Abstract: A method for coating a material on targeted surfaces, such as on an implantable medical device, includes providing a spray application apparatus that defines an application zone within which a spray device is disposed, and supplying the spray device with a material solution including an activatable species. The object having the surfaces targeted for coating is placed within the application zone and subjected to the concurrent application of the material solution and a stimulus, with the stimulus operably activating the activatable species.

Abstract: A multiple layer coating for application upon surfaces of an implantable medical device, a first layer of such coating includes an anti-thrombogenic factor and a second layer of such coating includes a hyperplasia inhibiting factor that is releasably contained therein. The hyperplasia inhibiting factor is controllably released from the multiple layer coating over a predetermined period of time upon implantation of the medical device in vivo.