Abstract: An augmented spanning fixation bone plate assembly combines an augmentation fixation bone plate with a spanning fixation bone plate. The augmentation fixation bone plate may be detachably attachable to the spanning fixation bone plate and may be slidably engaged with the spanning fixation bone plate to allow the augmentation fixation bone plate to be positioned for augmented fixation, wherein one or more separate bones are fixed with respect to the spanning fixation bone plate. An augmentation fixation bone plate may have one or more wings that extend laterally from the spanning fixation bone plate. An augmentation fixation bone plate may have two wings that extend in opposing lateral directions from the spanning fixation bone. A wing has a fastener aperture that may be slotted and may have an insert to enable directional fixation, wherein the fastener extends in an offset angle.

Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

Abstract: A weight-based tubular interlock apparatus adapted to determine whether a tubular is engagingly gripped by a rig-based hoisting device or a secondary gripping device is described. The apparatus includes at least two gripping mechanisms and an interlock system operatively connected that is adapted to measure a tubular load on at least one of the gripping mechanisms and to compare the tubular load to a predetermined load to deter nine whether the at least one gripping mechanism is gripping the tubular. The gripping mechanism is adapted to release the tubular only when the tubular load meets the predetermined load, upon which a release force sufficient to release the tubular from the gripping mechanism is applied to the tubular relative to the gripping mechanism. Methods of using the interlock apparatus are also described.

Abstract: An automated tubular handling system adapted to make-up or break-out tubulars that includes a rotary drive adapted to operatively grip a tubular to be connected to or disconnected from a tubular string, a controller adapted to receive and process data indicative of a rotation, torque, and minimum time value associated with a make-up or a break-out of the tubular string, and a user interface adapted to convey the received data, the predetermined values, or both, of the tubular make-up or break-out to an operator. The controller compares the rotation, torque, and minimum time values to acceptable predetermined values to determine when the make-up or the break-out is complete. Automated methods are also disclosed.

Abstract: An automated tubular handling system adapted to make-up or break-out tubulars that includes a rotary drive adapted to operatively grip a tubular to be connected to or disconnected from a tubular string, a controller adapted to receive and process data indicative of a rotation, torque, and minimum time value associated with a make-up or a break-out of the tubular string, and a user interface adapted to convey the received data, the predetermined values, or both, of the tubular make-up or break-out to an operator. The controller compares the rotation, torque, and minimum time values to acceptable predetermined values to determine when the make-up or the break-out is complete. Automated methods are also disclosed.

Abstract: An automated tubular handling system adapted to make-up or break-out tubulars that includes a rotary drive adapted to operatively grip a tubular to be connected to or disconnected from a tubular string, a controller adapted to receive and process data indicative of a rotation, torque, and minimum time value associated with a make-up or a break-out of the tubular string, and a user interface adapted to convey the received data, the predetermined values, or both, of the tubular make-up or break-out to an operator. The controller compares the rotation, torque, and minimum time values to acceptable predetermined values to determine when the make-up or the break-out is complete. Automated methods are also disclosed.

Abstract: A weight-based tubular interlock apparatus adapted to determine whether a tubular is engagingly gripped by a rig-based hoisting device or a secondary gripping device is described. The apparatus includes at least two gripping mechanisms and an interlock system operatively connected that is adapted to measure a tubular load on at least one of the gripping mechanisms and to compare the tubular load to a predetermined load to deter nine whether the at least one gripping mechanism is gripping the tubular. The gripping mechanism is adapted to release the tubular only when the tubular load meets the predetermined load, upon which a release force sufficient to release the tubular from the gripping mechanism is applied to the tubular relative to the gripping mechanism. Methods of using the interlock apparatus are also described.

Abstract: An automated tubular handling system adapted to make-up or break-out tubulars that includes a rotary drive adapted to operatively grip a tubular to be connected to or disconnected from a tubular string, a controller adapted to receive and process data indicative of a rotation, torque, and minimum time value associated with a make-up or a break-out of the tubular string, and a user interface adapted to convey the received data, the predetermined values, or both, of the tubular make-up or break-out to an operator. The controller compares the rotation, torque, and minimum time values to acceptable predetermined values to determine when the make-up or the break-out is complete. Automated methods are also disclosed.

Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.