Abstract: An analyte detection device includes a fluid impermeable layer having a first thickness and at least one inlet port having a diameter, the at least one inlet port defining a fluid pathway through the first thickness. The device also includes a reagent-hosting layer having a second thickness and including at least one of a chemical reagent and a bio-chemical reagent. The reagent-hosting layer is configured to radially receive a sampling fluid via the fluid pathway, where the sampling fluid is configured to interact with the at least one of a chemical reagent and a bio-chemical reagent in the reagent-hosting layer to indicate a characteristic associated with an analyte in the sampling fluid.