Patents by Inventor John B. MACMILLAN

John B. MACMILLAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9757379
    Abstract: Provided is a method of inhibiting heterodimerization of HIF-2? to HIF1? (ARNT) comprising binding certain small molecules to the HIF-2? PAS-B domain cavity but not to HIF1? and inhibiting HIF-2? heterodimerization to HIF1? (ARNT) but not inhibiting HIF1? heterodimerization to HIF1? (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2? heterodimerization inhibitors and also simply as certain small molecules.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: September 12, 2017
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Richard K. Bruick, Charles G. Caldwell, Doug E. Frantz, Kevin H. Gardner, John B. MacMillan, Thomas H. Scheuermann, Uttam K. Tambar
  • Publication number: 20160250216
    Abstract: Provided is a method of inhibiting heterodimerization of HIF-2? to HIF1? (ARNT) comprising binding certain small molecules to the HIF-2? PAS-B domain cavity but not to HIF1? and inhibiting HIF-2? heterodimerization to HIF1? (ARNT) but not inhibiting HIF1? heterodimerization to HIF1? (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2? heterodimerization inhibitors and also simply as certain small molecules.
    Type: Application
    Filed: November 14, 2013
    Publication date: September 1, 2016
    Applicant: tHE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Richard K. BRUICK, Charles G. CALDWELL, Doug E. FRANTZ, Kevin H. GARDNER, John B. MACMILLAN, Thomas H. SCHEUERMANN, Uttam K. TAMBAR