravascular therapy guidance system includes a processor circuit in communication with an extravascular imaging device. The processor circuit receives, from the extravascular imaging device, an extravascular image stream. The processor circuit determines a therapy region of a blood vessel in the extravascular image stream and outputs a screen display to a display in communication with processor circuit. The screen display includes the extravascular image stream of the blood vessel including movement of an intravascular therapy device within the blood vessel to deliver an intravascular therapy to the therapy region and a graphical representation of the therapy region overlaid on the extravascular image stream.

Abstract: The Ring of Life tourniquet system is a motorized tourniquet system with intelligent pads. This invention uses a metal band and pads to apply radial pressure to stop bleeding from an affected. The invention uses built-in injection ports that enable an individual to administer antibiotic prophylaxis to traumatized tissue and other medications. This system is developed to prevent infection to an affected area for an extended period, track and record heart rate, uses GPS tracking for rapid response and emergency communications. The device and medication can be applied with one hand alone or with no professional medical treatment.

Abstract: An anthropomorphic test device includes a spine assembly, a pair of clavicle assemblies coupled to the spine assembly, a pair of arms with a respective one arm coupled to a respective one clavicle assembly, and at least one pad assembly having a clavicle portion mounted to a respective one of the clavicle assemblies and positioned onto a respective one arm. Each pad assembly includes a clavicle portion, which includes an arm portion and a clavicle base region, and a neck portion, which includes a raised neck region and a neck base region. The neck portion and clavicle portion are each formed from materials with the neck portion being stiffer than the clavicle portion. The pad assembly is configured to provide a human-like response while reducing or eliminating entrapment of a shoulder belt during a crash test.

Abstract: A seal assembly is for sealing a space adjacent to a bearing and defined between an inner member and an outer member disposed about the inner member. The seal assembly includes an annular seal disposed about the inner member and having a sealing lip sealingly engageable with the inner member. An annular load ring is disposed within the outer member bore and has an inner circumferential surface defining a bore, the seal being disposed within the bore and coupled with the ring. A first axial end of the ring is disposed against the bearing outer ring, or a spacer disposed axially between the load ring and the bearing outer ring, and a second axial end is disposed against a radial surface of the outer member. The load ring is configured to support axial loading on, and to prevent axial displacement of, the bearing outer ring.

Abstract: The present invention relates to new extended release pharmaceutical compositions and methods of use thereof for the treatment of disorders.

Abstract: A seal assembly is for sealing a bearing disposed between an inner shaft and an outer hub and includes an annular inner case having an axial section disposable about the shaft shoulder and a radial section extending radially outwardly from the axial section. An annular outer case is disposed about the inner case, has an axial section coupleable with the hub and a radial section extending radially inwardly from the outer case axial section and spaced axially from the inner case radial section. An elastomeric seal member is attached to the outer case radial section and has a sealing lip sealingly engaged with the axial section of the inner case. An annular positioner is coupled with the inner case and has a radial section engageable with the axial end of the bearing inner ring so as to locate the inner case at a desired position along the central axis.

Abstract: A seal assembly is for sealing a space adjacent to a bearing and defined between an inner member and an outer member disposed about the inner member. The seal assembly includes an annular seal disposed about the inner member and having a sealing lip sealingly engageable with the inner member. An annular load ring is disposed within the outer member bore and has an inner circumferential surface defining a bore, the seal being disposed within the bore and coupled with the ring. A first axial end of the ring is disposed against the bearing outer ring, or a spacer disposed axially between the load ring and the bearing outer ring, and a second axial end is disposed against a radial surface of the outer member. The load ring is configured to support axial loading on, and to prevent axial displacement of, the bearing outer ring.