Abstract: The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain has numerous O-glycosylation sites. Domain 2 is a repeat domain comprising homologous repeat units of 156 amino acids. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. The repeat units are the sites of OC125 and M11 antibody binding. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail.

Abstract: The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is assembled by combining five genomic exons, four very short amino terminal sequences and one extraordinarily large exon. This domain is dominated by its capacity for O-glycosylation and its resultant richness in serine and threonine residues. The molecular structure is dominated by a repeat domain comprising 156 amino acid repeat units, which encompass the epitope binding sites. More than 60 repeat units have been identified, sequenced, and contiguously placed in the CA125 domain structure. The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding.

Abstract: A current sensing system includes a number of remote current sensors for measuring the magnetic field surrounding each conductor of an electrical transmission system to independently monitor the current flowing through the conductors. A generally U-shaped mounting fixture is provided for supporting the current sensors in a fixed, predetermined orientation relative to each of the conductors. An electronic compensation circuit is provided for conditioning the output of each the sensors with the output of the other of the sensors to isolate the influence of the magnetic field induced by the current flowing through only one of the conductors.