Patent number: 6448255
Abstract: Antiatherosclerotic compounds are provided which have the following structure:
wherein:
R is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, heteroaryl, or aryl or heteroaryl substituted with one or more members of the group consisting of alkyl, hydroxy, alkoxy, perfluoroalkyl, perfluoroalkoxy, alkylthio, nitro, amino, mono or di-alkylamino, and halogen;
D is C—H, carbon bound to R5 or nitrogen;
R1, R2, R3, and R4 are each independently hydrogen, alkyl, or taken together form a ring;
R5 is one or more groups selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, hydroxy, alkoxy, perfluoroalkyl, perfluoroalkoxy, alkylthio, nitro, amino, mono or di-alkylamino, or halogen;
n is an integer of 0-3;
or pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
September 28, 2001
Date of Patent:
September 10, 2002
Assignee:
Wyeth
Inventors:
Hassan M. Elokdah, Theodore S. Sulkowski, Sie-Yearl Chai, John Babiak
