Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: An apparatus and a method are described for forming a chemical modulation of a substance present in a fluid stream, which utilize a movable device, such as a movable heater, to induce changes in the retention of a chemical substance flowing through the modulator tube. The modulator tube has an inlet, a first portion in communication with the inlet, a second portion in communication with said first portion, and an outlet in communication with said second portion. The method involves causing a chemical modulation by moving retention alteration device relative to a modulator tube.

Abstract: A practical device and method of performing comprehensive multi-dimensional chemical separation using a first dimension of a two-dimensional chromatograph to generate a chromatogram in a time comparable to or even faster than common practice while the second dimension generates multiple chromatograms each in a time comparable to the fastest prior art chromatography. The transfer of sample portions from the first dimension to the second dimension is by any one of several sample stream modulation techniques. These techniques accumulate portions of sample between the first and the second dimensions transferring them as very sharp concentration pulses analogous to fast injections, without loss of sample and with a substantial improvement in sensitivity.

Abstract: To provide a compact, sensitive comprehensive, two-dimensional gas chromatograph, a chromatographic column has first and second sections in series with each other to permit the flow of sample and a carrier through the first section and the second section. The retention time of the second section is less than the band resolution time of the first section. To control the wave fronts between the first and second sections, first and second heaters are positioned to heat and drive off sample collected at the outlet of the first section for collection in the second section and to heat sample collected at the inlet of the second section so that the first heater rapidly drives off sample for collection in the second section and then the second section rapidly drives off sample in a sharp wave front while the first section is accumulating another band for later movement into the second section.